Large-scale integration of the plasma proteome with genetics and disease
The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (p...
Uložené v:
| Vydané v: | Nature genetics Ročník 53; číslo 12; s. 1712 - 1721 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
New York
Nature Publishing Group US
01.12.2021
Nature Publishing Group |
| Predmet: | |
| ISSN: | 1061-4036, 1546-1718, 1546-1718 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (protein quantitative trait loci; pQTL), of which 19% were with rare variants (minor allele frequency (MAF) < 1%). We tested plasma protein levels for association with 373 diseases and other traits and identified 257,490 associations. We integrated pQTL and genetic associations with diseases and other traits and found that 12% of 45,334 lead associations in the GWAS Catalog are with variants in high linkage disequilibrium with pQTL. We identified 938 genes encoding potential drug targets with variants that influence levels of possible biomarkers. Combining proteomics, genomics and transcriptomics, we provide a valuable resource that can be used to improve understanding of disease pathogenesis and to assist with drug discovery and development.
A genome-wide association study of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders highlights links with over 370 disease endpoints and other traits. |
|---|---|
| AbstractList | The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (protein quantitative trait loci; pQTL), of which 19% were with rare variants (minor allele frequency (MAF) < 1%). We tested plasma protein levels for association with 373 diseases and other traits and identified 257,490 associations. We integrated pQTL and genetic associations with diseases and other traits and found that 12% of 45,334 lead associations in the GWAS Catalog are with variants in high linkage disequilibrium with pQTL. We identified 938 genes encoding potential drug targets with variants that influence levels of possible biomarkers. Combining proteomics, genomics and transcriptomics, we provide a valuable resource that can be used to improve understanding of disease pathogenesis and to assist with drug discovery and development.
A genome-wide association study of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders highlights links with over 370 disease endpoints and other traits. The proteome also introduces a new temporal quality: the levels of proteins may rise or fall as a function of time before or after an event or as disease progresses or regresses. [...]far, the largest pQTL study (n = 30,931) only assessed 90 proteins8, whereas the largest study with 200 or more proteins had less than 6,000 participants5. Here we report the analysis of the associations of 27.2 million sequence variants and 373 diseases and other traits with the levels of 4,907 plasma proteins measured in 35,559 Icelanders with SomaScan version 4 (Figs. 1 and 2). Accounting for multiple testing, the levels of 63% of the 4,907 proteins correlated positively with age and 18% correlated negatively with age (Supplementary Table 1). [...]levels of 33% of the proteins were higher in men and 23% were higher in women. Overall, the presence of PAVs in high LD, the absence of cis eQTL and lower protein levels associated with the alternative allele all increase the likelihood of an aptamer binding artifact (Fig. 4a,b and Extended Data Fig. 4). The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (protein quantitative trait loci; pQTL), of which 19% were with rare variants (minor allele frequency (MAF) < 1%). We tested plasma protein levels for association with 373 diseases and other traits and identified 257,490 associations. We integrated pQTL and genetic associations with diseases and other traits and found that 12% of 45,334 lead associations in the GWAS Catalog are with variants in high linkage disequilibrium with pQTL. We identified 938 genes encoding potential drug targets with variants that influence levels of possible biomarkers. Combining proteomics, genomics and transcriptomics, we provide a valuable resource that can be used to improve understanding of disease pathogenesis and to assist with drug discovery and development. The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (protein quantitative trait loci; pQTL), of which 19% were with rare variants (minor allele frequency (MAF) < 1%). We tested plasma protein levels for association with 373 diseases and other traits and identified 257,490 associations. We integrated pQTL and genetic associations with diseases and other traits and found that 12% of 45,334 lead associations in the GWAS Catalog are with variants in high linkage disequilibrium with pQTL. We identified 938 genes encoding potential drug targets with variants that influence levels of possible biomarkers. Combining proteomics, genomics and transcriptomics, we provide a valuable resource that can be used to improve understanding of disease pathogenesis and to assist with drug discovery and development.The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma (protein quantitative trait loci; pQTL), of which 19% were with rare variants (minor allele frequency (MAF) < 1%). We tested plasma protein levels for association with 373 diseases and other traits and identified 257,490 associations. We integrated pQTL and genetic associations with diseases and other traits and found that 12% of 45,334 lead associations in the GWAS Catalog are with variants in high linkage disequilibrium with pQTL. We identified 938 genes encoding potential drug targets with variants that influence levels of possible biomarkers. Combining proteomics, genomics and transcriptomics, we provide a valuable resource that can be used to improve understanding of disease pathogenesis and to assist with drug discovery and development. |
| Author | Oddsson, Asmundur Masson, Gisli Fridriksdottir, Run Norddahl, Gudmundur L. Rognvaldsson, Solvi Melsted, Pall Halldorsson, Bjarni V. Olafsdottir, Thorunn A. Atlason, Bjarni A. Sveinbjornsson, Gardar Gunnarsdottir, Kristbjorg Thorsteinsdottir, Unnur Saevarsdottir, Saedis Halldorsson, Gisli H. Steinthorsdottir, Valgerdur Rafnar, Thorunn Eiriksdottir, Thjodbjorg Holm, Hilma Lund, Sigrun H. Ferkingstad, Egil Styrmisdottir, Edda L. Gudbjartsson, Daniel F. Tragante, Vinicius Jensson, Brynjar O. Helgason, Agnar Stefansson, Kari Sulem, Patrick Jonsdottir, Ingileif Arnadottir, Gudny A. Katrinardottir, Hildigunnur Saemundsdottir, Jona Magnusson, Magnus I. Zink, Florian Magnusson, Magnus K. Gudjonsson, Sigurjon A. Stacey, Simon N. Ulfarsson, Magnus O. Juliusson, Kristinn Stefansson, Hreinn Magnusson, Olafur Th |
| Author_xml | – sequence: 1 givenname: Egil orcidid: 0000-0001-8090-7988 surname: Ferkingstad fullname: Ferkingstad, Egil organization: deCODE genetics/Amgen, Inc – sequence: 2 givenname: Patrick orcidid: 0000-0001-7123-6123 surname: Sulem fullname: Sulem, Patrick email: patrick.sulem@decode.is organization: deCODE genetics/Amgen, Inc – sequence: 3 givenname: Bjarni A. surname: Atlason fullname: Atlason, Bjarni A. organization: deCODE genetics/Amgen, Inc – sequence: 4 givenname: Gardar surname: Sveinbjornsson fullname: Sveinbjornsson, Gardar organization: deCODE genetics/Amgen, Inc – sequence: 5 givenname: Magnus I. surname: Magnusson fullname: Magnusson, Magnus I. organization: deCODE genetics/Amgen, Inc – sequence: 6 givenname: Edda L. surname: Styrmisdottir fullname: Styrmisdottir, Edda L. organization: deCODE genetics/Amgen, Inc – sequence: 7 givenname: Kristbjorg surname: Gunnarsdottir fullname: Gunnarsdottir, Kristbjorg organization: deCODE genetics/Amgen, Inc – sequence: 8 givenname: Agnar orcidid: 0000-0002-8545-3767 surname: Helgason fullname: Helgason, Agnar organization: deCODE genetics/Amgen, Inc., Department of Anthropology, University of Iceland – sequence: 9 givenname: Asmundur orcidid: 0000-0002-4606-5163 surname: Oddsson fullname: Oddsson, Asmundur organization: deCODE genetics/Amgen, Inc – sequence: 10 givenname: Bjarni V. orcidid: 0000-0003-0756-0767 surname: Halldorsson fullname: Halldorsson, Bjarni V. organization: deCODE genetics/Amgen, Inc., School of Science and Engineering, Reykjavik University – sequence: 11 givenname: Brynjar O. surname: Jensson fullname: Jensson, Brynjar O. organization: deCODE genetics/Amgen, Inc – sequence: 12 givenname: Florian surname: Zink fullname: Zink, Florian organization: deCODE genetics/Amgen, Inc – sequence: 13 givenname: Gisli H. orcidid: 0000-0001-7067-9862 surname: Halldorsson fullname: Halldorsson, Gisli H. organization: deCODE genetics/Amgen, Inc – sequence: 14 givenname: Gisli surname: Masson fullname: Masson, Gisli organization: deCODE genetics/Amgen, Inc – sequence: 15 givenname: Gudny A. orcidid: 0000-0001-6571-423X surname: Arnadottir fullname: Arnadottir, Gudny A. organization: deCODE genetics/Amgen, Inc – sequence: 16 givenname: Hildigunnur surname: Katrinardottir fullname: Katrinardottir, Hildigunnur organization: deCODE genetics/Amgen, Inc – sequence: 17 givenname: Kristinn surname: Juliusson fullname: Juliusson, Kristinn organization: deCODE genetics/Amgen, Inc – sequence: 18 givenname: Magnus K. orcidid: 0000-0001-8593-4934 surname: Magnusson fullname: Magnusson, Magnus K. organization: deCODE genetics/Amgen, Inc., Faculty of Medicine, School of Health Sciences, University of Iceland – sequence: 19 givenname: Olafur Th surname: