Large-scale integration of the plasma proteome with genetics and disease

The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (p...

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Vydané v:	Nature genetics Ročník 53; číslo 12; s. 1712 - 1721
Hlavní autori:	Ferkingstad, Egil, Sulem, Patrick, Atlason, Bjarni A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Styrmisdottir, Edda L., Gunnarsdottir, Kristbjorg, Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Bjarni V., Jensson, Brynjar O., Zink, Florian, Halldorsson, Gisli H., Masson, Gisli, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Juliusson, Kristinn, Magnusson, Magnus K., Magnusson, Olafur Th, Fridriksdottir, Run, Saevarsdottir, Saedis, Gudjonsson, Sigurjon A., Stacey, Simon N., Rognvaldsson, Solvi, Eiriksdottir, Thjodbjorg, Olafsdottir, Thorunn A., Steinthorsdottir, Valgerdur, Tragante, Vinicius, Ulfarsson, Magnus O., Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Lund, Sigrun H., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Stefansson, Kari
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.12.2021 Nature Publishing Group
Predmet:	45/23 45/43 45/91 631/114/2784 631/208/205/2138 692/308/2056 82/47 82/79 82/80 Agriculture Animal Genetics and Genomics Aptamers Biomarkers Biomarkers - blood Biomedical and Life Sciences Biomedicine Blood Proteins - genetics Blood Proteins - metabolism Cancer Research Disease Disease - genetics Female Gene expression Gene Frequency Gene Function Genetic Variation Genetics Genome-Wide Association Study Genomes Genomics Human Genetics Humans Male Middle Aged Pathogenesis Plasma Plasma proteins Proteins Proteome - genetics Proteomes Quantitative Trait Loci
ISSN:	1061-4036, 1546-1718, 1546-1718
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