Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate the translocation of phospholipids from the outer to the inner leaflet and maintain lipid asymmetry, which is critical for membrane trafficking and signaling pathways. Here, we report the cryo-electron microscopy...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Science (American Association for the Advancement of Science) Ročník 365; číslo 6458; s. 1149
Hlavní autori:	Hiraizumi, Masahiro, Yamashita, Keitaro, Nishizawa, Tomohiro, Nureki, Osamu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 13.09.2019
Predmet:	Adenosine Triphosphatases - chemistry Adenosine Triphosphate - chemistry Amino Acid Sequence Binding Sites Cryoelectron Microscopy HEK293 Cells Humans Membrane Proteins - chemistry Models, Molecular Phosphatidylserines Phospholipid Transfer Proteins - chemistry Phospholipids - metabolism Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein Structure, Quaternary Sequence Alignment
ISSN:	1095-9203, 1095-9203
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!