Magnusson fullname: Magnusson, Olafur Th organization: deCODE genetics/Amgen, Inc – sequence: 20 givenname: Run surname: Fridriksdottir fullname: Fridriksdottir, Run organization: deCODE genetics/Amgen, Inc – sequence: 21 givenname: Saedis orcidid: 0000-0001-9392-6184 surname: Saevarsdottir fullname: Saevarsdottir, Saedis organization: deCODE genetics/Amgen, Inc., Faculty of Medicine, School of Health Sciences, University of Iceland – sequence: 22 givenname: Sigurjon A. surname: Gudjonsson fullname: Gudjonsson, Sigurjon A. organization: deCODE genetics/Amgen, Inc – sequence: 23 givenname: Simon N. orcidid: 0000-0002-4732-7380 surname: Stacey fullname: Stacey, Simon N. organization: deCODE genetics/Amgen, Inc – sequence: 24 givenname: Solvi orcidid: 0000-0002-4376-3361 surname: Rognvaldsson fullname: Rognvaldsson, Solvi organization: deCODE genetics/Amgen, Inc – sequence: 25 givenname: Thjodbjorg orcidid: 0000-0003-1009-7398 surname: Eiriksdottir fullname: Eiriksdottir, Thjodbjorg organization: deCODE genetics/Amgen, Inc – sequence: 26 givenname: Thorunn A. surname: Olafsdottir fullname: Olafsdottir, Thorunn A. organization: deCODE genetics/Amgen, Inc., Faculty of Medicine, School of Health Sciences, University of Iceland – sequence: 27 givenname: Valgerdur orcidid: 0000-0003-1846-6274 surname: Steinthorsdottir fullname: Steinthorsdottir, Valgerdur organization: deCODE genetics/Amgen, Inc – sequence: 28 givenname: Vinicius orcidid: 0000-0002-8223-8957 surname: Tragante fullname: Tragante, Vinicius organization: deCODE genetics/Amgen, Inc – sequence: 29 givenname: Magnus O. orcidid: 0000-0002-0461-040X surname: Ulfarsson fullname: Ulfarsson, Magnus O. organization: deCODE genetics/Amgen, Inc., Faculty of Electrical and Computer Engineering, University of Iceland – sequence: 30 givenname: Hreinn orcidid: 0000-0002-9331-6666 surname: Stefansson fullname: Stefansson, Hreinn organization: deCODE genetics/Amgen, Inc – sequence: 31 givenname: Ingileif orcidid: 0000-0001-8339-150X surname: Jonsdottir fullname: Jonsdottir, Ingileif organization: deCODE genetics/Amgen, Inc., Faculty of Medicine, School of Health Sciences, University of Iceland – sequence: 32 givenname: Hilma orcidid: 0000-0002-9517-6636 surname: Holm fullname: Holm, Hilma organization: deCODE genetics/Amgen, Inc – sequence: 33 givenname: Thorunn orcidid: 0000-0003-0491-7046 surname: Rafnar fullname: Rafnar, Thorunn organization: deCODE genetics/Amgen, Inc – sequence: 34 givenname: Pall surname: Melsted fullname: Melsted, Pall organization: deCODE genetics/Amgen, Inc., School of Engineering and Natural Sciences, University of Iceland – sequence: 35 givenname: Jona surname: Saemundsdottir fullname: Saemundsdottir, Jona organization: deCODE genetics/Amgen, Inc – sequence: 36 givenname: Gudmundur L. surname: Norddahl fullname: Norddahl, Gudmundur L. organization: deCODE genetics/Amgen, Inc – sequence: 37 givenname: Sigrun H. orcidid: 0000-0002-3806-2296 surname: Lund fullname: Lund, Sigrun H. organization: deCODE genetics/Amgen, Inc – sequence: 38 givenname: Daniel F. orcidid: 0000-0002-5222-9857 surname: Gudbjartsson fullname: Gudbjartsson, Daniel F. organization: deCODE genetics/Amgen, Inc., School of Engineering and Natural Sciences, University of Iceland – sequence: 39 givenname: Unnur surname: Thorsteinsdottir fullname: Thorsteinsdottir, Unnur organization: deCODE genetics/Amgen, Inc., Faculty of Medicine, School of Health Sciences, University of Iceland – sequence: 40 givenname: Kari orcidid: 0000-0003-1676-864X surname: Stefansson fullname: Stefansson, Kari email: kstefans@decode.is organization: deCODE genetics/Amgen, Inc., Faculty of Medicine, School of Health Sciences, University of Iceland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34857953$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU1LJDEQhsPisurs_gEPEvDiJW6-O30U8QsGvOyeQ7pTPUa602OSYfDfGx0HwYOnqsPzFC_1HqODOEdA6ITRC0aF-ZslU8YQyhmhtG0M2f5AR0xJTVjDzEHdqWZEUqEP0XHOT5QyKan5hQ6FNKpplThCd0uXVkBy70bAIRZYJVfCHPE84PIIeD26PDm8TnOBeQK8DeURryBCCX3GLnrsQwaX4Tf6Obgxw5-PuUD_b67_Xd2R5cPt_dXlkvSSiUKk82JQrZdGgubGg_cGfMsHLXuuO688lx1rfCc6pZ3TqnU18zAMnGnaSCcW6Hx3t0Z63kAudgq5h3F0EeZNtlxT3XLBmajo2Rf0ad6kWNO9UUbRpmlMpU4_qE03gbfrFCaXXuz-RxUwO6BPc84JBtuH8v6kklwYLaP2rQ67q8PWOux7HXZbVf5F3V__VhI7KVc4riB9xv7GegXSNpy8 |
| CitedBy_id | crossref_primary_10_3390_ijms242115879 crossref_primary_10_7554_eLife_88863_3 crossref_primary_10_1136_annrheumdis_2021_221754 crossref_primary_10_1002_art_43125 crossref_primary_10_1038_s41435_025_00352_4 crossref_primary_10_1016_j_intimp_2024_112520 crossref_primary_10_1016_j_jaci_2024_10_002 crossref_primary_10_1016_j_talanta_2024_126990 crossref_primary_10_3389_fendo_2023_1339374 crossref_primary_10_3389_fendo_2024_1448314 crossref_primary_10_1007_s12672_025_02550_y crossref_primary_10_1007_s00011_024_01955_9 crossref_primary_10_1007_s00535_025_02252_w crossref_primary_10_1038_s41598_025_01216_7 crossref_primary_10_1097_JS9_0000000000001990 crossref_primary_10_1016_j_jad_2025_04_124 crossref_primary_10_1038_s41588_024_02052_7 crossref_primary_10_1016_j_pnpbp_2025_111477 crossref_primary_10_1093_hmg_ddae159 crossref_primary_10_1186_s13024_023_00684_7 crossref_primary_10_3389_fendo_2025_1642197 crossref_primary_10_1111_ene_15820 crossref_primary_10_1016_j_atherosclerosis_2025_120414 crossref_primary_10_1111_aji_70063 crossref_primary_10_1038_s41591_024_03355_2 crossref_primary_10_1007_s10067_025_07508_7 crossref_primary_10_1161_JAHA_124_037802 crossref_primary_10_1016_j_jlr_2025_100871 crossref_primary_10_1056_NEJMoa2300792 crossref_primary_10_1186_s12967_025_06099_w crossref_primary_10_1016_j_heliyon_2024_e38815 crossref_primary_10_1038_s41588_022_01051_w crossref_primary_10_1007_s10067_025_07606_6 crossref_primary_10_1002_ana_26743 crossref_primary_10_1016_j_jpba_2025_117038 crossref_primary_10_1038_s43586_022_00188_6 crossref_primary_10_1016_j_jid_2024_07_021 crossref_primary_10_1161_JAHA_124_039195 crossref_primary_10_1016_j_ab_2025_115946 crossref_primary_10_1161_STROKEAHA_124_049808 crossref_primary_10_1126_science_abn0910 crossref_primary_10_1053_j_gastro_2023_01_028 crossref_primary_10_1161_ATVBAHA_124_320674 crossref_primary_10_1016_j_jad_2024_10_126 crossref_primary_10_1080_0886022X_2024_2436632 crossref_primary_10_2217_epi_2022_0119 crossref_primary_10_1186_s10194_024_01922_z crossref_primary_10_1186_s12916_024_03700_9 crossref_primary_10_1038_s41467_025_56935_2 crossref_primary_10_1016_j_csbj_2024_05_012 crossref_primary_10_1080_14789450_2022_2070477 crossref_primary_10_3389_fendo_2024_1449668 crossref_primary_10_1016_j_pan_2025_08_014 crossref_primary_10_1007_s12672_025_02956_8 crossref_primary_10_1161_ATVBAHA_122_317984 crossref_primary_10_3389_fphar_2025_1496061 crossref_primary_10_3389_fgene_2025_1609933 crossref_primary_10_3389_fimmu_2024_1379480 crossref_primary_10_1136_bmjdrc_2023_003966 crossref_primary_10_1186_s12967_023_04525_5 crossref_primary_10_1186_s41927_025_00521_y crossref_primary_10_1007_s10067_025_07596_5 crossref_primary_10_1007_s12672_025_02476_5 crossref_primary_10_3390_cancers14092227 crossref_primary_10_1038_s41591_025_03831_3 crossref_primary_10_1097_MD_0000000000042050 crossref_primary_10_3390_ijms252212106 crossref_primary_10_1007_s12672_025_03318_0 crossref_primary_10_1038_s41598_024_72970_3 crossref_primary_10_1097_MD_0000000000042290 crossref_primary_10_1007_s00439_023_02562_0 crossref_primary_10_1038_s41467_024_45233_y crossref_primary_10_1186_s12967_024_04928_y crossref_primary_10_7554_eLife_88863 crossref_primary_10_1016_j_jid_2025_08_014 crossref_primary_10_1038_s41467_023_41642_7 crossref_primary_10_1097_MD_0000000000044105 crossref_primary_10_3390_biomedicines13081841 crossref_primary_10_1007_s12672_025_02968_4 crossref_primary_10_3390_biomedicines13020306 crossref_primary_10_1016_j_mayocp_2024_12_016 crossref_primary_10_3390_biom14030355 crossref_primary_10_1016_j_jaad_2024_11_050 crossref_primary_10_2337_db25_0067 crossref_primary_10_1097_JS9_0000000000002634 crossref_primary_10_3389_fimmu_2024_1428962 crossref_primary_10_3390_ijms241914982 crossref_primary_10_2147_IJWH_S491414 crossref_primary_10_3389_fimmu_2024_1347112 crossref_primary_10_1007_s00335_025_10154_8 crossref_primary_10_1038_s41598_024_73466_w crossref_primary_10_1038_s10038_022_01111_3 crossref_primary_10_1186_s12933_024_02431_8 crossref_primary_10_1007_s00125_024_06097_5 crossref_primary_10_1111_ane_13700 crossref_primary_10_1186_s13073_025_01463_3 crossref_primary_10_1177_13872877251333811 crossref_primary_10_1007_s10654_023_01038_9 crossref_primary_10_1007_s10557_023_07467_8 crossref_primary_10_1093_hmg_ddae110 crossref_primary_10_1007_s40520_025_03043_2 crossref_primary_10_1097_MD_0000000000044693 crossref_primary_10_1007_s12035_024_04542_5 crossref_primary_10_1016_j_fertnstert_2024_02_011 crossref_primary_10_1016_j_intimp_2024_113520 crossref_primary_10_1016_j_jtha_2023_06_040 crossref_primary_10_1016_j_tig_2023_05_002 crossref_primary_10_1093_cvr_cvaf078 crossref_primary_10_3390_biomedicines13071717 crossref_primary_10_1038_s42003_023_05737_7 crossref_primary_10_1016_j_jri_2025_104537 crossref_primary_10_1038_s41467_025_58129_2 crossref_primary_10_3389_fmed_2025_1529495 crossref_primary_10_1016_j_wneu_2025_123794 crossref_primary_10_1038_s41588_023_01609_2 crossref_primary_10_1016_j_jad_2025_119804 crossref_primary_10_1093_schbul_sbaf145 crossref_primary_10_1186_s13073_023_01229_9 