PBRM1 bromodomains associate with RNA to facilitate chromatin association

Abstract PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40–50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin binding subunit of the PBAF complex, but the molecular mechanism underlying this activity is not fully known....

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Vydáno v:	Nucleic acids research Ročník 51; číslo 8; s. 3631 - 3649
Hlavní autoři:	De Silva, Saumya M, Dhiman, Alisha, Sood, Surbhi, Mercedes, Kilsia F, Simmons, William J, Henen, Morkos A, Vögeli, Beat, Dykhuizen, Emily C, Musselman, Catherine A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 08.05.2023
Témata:	Chromatin - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene regulation, Chromatin and Epigenetics Histones - metabolism Humans Kidney Neoplasms - genetics Nuclear Proteins - metabolism RNA - genetics Transcription Factors - metabolism
ISSN:	0305-1048, 1362-4962, 1362-4962
On-line přístup:	Získat plný text
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