A maleness gene in the malaria mosquito Anopheles gambiae

The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome-linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 353; číslo 6294; s. 67 - 69
Hlavní autoři: Krzywinska, Elzbieta, Dennison, Nathan J, Lycett, Gareth J, Krzywinski, Jaroslaw
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.07.2016
Témata:
Alternative Splicing
Animals
Animals, Genetically Modified - genetics
Anopheles - embryology
Anopheles - genetics
Gene Silencing
Genes, Lethal
Insect Proteins - genetics
Insect Vectors - genetics
Malaria - parasitology
Male
Sex Determination Processes - genetics
Transcription, Genetic
Y Chromosome - genetics
ISSN:1095-9203
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
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Abstract The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome-linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's life, controls male-specific splicing of the doublesex gene. Silencing embryonic Yob expression is male-lethal, whereas ectopic embryonic delivery of Yob transcripts yields male-only broods. This female-killing property may be an invaluable tool for creation of conditional male-only transgenic Anopheles strains for malaria control programs.
AbstractList The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome-linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's life, controls male-specific splicing of the doublesex gene. Silencing embryonic Yob expression is male-lethal, whereas ectopic embryonic delivery of Yob transcripts yields male-only broods. This female-killing property may be an invaluable tool for creation of conditional male-only transgenic Anopheles strains for malaria control programs.
Author Lycett, Gareth J
Dennison, Nathan J
Krzywinska, Elzbieta
Krzywinski, Jaroslaw
Author_xml – sequence: 1
  givenname: Elzbieta
  surname: Krzywinska
  fullname: Krzywinska, Elzbieta
  organization: The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK
– sequence: 2
  givenname: Nathan J
  surname: Dennison
  fullname: Dennison, Nathan J
  organization: Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. Department of Life Sciences, Imperial College, South Kensington Campus, London SW7 2AZ, UK
– sequence: 3
  givenname: Gareth J
  surname: Lycett
  fullname: Lycett, Gareth J
  organization: Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
– sequence: 4
  givenname: Jaroslaw
  surname: Krzywinski
  fullname: Krzywinski, Jaroslaw
  email: jaroslaw.krzywinski@pirbright.ac.uk
  organization: The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK. Vector Biology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. jaroslaw.krzywinski@pirbright.ac.uk
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27365445$$D View this record in MEDLINE/PubMed
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Snippet The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is...
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SubjectTerms Alternative Splicing
Animals
Animals, Genetically Modified - genetics
Anopheles - embryology
Anopheles - genetics
Gene Silencing
Genes, Lethal
Insect Proteins - genetics
Insect Vectors - genetics
Malaria - parasitology
Male
Sex Determination Processes - genetics
Transcription, Genetic
Y Chromosome - genetics
Title A maleness gene in the malaria mosquito Anopheles gambiae
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