crossref_primary_10_1007_s12672_025_03043_8 crossref_primary_10_1093_rheumatology_keaf055 crossref_primary_10_1161_JAHA_123_033190 crossref_primary_10_3389_fphar_2023_1266782 crossref_primary_10_1038_s41467_022_28167_1 crossref_primary_10_1136_thorax_2024_221398 crossref_primary_10_1038_s43856_025_01012_4 crossref_primary_10_1016_j_numecd_2025_104289 crossref_primary_10_1038_s41588_024_01720_y crossref_primary_10_1038_s41588_024_01972_8 crossref_primary_10_1038_s42003_022_03462_1 crossref_primary_10_1186_s13062_025_00631_0 crossref_primary_10_1097_MD_0000000000044660 crossref_primary_10_1186_s12985_025_02754_2 crossref_primary_10_3390_ijms26189099 crossref_primary_10_1093_eurheartj_ehad016 crossref_primary_10_1016_j_atherosclerosis_2025_119110 crossref_primary_10_1038_s41467_023_36392_5 crossref_primary_10_1182_blood_2024027006 crossref_primary_10_1038_s42255_023_00742_w crossref_primary_10_1097_MD_0000000000043447 crossref_primary_10_1016_j_exger_2025_112797 crossref_primary_10_1038_s44325_024_00018_6 crossref_primary_10_1002_wjo2_70038 crossref_primary_10_1038_s41586_023_06547_x crossref_primary_10_1038_s41598_023_27679_0 crossref_primary_10_1167_iovs_66_3_19 crossref_primary_10_1371_journal_pone_0316481 crossref_primary_10_1016_j_jtha_2023_05_012 crossref_primary_10_1186_s12916_025_04127_6 crossref_primary_10_1038_s41401_025_01561_3 crossref_primary_10_1186_s12967_025_06425_2 crossref_primary_10_2147_JPR_S512034 crossref_primary_10_1038_s41598_023_47030_x crossref_primary_10_1007_s12672_024_01460_9 crossref_primary_10_1016_j_isci_2024_110104 crossref_primary_10_1186_s13024_023_00687_4 crossref_primary_10_1371_journal_pmed_1004174 crossref_primary_10_1016_j_ijbiomac_2025_144380 crossref_primary_10_1186_s12859_022_04706_x crossref_primary_10_1016_j_atherosclerosis_2022_09_007 crossref_primary_10_3389_fgene_2024_1440062 crossref_primary_10_1093_ecco_jcc_jjac191 crossref_primary_10_1186_s13024_025_00874_5 crossref_primary_10_1093_jnci_djad247 crossref_primary_10_3389_fimmu_2023_1069379 crossref_primary_10_1093_eurheartj_ehac036 crossref_primary_10_3390_cancers15112930 crossref_primary_10_1080_00365521_2025_2472198 crossref_primary_10_1038_s42255_023_00753_7 crossref_primary_10_1186_s41065_025_00376_w crossref_primary_10_1097_MD_0000000000042485 crossref_primary_10_3389_fendo_2024_1401531 crossref_primary_10_1016_j_jtha_2023_11_013 crossref_primary_10_1038_s41467_024_51744_5 crossref_primary_10_1038_s41467_023_36491_3 crossref_primary_10_1038_s41467_024_46973_7 crossref_primary_10_1038_s41588_024_01851_2 crossref_primary_10_1111_dom_16087 crossref_primary_10_1021_acs_jproteome_5c00221 crossref_primary_10_1038_s41467_025_62463_w crossref_primary_10_1186_s12920_024_01826_6 crossref_primary_10_1002_brb3_70425 crossref_primary_10_1038_s41588_024_01896_3 crossref_primary_10_1093_bjd_ljaf280 crossref_primary_10_3389_fendo_2025_1578944 crossref_primary_10_1161_JAHA_123_033544 crossref_primary_10_1167_tvst_14_5_8 crossref_primary_10_1038_s41467_023_38951_2 crossref_primary_10_1097_SHK_0000000000002465 crossref_primary_10_3389_fimmu_2024_1434369 crossref_primary_10_1161_JAHA_123_033660 crossref_primary_10_1186_s12883_025_04091_x crossref_primary_10_3390_biomedicines13051115 crossref_primary_10_1038_s41467_025_57753_2 crossref_primary_10_1038_s41588_025_02096_3 crossref_primary_10_2147_PTT_S492205 crossref_primary_10_1038_s41562_024_01924_6 crossref_primary_10_1038_s41588_023_01555_z crossref_primary_10_1038_s41398_025_03299_2 crossref_primary_10_2147_JPR_S424086 crossref_primary_10_1007_s00210_025_04429_9 crossref_primary_10_1038_s43587_024_00639_7 crossref_primary_10_1016_j_neuroscience_2025_02_038 crossref_primary_10_1111_cns_14817 crossref_primary_10_1016_j_bbadis_2025_167680 crossref_primary_10_1038_s41590_023_01609_8 crossref_primary_10_1038_s41598_025_86134_4 crossref_primary_10_1167_iovs_66_2_55 crossref_primary_10_1016_j_jvssci_2025_100290 crossref_primary_10_1038_s41467_023_43767_1 crossref_primary_10_1097_CM9_0000000000002644 crossref_primary_10_2174_0113862073294178240507091908 crossref_primary_10_1016_j_diabres_2024_111790 crossref_primary_10_1016_j_brainres_2025_149449 crossref_primary_10_1016_j_jstrokecerebrovasdis_2024_108136 crossref_primary_10_2147_CCID_S523231 crossref_primary_10_1016_j_ecoenv_2025_118089 crossref_primary_10_1002_jcsm_13575 crossref_primary_10_1038_s41588_025_02291_2 crossref_primary_10_1016_j_isci_2024_109961 crossref_primary_10_1038_s41467_023_38383_y crossref_primary_10_1038_s41586_023_06968_8 crossref_primary_10_3390_biomedicines13010231 crossref_primary_10_1007_s12035_025_04928_z crossref_primary_10_1016_j_isci_2023_106376 crossref_primary_10_3389_fimmu_2024_1442693 crossref_primary_10_1186_s12933_025_02738_0 crossref_primary_10_3390_antiox13080903 crossref_primary_10_1093_jncics_pkaf014 crossref_primary_10_1038_s42003_025_07453_w crossref_primary_10_3389_fneur_2024_1400557 crossref_primary_10_1016_j_exer_2024_110141 crossref_primary_10_3389_fphar_2024_1418560 crossref_primary_10_1016_j_ebiom_2024_105168 crossref_primary_10_1016_j_jad_2025_120047 crossref_primary_10_1007_s11262_025_02145_3 crossref_primary_10_3389_fimmu_2024_1289049 crossref_primary_10_1016_j_burns_2025_107667 crossref_primary_10_1016_j_scitotenv_2024_175633 crossref_primary_10_1038_s42003_024_06538_2 crossref_primary_10_1016_j_tig_2024_04_008 crossref_primary_10_1002_cai2_70004 crossref_primary_10_1038_s41598_025_88118_w crossref_primary_10_1161_ATVBAHA_125_323057 crossref_primary_10_1093_qjmed_hcaf108 crossref_primary_10_1038_s41598_025_13322_7 crossref_primary_10_1186_s12916_024_03298_y crossref_primary_10_1016_j_clnu_2025_08_024 crossref_primary_10_1212_WNL_0000000000209431 crossref_primary_10_1016_j_csbj_2024_04_040 crossref_primary_10_1038_s41467_024_49990_8 crossref_primary_10_1038_s41576_022_00511_7 crossref_primary_10_1186_s12967_023_04737_9 crossref_primary_10_1093_nar_gkad751 crossref_primary_10_1016_j_ajhg_2023_08_009 crossref_primary_10_1186_s12933_025_02670_3 crossref_primary_10_1016_j_jad_2025_120174 crossref_primary_10_1016_j_nbd_2025_106929 crossref_primary_10_3390_biomedicines12020327 crossref_primary_10_1093_hmg_ddaf036 crossref_primary_10_1016_j_ebiom_2023_104934 crossref_primary_10_1016_j_ajhg_2022_04_001 crossref_primary_10_1161_CIRCGEN_124_005125 crossref_primary_10_1097_MD_0000000000043198 crossref_primary_10_1002_alz_14429 crossref_primary_10_1038_s43587_024_00693_1 crossref_primary_10_1136_bmjmed_2023_000787 crossref_primary_10_1016_j_metabol_2023_155616 crossref_primary_10_1038_s41586_023_06592_6 crossref_primary_10_1186_s12883_025_04239_9 crossref_primary_10_1038_s41467_022_31757_8 crossref_primary_10_1186_s12885_023_11669_6 crossref_primary_10_1038_s41598_024_68448_x crossref_primary_10_1186_s41065_024_00362_8 crossref_primary_10_1210_clinem_dgad376 crossref_primary_10_1016_j_kint_2023_08_025 crossref_primary_10_1038_s41467_024_45382_0 crossref_primary_10_2147_IJWH_S522635 crossref_primary_10_1016_j_mayocp_2024_10_018 crossref_primary_10_1016_j_mayocp_2024_12_020 crossref_primary_10_3389_fgene_2024_1447872 crossref_primary_10_1016_j_heliyon_2024_e33433 crossref_primary_10_1161_ATVBAHA_122_318213 crossref_primary_10_1016_j_molmet_2022_101509 crossref_primary_10_1038_s41598_024_62069_0 crossref_primary_10_1186_s12864_022_08811_2 crossref_primary_10_1016_j_lfs_2025_123665 crossref_primary_10_1038_s41591_025_03872_8 crossref_primary_10_1007_s12672_025_03317_1 crossref_primary_10_1038_s41467_025_57879_3 crossref_primary_10_1126_sciadv_adt7176 crossref_primary_10_1038_s41598_025_85338_y crossref_primary_10_3389_fphar_2024_1428472 crossref_primary_10_1016_j_scib_2024_09_041 crossref_primary_10_1038_s41467_023_37729_w crossref_primary_10_1038_s43587_024_00682_4 crossref_primary_10_3389_fcvm_2022_991716 crossref_primary_10_3390_ijms26083608 crossref_primary_10_1093_cvr_cvae028 crossref_primary_10_1038_s41467_025_58310_7 crossref_primary_10_1177_0271678X241305916 crossref_primary_10_1002_cam4_70247 crossref_primary_10_1021_acs_jproteome_5c00148 crossref_primary_10_1098_rsob_230419 crossref_primary_10_1186_s13040_024_00405_w crossref_primary_10_1038_s42003_024_06755_9 crossref_primary_10_1021_acs_jproteome_5c00483 crossref_primary_10_1161_JAHA_121_024374 crossref_primary_10_1007_s00586_024_08551_9 crossref_primary_10_1038_s41598_024_80483_2 crossref_primary_10_1080_16583655_2025_2484879 crossref_primary_10_1186_s12944_024_02311_w crossref_primary_10_1038_s41698_025_00895_9 crossref_primary_10_1016_j_ajhg_2024_08_004 crossref_primary_10_1016_j_jacc_2022_06_006 crossref_primary_10_1038_s41467_024_50932_7 crossref_primary_10_1371_journal_pone_0323057 crossref_primary_10_1212_WNL_0000000000209585 crossref_primary_10_7189_jogh_15_04227 crossref_primary_10_3389_fcimb_2024_1386506 crossref_primary_10_1016_j_cell_2024_10_045 crossref_primary_10_1007_s12094_024_03680_5 crossref_primary_10_1038_s41467_023_40330_w crossref_primary_10_1038_s41598_024_78689_5 crossref_primary_10_1007_s12072_023_10608_8 crossref_primary_10_1038_s42003_024_06207_4 crossref_primary_10_1038_s41598_025_92800_4 crossref_primary_10_2147_CCID_S495217 crossref_primary_10_1038_s41598_024_62178_w crossref_primary_10_1038_s41598_024_57966_3 crossref_primary_10_1021_acs_jproteome_5c00494 crossref_primary_10_1038_s41598_025_86222_5 crossref_primary_10_1371_journal_pone_0322098 crossref_primary_10_1021_acs_analchem_5c00593 crossref_primary_10_2147_JMDH_S527449 