PBRM1 bromodomains associate with RNA to facilitate chromatin association

Abstract PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40–50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin binding subunit of the PBAF complex, but the molecular mechanism underlying this activity is not fully known....

Full description

Bibliographic Details

Published in:	Nucleic acids research Vol. 51; no. 8; pp. 3631 - 3649
Main Authors:	De Silva, Saumya M, Dhiman, Alisha, Sood, Surbhi, Mercedes, Kilsia F, Simmons, William J, Henen, Morkos A, Vögeli, Beat, Dykhuizen, Emily C, Musselman, Catherine A
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 08.05.2023
Subjects:	Chromatin - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene regulation, Chromatin and Epigenetics Histones - metabolism Humans Kidney Neoplasms - genetics Nuclear Proteins - metabolism RNA - genetics Transcription Factors - metabolism
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!