Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

DNA viruses typically eject genomic DNA into the nuclei of host cells after entry. It is unclear, however, how nuclear pathogen-derived DNA triggers innate immune responses. We report that heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) recognizes pathogenic DNA and amplifies interferon-α/β...

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Vydané v:	Science (American Association for the Advancement of Science) Ročník 365; číslo 6454
Hlavní autori:	Wang, Lei, Wen, Mingyue, Cao, Xuetao
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 16.08.2019
Predmet:	Adenosine - analogs & derivatives Adenosine - metabolism Animals Cell Nucleus - immunology Cell Nucleus - virology Cytoplasm - metabolism DNA Virus Infections - immunology DNA, Viral - immunology HEK293 Cells Herpesvirus 1, Human - immunology Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism Humans Immunity, Innate Interferon Regulatory Factor-3 Interferon-alpha - metabolism Interferon-beta - metabolism Jumonji Domain-Containing Histone Demethylases - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Nuclear Proteins - metabolism Nucleotidyltransferases - metabolism Phosphoproteins - metabolism Protein Transport Protein-Serine-Threonine Kinases - metabolism RAW 264.7 Cells
ISSN:	1095-9203, 1095-9203
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