crossref_primary_10_1038_s41590_023_01588_w crossref_primary_10_1136_svn_2025_004175 crossref_primary_10_1007_s00439_024_02684_z crossref_primary_10_1161_JAHA_123_031154 crossref_primary_10_1001_jamadermatol_2024_3779 crossref_primary_10_1038_s41467_025_59155_w crossref_primary_10_3389_fendo_2025_1534733 crossref_primary_10_1038_s42256_022_00525_0 crossref_primary_10_3389_fnagi_2024_1420731 crossref_primary_10_1016_j_arbres_2024_05_007 crossref_primary_10_1038_s42003_023_05454_1 crossref_primary_10_3350_cmh_2023_0343 crossref_primary_10_1016_j_bbih_2024_100754 crossref_primary_10_1016_j_jchf_2023_11_009 crossref_primary_10_1159_000542527 crossref_primary_10_1073_pnas_2425537122 crossref_primary_10_1016_j_ekir_2025_02_018 crossref_primary_10_1016_j_jhep_2024_03_035 crossref_primary_10_1038_s41588_025_02089_2 crossref_primary_10_1038_s44161_024_00545_6 crossref_primary_10_1186_s40659_025_00598_2 crossref_primary_10_3389_fnut_2024_1434648 crossref_primary_10_1016_j_ebiom_2023_104859 crossref_primary_10_1161_JAHA_124_037596 crossref_primary_10_1016_j_bbi_2024_07_002 crossref_primary_10_1038_s41416_025_03143_w crossref_primary_10_1186_s13073_024_01395_4 crossref_primary_10_1038_s41467_025_57829_z crossref_primary_10_1186_s13059_025_03671_x crossref_primary_10_1001_jamadermatol_2022_6051 crossref_primary_10_1038_s41467_022_29133_7 crossref_primary_10_1093_gastro_goaf057 crossref_primary_10_1186_s13578_024_01323_4 crossref_primary_10_1186_s40662_025_00442_4 crossref_primary_10_1016_j_xgen_2025_101004 crossref_primary_10_1038_s41467_024_53623_5 crossref_primary_10_3390_ph17060766 crossref_primary_10_1002_hsr2_70405 crossref_primary_10_1016_j_jnha_2024_100325 crossref_primary_10_1161_HYPERTENSIONAHA_125_24664 crossref_primary_10_3389_fimmu_2024_1391848 crossref_primary_10_1038_s41591_023_02420_6 crossref_primary_10_1371_journal_pone_0300500 crossref_primary_10_1016_j_jpba_2025_116731 crossref_primary_10_1186_s12884_025_07534_y crossref_primary_10_1016_j_coemr_2023_100470 crossref_primary_10_1093_jbmr_zjad011 crossref_primary_10_1002_ijc_35518 crossref_primary_10_1016_j_chembiol_2024_07_004 crossref_primary_10_2337_db22_0628 crossref_primary_10_1186_s12864_024_10412_0 crossref_primary_10_3389_fgene_2023_1161817 crossref_primary_10_1007_s00406_025_02117_6 crossref_primary_10_1080_16078454_2025_2545645 crossref_primary_10_1016_j_atherosclerosis_2024_117501 crossref_primary_10_1038_s41586_022_05165_3 crossref_primary_10_15252_emmm_202216359 crossref_primary_10_1111_1756_185X_70158 crossref_primary_10_1007_s10143_024_03070_z crossref_primary_10_1016_j_jad_2025_01_140 crossref_primary_10_1038_s41598_025_10318_1 crossref_primary_10_1080_01616412_2024_2448745 crossref_primary_10_1093_postmj_qgaf032 crossref_primary_10_1161_CIRCULATIONAHA_124_069864 crossref_primary_10_1186_s12890_024_03289_y crossref_primary_10_1016_j_jad_2025_119690 crossref_primary_10_1016_j_atherosclerosis_2024_118621 crossref_primary_10_1681_ASN_0000000000000434 crossref_primary_10_1177_13872877251345151 crossref_primary_10_3389_fimmu_2025_1597676 crossref_primary_10_1016_j_mcpro_2023_100550 crossref_primary_10_1007_s10557_025_07694_1 crossref_primary_10_1016_j_archger_2025_105788 crossref_primary_10_1038_s41467_023_36486_0 crossref_primary_10_1007_s00125_024_06267_5 crossref_primary_10_1038_s41467_023_42284_5 crossref_primary_10_3389_fendo_2024_1371498 crossref_primary_10_1016_j_jormas_2024_101836 crossref_primary_10_1111_liv_15905 crossref_primary_10_3390_biomedicines13010185 crossref_primary_10_1186_s40001_025_02752_8 crossref_primary_10_3389_fimmu_2024_1419363 crossref_primary_10_1093_eurheartj_ehad845 crossref_primary_10_1016_j_ajcnut_2025_07_015 crossref_primary_10_1016_j_intimp_2024_112051 crossref_primary_10_1016_j_bbi_2025_106101 crossref_primary_10_1038_s43856_025_00856_0 crossref_primary_10_1172_JCI181802 crossref_primary_10_1186_s13075_024_03348_z crossref_primary_10_1159_000543640 crossref_primary_10_3390_ijms26178690 crossref_primary_10_1038_s41467_022_35196_3 crossref_primary_10_1146_annurev_genom_021623_083207 crossref_primary_10_1038_s41588_023_01569_7 crossref_primary_10_1093_postmj_qgae182 crossref_primary_10_1177_02683555251337253 crossref_primary_10_1038_s43856_024_00530_x crossref_primary_10_3389_fendo_2024_1442483 crossref_primary_10_1038_s41588_022_01286_7 crossref_primary_10_1002_art_42753 crossref_primary_10_1016_j_heliyon_2024_e39013 crossref_primary_10_1080_14789450_2025_2529185 crossref_primary_10_1186_s12916_023_03197_8 crossref_primary_10_3389_fgene_2023_1191264 crossref_primary_10_1038_s42255_024_01008_9 crossref_primary_10_1007_s10067_024_07164_3 crossref_primary_10_1016_j_ajhg_2023_04_003 crossref_primary_10_1016_j_heliyon_2024_e39130 crossref_primary_10_1167_iovs_65_4_34 crossref_primary_10_1002_gepi_22578 crossref_primary_10_1681_ASN_0000000000000379 crossref_primary_10_1001_jama_2023_13258 crossref_primary_10_1016_j_cell_2025_04_040 crossref_primary_10_1016_j_jid_2025_04_032 crossref_primary_10_1161_CIRCULATIONAHA_122_061481 crossref_primary_10_1016_j_jad_2025_119471 crossref_primary_10_1080_0886022X_2025_2525473 crossref_primary_10_1161_ATVBAHA_125_322433 crossref_primary_10_1167_tvst_14_7_6 crossref_primary_10_1093_bib_bbaf250 crossref_primary_10_3390_ijms241411325 crossref_primary_10_2337_db23_0564 crossref_primary_10_3390_biomedicines13030622 crossref_primary_10_1038_s41598_025_12290_2 crossref_primary_10_3390_biomedicines13030749 crossref_primary_10_1016_j_ijbiomac_2025_143739 crossref_primary_10_1007_s44337_025_00475_7 crossref_primary_10_1016_j_jid_2024_04_023 crossref_primary_10_1038_s41467_025_61720_2 crossref_primary_10_1038_s41598_025_92210_6 crossref_primary_10_1016_j_ebiom_2022_104026 crossref_primary_10_3389_fnagi_2024_1322519 crossref_primary_10_1093_postmj_qgaf004 crossref_primary_10_1093_postmj_qgaf125 crossref_primary_10_1186_s12884_024_07077_8 crossref_primary_10_3390_biomedicines13061351 crossref_primary_10_1007_s12672_025_02307_7 crossref_primary_10_1371_journal_pone_0308301 crossref_primary_10_1007_s00216_024_05521_4 crossref_primary_10_1038_s43856_024_00474_2 crossref_primary_10_1016_j_ajhg_2024_12_010 crossref_primary_10_1038_s41588_023_01428_5 crossref_primary_10_1111_jcmm_70045 crossref_primary_10_1038_s41586_023_06563_x crossref_primary_10_1186_s12959_025_00733_9 crossref_primary_10_1007_s00240_025_01782_5 crossref_primary_10_1038_s42003_025_08738_w crossref_primary_10_1093_eurjpc_zwad020 crossref_primary_10_3389_fendo_2024_1406442 crossref_primary_10_7554_eLife_73951 crossref_primary_10_1016_j_bmt_2025_100102 crossref_primary_10_1016_j_thromres_2025_109376 crossref_primary_10_1080_14789450_2025_2468300 crossref_primary_10_1038_s10038_024_01234_9 crossref_primary_10_3389_fneur_2024_1431669 crossref_primary_10_1007_s12672_025_02775_x crossref_primary_10_1093_postmj_qgae140 crossref_primary_10_1038_s44161_025_00609_1 crossref_primary_10_1038_s41598_024_84116_6 crossref_primary_10_1016_j_surg_2025_109150 crossref_primary_10_1038_s41467_024_52470_8 crossref_primary_10_1681_ASN_0000000000000358 crossref_primary_10_1016_j_phymed_2025_157216 crossref_primary_10_3390_biomedicines13061380 crossref_primary_10_1038_s41598_025_16101_6 crossref_primary_10_1016_j_ecoenv_2025_118717 crossref_primary_10_1038_s42003_025_07860_z crossref_primary_10_1186_s12967_025_06366_w crossref_primary_10_1093_bib_bbaf032 crossref_primary_10_1038_s41588_022_01199_5 crossref_primary_10_3390_biomedicines12112562 crossref_primary_10_1371_journal_pmed_1003988 crossref_primary_10_1016_j_jjcc_2025_07_005 crossref_primary_10_1007_s40471_022_00295_8 crossref_primary_10_1136_ard_2023_224459 crossref_primary_10_1146_annurev_pharmtox_051421_111324 crossref_primary_10_1016_j_identj_2025_100934 crossref_primary_10_1186_s12967_024_06027_4 crossref_primary_10_1016_j_heliyon_2024_e38036 crossref_primary_10_1038_s43856_023_00307_8 crossref_primary_10_3390_ijms25052638 crossref_primary_10_1016_j_mcpro_2025_101071 crossref_primary_10_1161_CIRCHEARTFAILURE_121_009693 crossref_primary_10_1038_s41588_023_01525_5 crossref_primary_10_1186_s12937_025_01173_x crossref_primary_10_1186_s12885_024_12659_y crossref_primary_10_1016_j_bbadis_2024_167649 crossref_primary_10_1186_s12916_024_03249_7 crossref_primary_10_1186_s12967_024_05077_y crossref_primary_10_1007_s00403_024_03191_x crossref_primary_10_1007_s12672_025_03468_1 crossref_primary_10_1093_humrep_deae244 crossref_primary_10_3389_fonc_2024_1407795 crossref_primary_10_3389_fcimb_2024_1447327 crossref_primary_10_1038_s41586_023_06388_8 crossref_primary_10_1073_pnas_2319211121 crossref_primary_10_1136_gutjnl_2023_330967 crossref_primary_10_1186_s12959_025_00711_1 crossref_primary_10_3389_fnagi_2024_1423725 crossref_primary_10_1007_s12031_025_02347_2 crossref_primary_10_1016_j_jgg_2024_03_017 crossref_primary_10_3390_biomedicines12010162 crossref_primary_10_3389_fphar_2024_1448308 crossref_primary_10_1016_j_ijbiomac_2025_146096 crossref_primary_10_1093_hmg_ddac243 crossref_primary_10_1136_svn_2023_003076 crossref_primary_10_1007_s12672_025_02237_4 crossref_primary_10_1016_j_nbd_2022_105630 crossref_primary_10_1038_s41416_023_02419_3 crossref_primary_10_1002_dad2_12280 crossref_primary_10_1007_s12035_025_04977_4 crossref_primary_10_1016_j_diabres_2025_112246 crossref_primary_10_1177_0271678X251362977 crossref_primary_10_3389_fimmu_2024_1407431 crossref_primary_10_2337_db24_0380 crossref_primary_10_1097_JS9_0000000000000922 crossref_primary_10_1038_s41562_024_01963_z crossref_primary_10_1038_s42003_025_08046_3 crossref_primary_10_3390_cimb47030167 crossref_primary_10_5534_wjmh_240131 crossref_primary_10_1186_s12986_025_00925_0 crossref_primary_10_1186_s40246_024_00571_2 crossref_primary_10_1016_j_ajhg_2024_11_005 crossref_primary_10_1001_jamacardio_2025_0195 crossref_primary_10_1007_s00384_024_04744_2 crossref_primary_10_3390_gucdd3030015 crossref_primary_10_1016_j_jlr_2024_100526 crossref_primary_10_2337_db24_0262 crossref_primary_10_1016_j_atherosclerosis_2024_117462 crossref_primary_10_1093_bib_bbae353 crossref_primary_10_1016_j_isci_2024_111693 crossref_primary_10_3389_fendo_2024_1410463 crossref_primary_10_1016_j_jad_2024_10_053 crossref_primary_10_3389_fpsyt_2025_1414015 crossref_primary_10_1016_j_ijbiomac_2024_139394 crossref_primary_10_1007_s00223_022_01049_w crossref_primary_10_7554_eLife_84646 crossref_primary_10_1007_s12672_025_02636_7 crossref_primary_10_1186_s12916_023_02867_x crossref_primary_10_1007_s10067_024_07136_7 crossref_primary_10_1080_16078454_2025_2543619 crossref_primary_10_1038_s41598_025_94053_7 crossref_primary_10_1002_ijgo_70411 crossref_primary_10_1186_s12931_023_02587_z crossref_primary_10_1093_sexmed_qfae097 crossref_primary_10_1007_s12029_025_01226_8 crossref_primary_10_1016_j_ctmp_2025_200205 crossref_primary_10_1016_j_waojou_2025_101120 crossref_primary_10_1038_s41598_024_82567_5 crossref_primary_10_1155_2024_5566180 crossref_primary_10_1161_CIRCHEARTFAILURE_123_010849 crossref_primary_10_2147_JIR_S463450 crossref_primary_10_3389_fimmu_2024_1452801 crossref_primary_10_1161_CIRCULATIONAHA_125_074737 crossref_primary_10_1007_s44272_024_00024_w crossref_primary_10_1186_s12967_024_05604_x crossref_primary_10_1055_a_2484_0836 crossref_primary_10_1038_s42255_024_01133_5 crossref_primary_10_1038_s42003_024_07403_y crossref_primary_10_1038_s41588_023_01538_0 crossref_primary_10_1007_s00198_024_07225_y crossref_primary_10_1186_s41065_025_00457_w crossref_primary_10_1038_s41593_024_01610_w crossref_primary_10_1158_1055_9965_EPI_25_0165 crossref_primary_10_1097_MD_0000000000042681 crossref_primary_10_3389_fphar_2024_1439816 crossref_primary_10_1016_j_jad_2025_119734 crossref_primary_10_3390_ijms26136201 crossref_primary_10_1038_s41386_024_01807_4 crossref_primary_10_1016_j_advnut_2024_100344 crossref_primary_10_1186_s13148_025_01908_x crossref_primary_10_1186_s13024_025_00828_x crossref_primary_10_2337_db24_0168 crossref_primary_10_1126_sciadv_adr3757 crossref_primary_10_1161_CIRCULATIONAHA_123_064974 crossref_primary_10_1186_s12967_025_06465_8 crossref_primary_10_3389_fgene_2025_1631446 crossref_primary_10_1186_s13059_025_03480_2 crossref_primary_10_1038_s41467_024_52105_y crossref_primary_10_1038_s41467_023_38148_7 crossref_primary_10_1038_s43587_024_00655_7 crossref_primary_10_1007_s12672_025_02434_1 crossref_primary_10_1038_s41598_025_15525_4 crossref_primary_10_1080_0886022X_2024_2416087 crossref_primary_10_1186_s12916_023_03227_5 crossref_primary_10_3389_fmolb_2023_1340917 crossref_primary_10_1038_s41467_024_50007_7 crossref_primary_10_1177_13872877251344572 crossref_primary_10_1093_eurjpc_zwaf018 crossref_primary_10_1038_s41598_024_69180_2 crossref_primary_10_1016_j_psyneuen_2025_107418 crossref_primary_10_1186_s12967_024_05153_3 crossref_primary_10_1161_STROKEAHA_124_047103 crossref_primary_10_1017_thg_2024_19 crossref_primary_10_1016_j_jad_2025_03_116 crossref_primary_10_1016_j_rpth_2025_102955 crossref_primary_10_1161_CIRCGEN_124_004755 crossref_primary_10_1016_j_jacc_2023_09_804 crossref_primary_10_1038_s43587_024_00753_6 crossref_primary_10_1177_15579883251368307 crossref_primary_10_1097_MD_0000000000044628 crossref_primary_10_1167_iovs_66_12_22 crossref_primary_10_1007_s11883_022_01078_8 crossref_primary_10_1038_s41467_023_38389_6 crossref_primary_10_1038_s41598_024_62742_4 crossref_primary_10_1111_acel_14171 crossref_primary_10_1016_j_ajhg_2025_06_014 crossref_primary_10_1186_s12864_024_10116_5 crossref_primary_10_1038_s41598_024_77105_2 crossref_primary_10_1080_14789450_2025_2545828 crossref_primary_10_1038_s41588_023_01409_8 crossref_primary_10_3389_fimmu_2023_1238457 crossref_primary_10_1093_jnci_djaf137 crossref_primary_10_1016_j_sleep_2024_05_036 crossref_primary_10_1038_s41467_025_62126_w crossref_primary_10_1016_j_jacl_2025_01_003 crossref_primary_10_1093_ehjopen_oeae043 crossref_primary_10_1002_cam4_6022 crossref_primary_10_1016_j_jtha_2024_09_016 crossref_primary_10_1016_j_mcpro_2023_100565 crossref_primary_10_1016_j_ejphar_2024_176619 crossref_primary_10_1136_ard_2022_223468 crossref_primary_10_1186_s12967_024_05925_x crossref_primary_10_3389_fimmu_2024_1459465 crossref_primary_10_1093_biomtc_ujae082 crossref_primary_10_1016_j_jtha_2023_07_008 crossref_primary_10_1093_ije_dyae175 crossref_primary_10_1016_j_pnpbp_2024_111208 crossref_primary_10_3389_fgene_2023_1124431 crossref_primary_10_1016_j_jad_2025_03_065 crossref_primary_10_1161_JAHA_122_029003 crossref_primary_10_1016_j_ajhg_2023_02_008 crossref_primary_10_1016_j_ebiom_2023_104494 crossref_primary_10_2337_db24_0340 crossref_primary_10_1038_s41598_025_85900_8 crossref_primary_10_1016_j_heliyon_2024_e38334 crossref_primary_10_1038_s41598_025_07178_0 crossref_primary_10_1161_HYPERTENSIONAHA_124_24277 crossref_primary_10_1186_s12944_024_02328_1 crossref_primary_10_1038_s41598_025_04902_8 crossref_primary_10_1186_s12865_024_00677_1 crossref_primary_10_1186_s13073_024_01356_x crossref_primary_10_1038_s41467_024_44986_w crossref_primary_10_1007_s12672_025_02435_0 crossref_primary_10_1186_s12890_025_03751_5 crossref_primary_10_3390_biomedicines12061204 crossref_primary_10_34133_jbioxresearch_0052 crossref_primary_10_1038_s41467_024_46834_3 crossref_primary_10_1038_s41598_024_72281_7 crossref_primary_10_1016_j_identj_2024_04_019 crossref_primary_10_1161_HYPERTENSIONAHA_124_24151 crossref_primary_10_1016_j_isci_2023_106408 crossref_primary_10_1161_JAHA_124_037203 crossref_primary_10_1038_s41598_024_80697_4 crossref_primary_10_1093_ije_dyad093 crossref_primary_10_1016_j_ajhg_2024_04_020 crossref_primary_10_1161_CIRCGEN_124_004932 crossref_primary_10_1186_s12866_024_03423_0 crossref_primary_10_2337_db24_0451 crossref_primary_10_1007_s00240_024_01669_x crossref_primary_10_1038_s43856_025_00745_6 crossref_primary_10_1093_brain_awaf018 crossref_primary_10_3390_ph18040498 crossref_primary_10_1021_acs_jproteome_4c00956 crossref_primary_10_1111_exd_70161 crossref_primary_10_1038_s10038_024_01313_x crossref_primary_10_3390_ijms25179237 crossref_primary_10_1093_brain_awad070 crossref_primary_10_3389_fcvm_2024_1419440 crossref_primary_10_3389_fimmu_2024_1448476 crossref_primary_10_1002_advs_202411679 crossref_primary_10_1016_j_ijcard_2025_133746 crossref_primary_10_1155_cdr_5711316 crossref_primary_10_1161_ATVBAHA_125_322971 crossref_primary_10_1186_s12916_025_03848_y crossref_primary_10_1038_s41467_022_32319_8 crossref_primary_10_1038_s41467_023_41912_4 crossref_primary_10_1038_s41598_024_63399_9 crossref_primary_10_1038_s41380_024_02771_7 crossref_primary_10_1186_s12931_024_03086_5 crossref_primary_10_1161_JAHA_124_036202 crossref_primary_10_1186_s40246_024_00607_7 crossref_primary_10_1007_s12035_025_04967_6 crossref_primary_10_1016_j_diabres_2025_112474 crossref_primary_10_1007_s13258_025_01667_2 crossref_primary_10_1093_ajh_hpaf011 crossref_primary_10_1007_s10571_025_01583_9 crossref_primary_10_1016_j_ijid_2023_02_008 crossref_primary_10_3389_fmed_2024_1426261 crossref_primary_10_1186_s12967_024_04919_z crossref_primary_10_1111_acel_14266 crossref_primary_10_1097_MD_0000000000041549 crossref_primary_10_1038_s41467_022_33675_1 crossref_primary_10_1161_CIRCULATIONAHA_123_065866 crossref_primary_10_1007_s12672_024_01331_3 crossref_primary_10_1016_j_ebiom_2022_104199 crossref_primary_10_1111_adb_70045 crossref_primary_10_1111_jgh_16785 crossref_primary_10_1016_j_cmet_2023_07_012 crossref_primary_10_1002_hsr2_71285 crossref_primary_10_1016_j_ajhg_2024_10_008 crossref_primary_10_1111_1756_185x_70383 crossref_primary_10_1186_s12967_024_05363_9 crossref_primary_10_2147_JIR_S482047 crossref_primary_10_1016_j_diabres_2025_112237 crossref_primary_10_1111_jocd_70420 crossref_primary_10_1093_carcin_bgaf020 crossref_primary_10_1097_MD_0000000000043980 crossref_primary_10_1371_journal_pone_0329287 crossref_primary_10_1161_CIRCULATIONAHA_121_057888 crossref_primary_10_3389_fcvm_2023_1126208 crossref_primary_10_1016_j_wneu_2025_124015 crossref_primary_10_1038_s41467_023_43575_7 crossref_primary_10_1161_JAHA_124_036336 crossref_primary_10_1371_journal_pgen_1011821 crossref_primary_10_1038_s41398_025_03437_w crossref_primary_10_1093_ehjopen_oeae035 crossref_primary_10_1007_s12035_023_03206_0 crossref_primary_10_1097_MD_0000000000040467 crossref_primary_10_3390_biomedicines13092135 crossref_primary_10_1038_s41598_025_93068_4 crossref_primary_10_1186_s12967_024_05178_8 crossref_primary_10_1016_j_ebiom_2024_105530 crossref_primary_10_1007_s10067_025_07605_7 crossref_primary_10_1016_j_afos_2025_06_001 crossref_primary_10_1016_j_preteyeres_2022_101159 crossref_primary_10_1097_JS9_0000000000001925 crossref_primary_10_1038_s41416_023_02374_z crossref_primary_10_1038_s41598_025_94303_8 crossref_primary_10_1038_s44161_024_00475_3 crossref_primary_10_1186_s12885_025_14798_2 crossref_primary_10_1016_j_tem_2024_01_008 |
| Cites_doi | 10.1007/s003350020017 10.1038/nbt.3519 10.1038/382722a0 10.1038/ng.3247 10.1002/gepi.21758 10.1093/nar/gky1120 10.1038/ng.3359 10.1038/ng.3190 10.1097/WCO.0000000000000288 10.1038/s42255-020-00287-2 10.1038/s41586-018-0175-2 10.1038/s41586-020-2263-3 10.1038/ng.3654 10.1159/000475809 10.1093/bioinformatics/btx657 10.1038/s41467-018-05512-x 10.1126/science.1260419 10.1038/ng.2467 10.1038/s41467-020-19653-5 10.1172/JCI105794 10.1080/14767058.2018.1513483 10.1126/science.1062245 10.1038/s41467-020-19996-z 10.1074/mcp.M113.035600 10.1038/s41467-019-09775-w 10.1371/journal.pgen.1006706 10.1038/s41588-019-0519-3 10.1038/ng.3211 10.1093/nar/gkr424 10.1016/S1357-2725(99)00013-8 10.1126/science.aaq1327 10.1056/NEJMoa1211103 10.1038/ncomms14357 10.1186/s13059-016-0974-4 10.1038/s41467-018-07460-y 10.1038/ng.3643 10.1101/gad.7.3.454 10.1080/13543784.2016.1254615 10.1056/NEJMoa1508419 10.1093/nar/gky1131 10.1038/nrc1371 10.1053/j.gastro.2016.04.007 10.1093/ije/dyv080 10.1038/mtna.2014.49 10.1038/s41586-020-2436-0 10.1093/emboj/cdg038 10.1038/s41588-020-0682-6 10.1093/ije/dyx034 10.1038/ncomms15382 10.1038/88919 10.1007/978-1-4939-0897-4_9 10.1093/nar/gkz981 10.1038/s41576-020-0268-2 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature America, Inc. 2021 2021. The Author(s), under exclusive licence to Springer Nature America, Inc. Copyright Nature Publishing Group Dec 2021 |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature America, Inc. 2021 – notice: 2021. The Author(s), under exclusive licence to Springer Nature America, Inc. – notice: Copyright Nature Publishing Group Dec 2021 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 |
| DOI | 10.1038/s41588-021-00978-w |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database ProQuest Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture Biology |
| EISSN | 1546-1718 |
| EndPage | 1721 |
| ExternalDocumentID | 34857953 10_1038_s41588_021_00978_w |
| Genre | Journal Article |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABTAH ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LGEZI LK8 LOTEE M0L M1P M2O M7P MVM N9A NADUK NNMJJ NXXTH ODYON P2P PKN PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TN5 TSG TUS UKHRP VQA X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M ~KM AAYXX ABFSG ACSTC AETEA AEZWR AFANA AFFHD AFHIU AGSTI AHWEU AIEIU AIXLP ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 PUEGO |
| ID | FETCH-LOGICAL-c413t-4ad3f59d484e628dedd8ed92f64c26bd5d24b17db3b56aa659a440fff216074a3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 915 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000725465200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1061-4036 1546-1718 |
| IngestDate | Thu Oct 02 13:23:10 EDT 2025 Mon Oct 06 17:25:50 EDT 2025 Wed Feb 19 02:27:38 EST 2025 Sat Nov 29 03:07:11 EST 2025 Tue Nov 18 22:18:31 EST 2025 Fri Feb 21 02:39:07 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | 2021. The Author(s), under exclusive licence to Springer Nature America, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c413t-4ad3f59d484e628dedd8ed92f64c26bd5d24b17db3b56aa659a440fff216074a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-9517-6636 0000-0001-9392-6184 0000-0002-8545-3767 0000-0002-4606-5163 0000-0001-8339-150X 0000-0001-8593-4934 0000-0003-0756-0767 0000-0001-7067-9862 0000-0003-0491-7046 0000-0002-4732-7380 0000-0002-5222-9857 0000-0003-1846-6274 0000-0003-1676-864X 0000-0002-3806-2296 0000-0001-6571-423X 0000-0001-7123-6123 0000-0003-1009-7398 0000-0001-8090-7988 0000-0002-8223-8957 0000-0002-4376-3361 0000-0002-0461-040X 0000-0002-9331-6666 |
| PMID | 34857953 |
| PQID | 2608507778 |
| PQPubID | 33429 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2606923213 proquest_journals_2608507778 pubmed_primary_34857953 crossref_citationtrail_10_1038_s41588_021_00978_w crossref_primary_10_1038_s41588_021_00978_w springer_journals_10_1038_s41588_021_00978_w |
| PublicationCentury | 2000 |
| PublicationDate | 2021-12-01 |
| PublicationDateYYYYMMDD | 2021-12-01 |
| PublicationDate_xml | – month: 12 year: 2021 text: 2021-12-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Nature genetics |
| PublicationTitleAbbrev | Nat Genet |
| PublicationTitleAlternate | Nat Genet |
| PublicationYear | 2021 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Joshi (CR30) 2016; 151 Yao (CR7) 2018; 9 Rohloff (CR11) 2014; 3 Sennblad (CR16) 2017; 26 Memon (CR33) 2020; 33 Jin (CR38) 2017; 233 CR36 CR34 Law (CR17) 2019; 10 Loos (CR2) 2020; 11 Emilsson (CR5) 2018; 361 Zheng (CR9) 2020; 52 Magrinelli (CR45) 2020; 4 Jonsson (CR35) 2013; 368 Gudbjartsson (CR14) 2015; 47 Schröder, Harder (CR37) 1999; 31 Yavorska, Burgess (CR54) 2017; 46 Ragimbeau (CR25) 2003; 22 Loh (CR49) 2015; 47 Folkersen (CR8) 2020; 2 Lundberg, Eriksson, Tran, Assarsson, Fredriksson (CR12) 2011; 39 Rieder, Taourit, Mariat, Langlois, Guérin (CR20) 2001; 12 Fagerberg (CR29) 2014; 13 Bulik-Sullivan (CR50) 2015; 47 McLaren (CR51) 2016; 17 Szklarczyk (CR23) 2019; 47 CR40 Bray, Pimentel, Melsted, Pachter (CR52) 2016; 34 Rafnar (CR47) 2004; 4 Tsoi (CR57) 2017; 8 Klarin (CR15) 2019; 51 Howe (CR18) 2001; 28 Parman (CR43) 2016; 29 Tsoi (CR39) 2012; 44 Buniello (CR1) 2019; 47 Pietzner (CR46) 2020; 11 Miller (CR19) 1993; 7 Folkersen (CR6) 2017; 13 Saevarsdottir (CR48) 2020; 584 CR10 Spracklen (CR26) 2020; 582 Ferkingstad (CR31) 2018; 9 (CR27) 2016; 48 Galili, O’Callaghan, Sidi, Sievert (CR53) 2018; 34 Kim (CR42) 2016; 25 Bowden, Davey Smith, Burgess (CR56) 2015; 44 Liu (CR24) 2015; 47 Uhlén (CR28) 2015; 347 Samson (CR41) 1996; 382 CR22 Nioi (CR13) 2016; 374 Hammarström, Schneider, Kelly (CR44) 2001; 293 Burgess, Butterworth, Thompson (CR55) 2013; 37 Admirand, Small (CR32) 1968; 47 Suhre (CR3) 2017; 8 Surendran (CR21) 2016; 48 Sun (CR4) 2018; 558 P Surendran (978_CR21) 2016; 48 M Pietzner (978_CR46) 2020; 11 D Szklarczyk (978_CR23) 2019; 47 P Hammarström (978_CR44) 2001; 293 P-R Loh (978_CR49) 2015; 47 F Magrinelli (978_CR45) 2020; 4 M Uhlén (978_CR28) 2015; 347 K Suhre (978_CR3) 2017; 8 JZ Liu (978_CR24) 2015; 47 978_CR10 BK Bulik-Sullivan (978_CR50) 2015; 47 B Sennblad (978_CR16) 2017; 26 S Rieder (978_CR20) 2001; 12 JC Rohloff (978_CR11) 2014; 3 The Haplotype Reference Consortium. (978_CR27) 2016; 48 DF Gudbjartsson (978_CR14) 2015; 47 J Ragimbeau (978_CR25) 2003; 22 L Folkersen (978_CR6) 2017; 13 J Zheng (978_CR9) 2020; 52 T Rafnar (978_CR47) 2004; 4 P Nioi (978_CR13) 2016; 374 N Memon (978_CR33) 2020; 33 PJ Law (978_CR17) 2019; 10 L Fagerberg (978_CR29) 2014; 13 E Ferkingstad (978_CR31) 2018; 9 CN Spracklen (978_CR26) 2020; 582 978_CR22 M Lundberg (978_CR12) 2011; 39 S Burgess (978_CR55) 2013; 37 T Galili (978_CR53) 2018; 34 C Yao (978_CR7) 2018; 9 A Buniello (978_CR1) 2019; 47 978_CR36 Y Parman (978_CR43) 2016; 29 978_CR34 LC Tsoi (978_CR57) 2017; 8 OO Yavorska (978_CR54) 2017; 46 L Folkersen (978_CR8) 2020; 2 WH Admirand (978_CR32) 1968; 47 RJF Loos (978_CR2) 2020; 11 T Jonsson (978_CR35) 2013; 368 T Jin (978_CR38) 2017; 233 AD Joshi (978_CR30) 2016; 151 S Saevarsdottir (978_CR48) 2020; 584 978_CR40 LC Tsoi (978_CR39) 2012; 44 JM Schröder (978_CR37) 1999; 31 MW Miller (978_CR19) 1993; 7 JR Howe (978_CR18) 2001; 28 BB Sun (978_CR4) 2018; 558 M Samson (978_CR41) 1996; 382 MB Kim (978_CR42) 2016; 25 D Klarin (978_CR15) 2019; 51 W McLaren (978_CR51) 2016; 17 J Bowden (978_CR56) 2015; 44 V Emilsson (978_CR5) 2018; 361 NL Bray (978_CR52) 2016; 34 |
| References_xml | – volume: 12 start-page: 450 year: 2001 end-page: 455 ident: CR20 article-title: Mutations in the agouti ( ), the extension ( ), and the brown ( ) loci and their association to coat color phenotypes in horses ( ) publication-title: Mamm. Genome doi: 10.1007/s003350020017 – ident: CR22 – volume: 34 start-page: 525 year: 2016 end-page: 527 ident: CR52 article-title: Near-optimal probabilistic RNA-seq quantification publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3519 – volume: 382 start-page: 722 year: 1996 end-page: 725 ident: CR41 article-title: Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene publication-title: Nature doi: 10.1038/382722a0 – volume: 47 start-page: 435 year: 2015 end-page: 444 ident: CR14 article-title: Large-scale whole-genome sequencing of the Icelandic population publication-title: Nat. Genet. doi: 10.1038/ng.3247 – volume: 37 start-page: 658 year: 2013 end-page: 665 ident: CR55 article-title: Mendelian randomization analysis with multiple genetic variants using summarized data publication-title: Genet. Epidemiol. doi: 10.1002/gepi.21758 – volume: 47 start-page: D1005 year: 2019 end-page: D1012 ident: CR1 article-title: The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1120 – volume: 47 start-page: 979 year: 2015 end-page: 986 ident: CR24 article-title: Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations publication-title: Nat. Genet. doi: 10.1038/ng.3359 – volume: 47 start-page: 284 year: 2015 end-page: 290 ident: CR49 article-title: Efficient Bayesian mixed-model analysis increases association power in large cohorts publication-title: Nat. Genet. doi: 10.1038/ng.3190 – volume: 29 start-page: S3 year: 2016 end-page: S13 ident: CR43 article-title: Sixty years of transthyretin familial amyloid polyneuropathy (TTR-FAP) in Europe: where are we now? A European network approach to defining the epidemiology and management patterns for TTR-FAP publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0000000000000288 – volume: 2 start-page: 1135 year: 2020 end-page: 1148 ident: CR8 article-title: Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals publication-title: Nat. Metab. doi: 10.1038/s42255-020-00287-2 – volume: 558 start-page: 73 year: 2018 end-page: 79 ident: CR4 article-title: Genomic atlas of the human plasma proteome publication-title: Nature doi: 10.1038/s41586-018-0175-2 – volume: 582 start-page: 240 year: 2020 end-page: 245 ident: CR26 article-title: Identification of type 2 diabetes loci in 433,540 East Asian individuals publication-title: Nature doi: 10.1038/s41586-020-2263-3 – volume: 48 start-page: 1151 year: 2016 end-page: 1161 ident: CR21 article-title: Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension publication-title: Nat. Genet. doi: 10.1038/ng.3654 – volume: 233 start-page: 164 year: 2017 end-page: 169 ident: CR38 article-title: Serum human β-defensin-2 is a possible biomarker for monitoring response to JAK inhibitor in psoriasis patients publication-title: Dermatology doi: 10.1159/000475809 – volume: 4 start-page: CD012395 year: 2020 ident: CR45 article-title: Pharmacological treatment for familial amyloid polyneuropathy publication-title: Cochrane Database Syst. Rev. – volume: 34 start-page: 1600 year: 2018 end-page: 1602 ident: CR53 article-title: heatmaply: an R package for creating interactive cluster heatmaps for online publishing publication-title: Bioinformatics doi: 10.1093/bioinformatics/btx657 – volume: 9 year: 2018 ident: CR7 article-title: Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease publication-title: Nat. Commun. doi: 10.1038/s41467-018-05512-x – volume: 347 start-page: 1260419 year: 2015 ident: CR28 article-title: Proteomics. Tissue-based map of the human proteome publication-title: Science doi: 10.1126/science.1260419 – volume: 44 start-page: 1341 year: 2012 end-page: 1348 ident: CR39 article-title: Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity publication-title: Nat. Genet. doi: 10.1038/ng.2467 – volume: 11 year: 2020 ident: CR2 article-title: 15 years of genome-wide association studies and no signs of slowing down publication-title: Nat. Commun. doi: 10.1038/s41467-020-19653-5 – ident: CR36 – volume: 47 start-page: 1043–1052 year: 1968 ident: CR32 article-title: The physicochemical basis of cholesterol gallstone formation in man publication-title: J. Clin. Invest. doi: 10.1172/JCI105794 – volume: 33 start-page: 987 year: 2020 end-page: 992 ident: CR33 article-title: Developmental regulation of the gut–liver (FGF19–CYP7A1) axis in neonates publication-title: J. Matern. Fetal Neonatal Med. doi: 10.1080/14767058.2018.1513483 – volume: 293 start-page: 2459 year: 2001 end-page: 2462 ident: CR44 article-title: -suppression of misfolding in an amyloid disease publication-title: Science doi: 10.1126/science.1062245 – volume: 11 year: 2020 ident: CR46 article-title: Genetic architecture of host proteins involved in SARS-CoV-2 infection publication-title: Nat. Commun. doi: 10.1038/s41467-020-19996-z – volume: 13 start-page: 397 year: 2014 end-page: 406 ident: CR29 article-title: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M113.035600 – volume: 10 year: 2019 ident: CR17 article-title: Association analyses identify 31 new risk loci for colorectal cancer susceptibility publication-title: Nat. Commun. doi: 10.1038/s41467-019-09775-w – volume: 13 start-page: e1006706 year: 2017 ident: CR6 article-title: Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006706 – volume: 51 start-page: 1574 year: 2019 end-page: 1579 ident: CR15 article-title: Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease publication-title: Nat. Genet. doi: 10.1038/s41588-019-0519-3 – ident: CR10 – volume: 47 start-page: 291 year: 2015 end-page: 295 ident: CR50 article-title: LD Score regression distinguishes confounding from polygenicity in genome-wide association studies publication-title: Nat. Genet. doi: 10.1038/ng.3211 – volume: 39 start-page: e102 year: 2011 ident: CR12 article-title: Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr424 – volume: 31 start-page: 645 year: 1999 end-page: 651 ident: CR37 article-title: Human β-defensin-2 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/S1357-2725(99)00013-8 – volume: 361 start-page: 769 year: 2018 end-page: 773 ident: CR5 article-title: Co-regulatory networks of human serum proteins link genetics to disease publication-title: Science doi: 10.1126/science.aaq1327 – volume: 26 start-page: 637 year: 2017 end-page: 649 ident: CR16 article-title: Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels publication-title: Hum. Mol. Genet. – volume: 368 start-page: 107 year: 2013 end-page: 116 ident: CR35 article-title: Variant of associated with the risk of Alzheimer’s disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1211103 – volume: 8 year: 2017 ident: CR3 article-title: Connecting genetic risk to disease end points through the human blood plasma proteome publication-title: Nat. Commun. doi: 10.1038/ncomms14357 – volume: 17 year: 2016 ident: CR51 article-title: The Ensembl Variant Effect Predictor publication-title: Genome Biol. doi: 10.1186/s13059-016-0974-4 – ident: CR40 – volume: 9 year: 2018 ident: CR31 article-title: Genome-wide association meta-analysis yields 20 loci associated with gallstone disease publication-title: Nat. Commun. doi: 10.1038/s41467-018-07460-y – volume: 48 start-page: 1279 year: 2016 end-page: 1283 ident: CR27 article-title: A reference panel of 64,976 haplotypes for genotype imputation publication-title: Nat. Genet. doi: 10.1038/ng.3643 – volume: 7 start-page: 454 year: 1993 end-page: 467 ident: CR19 article-title: Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation publication-title: Genes Dev. doi: 10.1101/gad.7.3.454 – volume: 25 start-page: 1377 year: 2016 end-page: 1392 ident: CR42 article-title: CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV publication-title: Expert Opin. Investig. Drugs doi: 10.1080/13543784.2016.1254615 – volume: 374 start-page: 2131 year: 2016 end-page: 2141 ident: CR13 article-title: Variant associated with a reduced risk of coronary artery disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1508419 – volume: 47 start-page: D607 year: 2019 end-page: D613 ident: CR23 article-title: STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1131 – volume: 4 start-page: 488 year: 2004 end-page: 492 ident: CR47 article-title: The Icelandic Cancer Project—a population-wide approach to studying cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1371 – volume: 151 start-page: 351 year: 2016 end-page: 363 ident: CR30 article-title: Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.04.007 – volume: 44 start-page: 512 year: 2015 end-page: 525 ident: CR56 article-title: Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyv080 – volume: 3 start-page: e201 year: 2014 ident: CR11 article-title: Nucleic acid ligands with protein-like side chains: modified aptamers and their use as diagnostic and therapeutic agents publication-title: Mol. Ther. Nucleic Acids doi: 10.1038/mtna.2014.49 – volume: 584 start-page: 619 year: 2020 end-page: 623 ident: CR48 article-title: stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease publication-title: Nature doi: 10.1038/s41586-020-2436-0 – volume: 22 start-page: 537 year: 2003 end-page: 547 ident: CR25 article-title: The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression publication-title: EMBO J. doi: 10.1093/emboj/cdg038 – ident: CR34 – volume: 52 start-page: 1122 year: 2020 end-page: 1131 ident: CR9 article-title: Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases publication-title: Nat. Genet. doi: 10.1038/s41588-020-0682-6 – volume: 46 start-page: 1734 year: 2017 end-page: 1739 ident: CR54 article-title: MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyx034 – volume: 8 year: 2017 ident: CR57 article-title: Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants publication-title: Nat. Commun. doi: 10.1038/ncomms15382 – volume: 28 start-page: 184 year: 2001 end-page: 187 ident: CR18 article-title: Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis publication-title: Nat. Genet. doi: 10.1038/88919 – volume: 26 start-page: 637 year: 2017 ident: 978_CR16 publication-title: Hum. Mol. Genet. – volume: 293 start-page: 2459 year: 2001 ident: 978_CR44 publication-title: Science doi: 10.1126/science.1062245 – volume: 22 start-page: 537 year: 2003 ident: 978_CR25 publication-title: EMBO J. doi: 10.1093/emboj/cdg038 – volume: 347 start-page: 1260419 year: 2015 ident: 978_CR28 publication-title: Science doi: 10.1126/science.1260419 – volume: 8 year: 2017 ident: 978_CR57 publication-title: Nat. Commun. doi: 10.1038/ncomms15382 – volume: 584 start-page: 619 year: 2020 ident: 978_CR48 publication-title: Nature doi: 10.1038/s41586-020-2436-0 – volume: 8 year: 2017 ident: 978_CR3 publication-title: Nat. Commun. doi: 10.1038/ncomms14357 – volume: 361 start-page: 769 year: 2018 ident: 978_CR5 publication-title: Science doi: 10.1126/science.aaq1327 – volume: 10 year: 2019 ident: 978_CR17 publication-title: Nat. Commun. doi: 10.1038/s41467-019-09775-w – volume: 11 year: 2020 ident: 978_CR46 publication-title: Nat. Commun. doi: 10.1038/s41467-020-19996-z – volume: 31 start-page: 645 year: 1999 ident: 978_CR37 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/S1357-2725(99)00013-8 – volume: 558 start-page: 73 year: 2018 ident: 978_CR4 publication-title: Nature doi: 10.1038/s41586-018-0175-2 – ident: 978_CR34 doi: 10.1007/978-1-4939-0897-4_9 – volume: 47 start-page: 291 year: 2015 ident: 978_CR50 publication-title: Nat. Genet. doi: 10.1038/ng.3211 – volume: 39 start-page: e102 year: 2011 ident: 978_CR12 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr424 – volume: 25 start-page: 1377 year: 2016 ident: 978_CR42 publication-title: Expert Opin. Investig. Drugs doi: 10.1080/13543784.2016.1254615 – volume: 582 start-page: 240 year: 2020 ident: 978_CR26 publication-title: Nature doi: 10.1038/s41586-020-2263-3 – volume: 4 start-page: CD012395 year: 2020 ident: 978_CR45 publication-title: Cochrane Database Syst. Rev. – volume: 2 start-page: 1135 year: 2020 ident: 978_CR8 publication-title: Nat. Metab. doi: 10.1038/s42255-020-00287-2 – volume: 47 start-page: D607 year: 2019 ident: 978_CR23 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1131 – volume: 151 start-page: 351 year: 2016 ident: 978_CR30 publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.04.007 – volume: 7 start-page: 454 year: 1993 ident: 978_CR19 publication-title: Genes Dev. doi: 10.1101/gad.7.3.454 – volume: 233 start-page: 164 year: 2017 ident: 978_CR38 publication-title: Dermatology doi: 10.1159/000475809 – volume: 44 start-page: 1341 year: 2012 ident: 978_CR39 publication-title: Nat. Genet. doi: 10.1038/ng.2467 – volume: 13 start-page: 397 year: 2014 ident: 978_CR29 publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M113.035600 – volume: 12 start-page: 450 year: 2001 ident: 978_CR20 publication-title: Mamm. Genome doi: 10.1007/s003350020017 – volume: 33 start-page: 987 year: 2020 ident: 978_CR33 publication-title: J. Matern. Fetal Neonatal Med. doi: 10.1080/14767058.2018.1513483 – volume: 34 start-page: 525 year: 2016 ident: 978_CR52 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3519 – volume: 47 start-page: 1043–1052 year: 1968 ident: 978_CR32 publication-title: J. Clin. Invest. doi: 10.1172/JCI105794 – volume: 44 start-page: 512 year: 2015 ident: 978_CR56 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyv080 – volume: 47 start-page: 435 year: 2015 ident: 978_CR14 publication-title: Nat. Genet. doi: 10.1038/ng.3247 – volume: 47 start-page: 284 year: 2015 ident: 978_CR49 publication-title: Nat. Genet. doi: 10.1038/ng.3190 – volume: 48 start-page: 1151 year: 2016 ident: 978_CR21 publication-title: Nat. Genet. doi: 10.1038/ng.3654 – volume: 52 start-page: 1122 year: 2020 ident: 978_CR9 publication-title: Nat. Genet. doi: 10.1038/s41588-020-0682-6 – volume: 47 start-page: 979 year: 2015 ident: 978_CR24 publication-title: Nat. Genet. doi: 10.1038/ng.3359 – volume: 382 start-page: 722 year: 1996 ident: 978_CR41 publication-title: Nature doi: 10.1038/382722a0 – volume: 3 start-page: e201 year: 2014 ident: 978_CR11 publication-title: Mol. Ther. Nucleic Acids doi: 10.1038/mtna.2014.49 – volume: 34 start-page: 1600 year: 2018 ident: 978_CR53 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btx657 – volume: 13 start-page: e1006706 year: 2017 ident: 978_CR6 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006706 – volume: 48 start-page: 1279 year: 2016 ident: 978_CR27 publication-title: Nat. Genet. doi: 10.1038/ng.3643 – volume: 17 year: 2016 ident: 978_CR51 publication-title: Genome Biol. doi: 10.1186/s13059-016-0974-4 – volume: 374 start-page: 2131 year: 2016 ident: 978_CR13 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1508419 – volume: 29 start-page: S3 year: 2016 ident: 978_CR43 publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0000000000000288 – volume: 51 start-page: 1574 year: 2019 ident: 978_CR15 publication-title: Nat. Genet. doi: 10.1038/s41588-019-0519-3 – ident: 978_CR40 doi: 10.1093/nar/gkz981 – volume: 28 start-page: 184 year: 2001 ident: 978_CR18 publication-title: Nat. Genet. doi: 10.1038/88919 – volume: 368 start-page: 107 year: 2013 ident: 978_CR35 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1211103 – ident: 978_CR36 – volume: 11 year: 2020 ident: 978_CR2 publication-title: Nat. Commun. doi: 10.1038/s41467-020-19653-5 – volume: 9 year: 2018 ident: 978_CR7 publication-title: Nat. Commun. doi: 10.1038/s41467-018-05512-x – volume: 47 start-page: D1005 year: 2019 ident: 978_CR1 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1120 – volume: 37 start-page: 658 year: 2013 ident: 978_CR55 publication-title: Genet. Epidemiol. doi: 10.1002/gepi.21758 – volume: 9 year: 2018 ident: 978_CR31 publication-title: Nat. Commun. doi: 10.1038/s41467-018-07460-y – ident: 978_CR10 doi: 10.1038/s41576-020-0268-2 – ident: 978_CR22 – volume: 4 start-page: 488 year: 2004 ident: 978_CR47 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1371 – volume: 46 start-page: 1734 year: 2017 ident: 978_CR54 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyx034 |
| SSID | ssj0014408 |
| Score | 2.7474847 |
| Snippet | The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels... The proteome also introduces a new temporal quality: the levels of proteins may rise or fall as a function of time before or after an event or as disease... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1712 |
| SubjectTerms | 45/23 45/43 45/91 631/114/2784 631/208/205/2138 692/308/2056 82/47 82/79 82/80 Agriculture Animal Genetics and Genomics Aptamers Biomarkers Biomarkers - blood Biomedical and Life Sciences Biomedicine Blood Proteins - genetics Blood Proteins - metabolism Cancer Research Disease Disease - genetics Female Gene expression Gene Frequency Gene Function Genetic Variation Genetics Genome-Wide Association Study Genomes Genomics Human Genetics Humans Male Middle Aged Pathogenesis Plasma Plasma proteins Proteins Proteome - genetics Proteomes Quantitative Trait Loci |
| Title | Large-scale integration of the plasma proteome with genetics and disease |
| URI | https://link.springer.com/article/10.1038/s41588-021-00978-w https://www.ncbi.nlm.nih.gov/pubmed/34857953 https://www.proquest.com/docview/2608507778 https://www.proquest.com/docview/2606923213 |
| Volume | 53 |
| WOSCitedRecordID | wos000725465200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1546-1718 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: M7P dateStart: 20000101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1546-1718 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: 7X7 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1546-1718 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: BENPR dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest_Research Library customDbUrl: eissn: 1546-1718 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: M2O dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1546-1718 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: 8C1 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEB7yaCGXJn2lm8eiQm-tSCzJknwqSUjIId0upYW9Gb0MgcTexpuG_vuOZHtDCcklF4GRbAt9I81I32gG4JPwgXMpDqlTuF0V2IwWPAiqgpHOcuVU0SWbUJOJns2KaX_g1vZulcOamBZq37h4Rn6AdrdG20Up_XX-m8asUZFd7VNorMJ6jJLAk-vedMkixGzKie2UcZ8Uacqd7pq5PmhRcaGMRAeFdJWB3v2vmB5Ymw-Y0qSAzjaf2_UteNWbnuSok5XXsBLqN_CyS0b59y2cX0SncNoiaIEMUSQQNdJUBK1EMkc7-9qQFNihuQ4knuASFL94C7IlpvakJ3vewa-z058n57TPs0AdqrAFFcbzKi-80CJIpn3wXgdfsEoKx6T1uWfCZspbbnNpjMwLgyNbVRWL0emE4e9hrW7q8AGIDdaqgjGX-0pY47XNKuaFMsLmCgVhBNkwyKXrg5DHXBhXZSLDuS47YEoEpkzAlHcj-Lx8Z96F4Hiy9d4AQtlPx7a8R2AEH5fVOJEiO2Lq0NymNhKtXZbxEWx3mC9_x4XOVZFjzZdBCO4__nhfdp7uyy5ssCiAyTlmD9YWN7dhH164P4vL9mYMq2qmUqmx1CfZGNaPTyfTH_j0jX0fJ1H_BxYm_m4 |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL78eWAkaCE7XatR3bOSCEgGqrLqseitSb8SsSEk2WZsuqf4rfyNhJtkIVvfXA2Y7jZD6Px_7mAfBahMi5FDvUKzyuCuxGSx4FVdFK77jyquyKTajZTB8dlQdr8HuIhUlulYNOzIo6ND7dkW-j3a3RdlFKv5__pKlqVGJXhxIaHSz249kSj2ztu71PKN83jO1-Pvw4oX1VAepRYS-osIFXRRmEFlEyHWIIOoaSVVJ4Jl0oAhNurILjrpDWyqK0QuxUVcVSLjZhOY57Da6jGcF0dhU8WLEWqXpzZldlOpclWnSjC2vX2y1ulIjJ5BCRQyfo8u-N8IJ1e4GZzRve7t3_7Vfdgzu9aU0-dGvhPqzF-gHc7Iptnj2EyTQ5vdMWQRnJkCUDUUmaiqAVTOZ4jji2JCeuaI4jSTfUBJdXivJsia0D6cmsR_D1Sj7jMazXTR2fAnHROVUy5otQCWeDduOKBaGscIVCoI9gPAjV-D7Jeqr18cNksp9r0wHBIBBMBoJZjuDt6pl5l2Lk0t6bg9BNr25acy7xEbxaNaOiSOyPrWNzmvtItObZmI_gSYex1eu40IUqC2zZGkB3Pvi_57Jx-Vxewq3J4Zepme7N9p_BbZbAnx2BNmF9cXIan8MN_2vxvT15kZcRgW9XDcY_bfpXsQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8hAX3o8tBYwEJ2pt13Zs54AQalm1arXqAaTejF-RkGiyNFtW_Wv8OsZOshWq6K0HznYcJ_PNeMbzAngrQuRcim3qFZqrAqfRkkdBVbTSO668KrtmE2o208fH5dEa_B5yYVJY5SATs6AOjU935GPUuzXqLkrpcdWHRRztTj_Of9LUQSp5Wod2Gh1EDuL5Es239sP-LtL6HWPTz1929mjfYYB6FN4LKmzgVVEGoUWUTIcYgo6hZJUUnkkXisCEm6jguCuktbIorRDbVVWxVJdNWI7r3oCbiiOKU5b6ziq8JPlMuzQ8mWy05CLd6FLc9bjFQxPxmYIjchoFXf59KF7SdC95afPhN73_P_-2B3CvV7nJp45HHsJarB_B7a4J5_lj2DtMwfC0RbBGMlTPQLSSpiKoHZM52hcnluSCFs1JJOnmmiDbpezPltg6kN7J9QS-XstnPIX1uqnjcyAuOqdKxnwRKuFs0G5SsSCUFa5QyAAjmAwENr4vvp56gPwwOQiAa9OBwiAoTAaFWY7g_eqZeVd65MrZmwMATC-GWnNB_RG8WQ2jAEleIVvH5izPkajlswkfwbMOb6vXcaELVRY4sjUA8GLxf-9l4-q9vIY7iEFzuD87eAF3WeKDHB-0CeuL07P4Em75X4vv7emrzFEEvl03Fv8Aj3ZgJw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Large-scale+integration+of+the+plasma+proteome+with+genetics+and+disease&rft.jtitle=Nature+genetics&rft.au=Ferkingstad%2C+Egil&rft.au=Sulem%2C+Patrick&rft.au=Atlason%2C+Bjarni+A&rft.au=Sveinbjornsson%2C+Gardar&rft.date=2021-12-01&rft.eissn=1546-1718&rft.volume=53&rft.issue=12&rft.spage=1712&rft_id=info:doi/10.1038%2Fs41588-021-00978-w&rft_id=info%3Apmid%2F34857953&rft.externalDocID=34857953 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon |