An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence
Plants deploy a variety of secondary metabolites to fend off pathogen attack. Although defense compounds are generally considered toxic to microbes, the exact mechanisms are often unknown. Here, we show that the Arabidopsis defense compound sulforaphane (SFN) functions primarily by inhibiting Pseudo...
Saved in:
| Published in: | Cell host & microbe Vol. 27; no. 4; p. 601 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
08.04.2020
|
| Subjects: | |
| ISSN: | 1934-6069, 1934-6069 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Plants deploy a variety of secondary metabolites to fend off pathogen attack. Although defense compounds are generally considered toxic to microbes, the exact mechanisms are often unknown. Here, we show that the Arabidopsis defense compound sulforaphane (SFN) functions primarily by inhibiting Pseudomonas syringae type III secretion system (TTSS) genes, which are essential for pathogenesis. Plants lacking the aliphatic glucosinolate pathway, which do not accumulate SFN, were unable to attenuate TTSS gene expression and exhibited increased susceptibility to P. syringae strains that cannot detoxify SFN. Chemoproteomics analyses showed that SFN covalently modified the cysteine at position 209 of HrpS, a key transcription factor controlling TTSS gene expression. Site-directed mutagenesis and functional analyses further confirmed that Cys209 was responsible for bacterial sensitivity to SFN in vitro and sensitivity to plant defenses conferred by the aliphatic glucosinolate pathway. Collectively, these results illustrate a previously unknown mechanism by which plants disarm a pathogenic bacterium. |
|---|---|
| AbstractList | Plants deploy a variety of secondary metabolites to fend off pathogen attack. Although defense compounds are generally considered toxic to microbes, the exact mechanisms are often unknown. Here, we show that the Arabidopsis defense compound sulforaphane (SFN) functions primarily by inhibiting Pseudomonas syringae type III secretion system (TTSS) genes, which are essential for pathogenesis. Plants lacking the aliphatic glucosinolate pathway, which do not accumulate SFN, were unable to attenuate TTSS gene expression and exhibited increased susceptibility to P. syringae strains that cannot detoxify SFN. Chemoproteomics analyses showed that SFN covalently modified the cysteine at position 209 of HrpS, a key transcription factor controlling TTSS gene expression. Site-directed mutagenesis and functional analyses further confirmed that Cys209 was responsible for bacterial sensitivity to SFN in vitro and sensitivity to plant defenses conferred by the aliphatic glucosinolate pathway. Collectively, these results illustrate a previously unknown mechanism by which plants disarm a pathogenic bacterium.Plants deploy a variety of secondary metabolites to fend off pathogen attack. Although defense compounds are generally considered toxic to microbes, the exact mechanisms are often unknown. Here, we show that the Arabidopsis defense compound sulforaphane (SFN) functions primarily by inhibiting Pseudomonas syringae type III secretion system (TTSS) genes, which are essential for pathogenesis. Plants lacking the aliphatic glucosinolate pathway, which do not accumulate SFN, were unable to attenuate TTSS gene expression and exhibited increased susceptibility to P. syringae strains that cannot detoxify SFN. Chemoproteomics analyses showed that SFN covalently modified the cysteine at position 209 of HrpS, a key transcription factor controlling TTSS gene expression. Site-directed mutagenesis and functional analyses further confirmed that Cys209 was responsible for bacterial sensitivity to SFN in vitro and sensitivity to plant defenses conferred by the aliphatic glucosinolate pathway. Collectively, these results illustrate a previously unknown mechanism by which plants disarm a pathogenic bacterium. Plants deploy a variety of secondary metabolites to fend off pathogen attack. Although defense compounds are generally considered toxic to microbes, the exact mechanisms are often unknown. Here, we show that the Arabidopsis defense compound sulforaphane (SFN) functions primarily by inhibiting Pseudomonas syringae type III secretion system (TTSS) genes, which are essential for pathogenesis. Plants lacking the aliphatic glucosinolate pathway, which do not accumulate SFN, were unable to attenuate TTSS gene expression and exhibited increased susceptibility to P. syringae strains that cannot detoxify SFN. Chemoproteomics analyses showed that SFN covalently modified the cysteine at position 209 of HrpS, a key transcription factor controlling TTSS gene expression. Site-directed mutagenesis and functional analyses further confirmed that Cys209 was responsible for bacterial sensitivity to SFN in vitro and sensitivity to plant defenses conferred by the aliphatic glucosinolate pathway. Collectively, these results illustrate a previously unknown mechanism by which plants disarm a pathogenic bacterium. |
| Author | Liu, Yong-Xin Wang, Wei Gao, Chulei Miao, Pei Li, Jiayang Lei, Xiaoguang Zhang, Jian Zhang, Xiaojuan Zhou, Jian-Min Chu, Jinfang Zhang, Wenjing Qu, Baoyuan Zuo, Jianru Xin, Peiyong Bai, Yang Yang, Jing Tian, Caiping Cheng, Shujing Li, Lei |
| Author_xml | – sequence: 1 givenname: Wei surname: Wang fullname: Wang, Wei organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 2 givenname: Jing surname: Yang fullname: Yang, Jing organization: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Lifeomics, Beijing 102206, China – sequence: 3 givenname: Jian surname: Zhang fullname: Zhang, Jian organization: Department of Chemical Biology, College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China – sequence: 4 givenname: Yong-Xin surname: Liu fullname: Liu, Yong-Xin organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (CAS), Beijing 100101, China – sequence: 5 givenname: Caiping surname: Tian fullname: Tian, Caiping organization: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Lifeomics, Beijing 102206, China – sequence: 6 givenname: Baoyuan surname: Qu fullname: Qu, Baoyuan organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (CAS), Beijing 100101, China – sequence: 7 givenname: Chulei surname: Gao fullname: Gao, Chulei organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 8 givenname: Peiyong surname: Xin fullname: Xin, Peiyong organization: National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 9 givenname: Shujing surname: Cheng fullname: Cheng, Shujing organization: National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 10 givenname: Wenjing surname: Zhang fullname: Zhang, Wenjing organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 11 givenname: Pei surname: Miao fullname: Miao, Pei organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 12 givenname: Lei surname: Li fullname: Li, Lei organization: Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany – sequence: 13 givenname: Xiaojuan surname: Zhang fullname: Zhang, Xiaojuan organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China – sequence: 14 givenname: Jinfang surname: Chu fullname: Chu, Jinfang organization: National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 15 givenname: Jianru surname: Zuo fullname: Zuo, Jianru organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 16 givenname: Jiayang surname: Li fullname: Li, Jiayang organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 17 givenname: Yang surname: Bai fullname: Bai, Yang organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China; CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (CAS), Beijing 100101, China – sequence: 18 givenname: Xiaoguang surname: Lei fullname: Lei, Xiaoguang email: xglei@pku.edu.cn organization: Department of Chemical Biology, College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: xglei@pku.edu.cn – sequence: 19 givenname: Jian-Min surname: Zhou fullname: Zhou, Jian-Min email: jmzhou@genetics.ac.cn organization: State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: jmzhou@genetics.ac.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32272078$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkLtOwzAYhS1URC_wAgzII0uCL7l5LKVApCKGFtbIdf5QV0kcbEcij8Bb0wqQOp2jo0_fcKZo1JoWELqmJKSEJnf7UO1MEzLCSEh4SEh0hiZU8ChISCJGJ32Mps7tCYljktILNOaMpYyk2QR9z1s8t3KrS9M57fAalGlLaQf8Al5uTa094AdtQfl6wBtpP8A7vPzqLDinTYtNhf0O8L1UHqyWNd4MHeA8z48qC_7IrAfnocHe4Lzd6a32J_i7tn0NrYJLdF7J2sHVX87Q2-Nys3gOVq9P-WK-ClREuQ9opkSlOKRKCEpjSGJVCojKOBZEcV5RHlVUlFmsEsrLw0IznlYVMCIoU7FgM3T76-2s-ezB-aLRTkFdyxZM7wrGsyxjJGPRAb35Q_ttA2XRWd0crin-72M_01t1yA |
| CitedBy_id | crossref_primary_10_1111_mpp_13496 crossref_primary_10_1088_1755_1315_949_1_012049 crossref_primary_10_3390_biom14030352 crossref_primary_10_1146_annurev_micro_022620_014327 crossref_primary_10_1016_j_molp_2023_04_004 crossref_primary_10_1111_nph_70254 crossref_primary_10_1038_s41467_024_52679_7 crossref_primary_10_1186_s13213_022_01696_2 crossref_primary_10_15252_embr_202152805 crossref_primary_10_1016_j_molp_2022_12_006 crossref_primary_10_1016_j_pestbp_2023_105471 crossref_primary_10_1002_npp2_70012 crossref_primary_10_1360_SSV_2025_0063 crossref_primary_10_1039_D1EN00558H crossref_primary_10_1126_science_ads0377 crossref_primary_10_3390_plants13101329 crossref_primary_10_1094_MPMI_34_7 crossref_primary_10_1111_pce_14870 crossref_primary_10_3389_fpls_2020_00886 crossref_primary_10_1007_s12275_022_2284_8 crossref_primary_10_1094_PHYTO_09_21_0404_R crossref_primary_10_1093_plphys_kiad184 crossref_primary_10_1186_s42483_024_00304_2 crossref_primary_10_3390_microorganisms9061227 crossref_primary_10_1146_annurev_phyto_021621_114026 crossref_primary_10_1038_s41467_025_60068_x crossref_primary_10_1111_mpp_13340 crossref_primary_10_1111_nph_19479 crossref_primary_10_1002_bab_2400 crossref_primary_10_1016_j_apsoil_2022_104445 crossref_primary_10_1016_j_cbpa_2023_102351 crossref_primary_10_1038_s41596_020_0352_2 crossref_primary_10_1094_PHYTO_08_22_0292_KD crossref_primary_10_1016_j_pmpp_2023_101978 crossref_primary_10_3389_fpls_2021_621276 crossref_primary_10_1038_s41596_020_00444_7 crossref_primary_10_1111_ppl_13922 crossref_primary_10_1016_j_cclet_2024_110044 crossref_primary_10_1038_s44319_023_00023_3 crossref_primary_10_1016_j_plaphy_2024_109224 crossref_primary_10_1242_jcs_252023 crossref_primary_10_1038_s41467_024_44724_2 crossref_primary_10_1038_s41589_022_01074_8 crossref_primary_10_1128_msystems_00437_23 crossref_primary_10_3390_plants11131742 crossref_primary_10_1093_plcell_koaf186 crossref_primary_10_1016_j_pmpp_2025_102858 crossref_primary_10_1111_mpp_13314 crossref_primary_10_1038_s41467_025_61266_3 crossref_primary_10_1111_mpp_70110 crossref_primary_10_1094_PHYTO_01_21_0035_RVW crossref_primary_10_1002_pld3_437 crossref_primary_10_1016_j_jare_2024_10_002 crossref_primary_10_26599_FMH_2025_9420060 crossref_primary_10_1016_j_csbj_2020_10_039 crossref_primary_10_1111_mpp_13245 crossref_primary_10_1094_MPMI_09_20_0261_R crossref_primary_10_1016_j_pbi_2023_102459 crossref_primary_10_1042_EBC20220159 crossref_primary_10_1016_j_hpj_2023_04_005 crossref_primary_10_1128_spectrum_03330_23 crossref_primary_10_1002_imo2_42 crossref_primary_10_1007_s44154_024_00152_2 crossref_primary_10_1186_s42483_025_00320_w crossref_primary_10_1016_j_pestbp_2021_104948 crossref_primary_10_1111_mpp_13048 crossref_primary_10_1186_s12014_022_09360_2 crossref_primary_10_3389_fmicb_2020_571217 crossref_primary_10_1038_s41422_025_01111_w crossref_primary_10_3390_app12094101 crossref_primary_10_1146_annurev_phyto_010824_023359 crossref_primary_10_1007_s13238_020_00724_8 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2020 Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.chom.2020.03.004 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1934-6069 |
| ExternalDocumentID | 32272078 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 5GY 62- 6J9 7-5 AAEDT AAEDW AAKRW AALRI AAMRU AAVLU AAXUO AAYWO ABDGV ABJNI ABMAC ACGFO ACGFS ACVFH ADBBV ADCNI ADEZE ADVLN AEFWE AENEX AEUPX AEXQZ AFPUW AFTJW AGCQF AGKMS AIGII AITUG AKAPO AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EFKBS EIF EJD F5P FCP FDB FEDTE HVGLF IHE IXB JIG M41 NPM O-L O9- OK1 P2P ROL RPZ SES SSZ TR2 UNMZH 7X8 |
| ID | FETCH-LOGICAL-c413t-18c9fc3e7c99115e65cd9e4d5590c33f134f19d85c613dc331837ffe20912c592 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 72 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000525735600015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1934-6069 |
| IngestDate | Thu Oct 02 16:03:58 EDT 2025 Mon Jul 21 05:47:38 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | defense compound glucosinolate Arabidopsis Pseudomonas syringae Type III Secretion System |
| Language | English |
| License | Copyright © 2020 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c413t-18c9fc3e7c99115e65cd9e4d5590c33f134f19d85c613dc331837ffe20912c592 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://www.cell.com/article/S1931312820301682/pdf |
| PMID | 32272078 |
| PQID | 2388820824 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2388820824 pubmed_primary_32272078 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-04-08 |
| PublicationDateYYYYMMDD | 2020-04-08 |
| PublicationDate_xml | – month: 04 year: 2020 text: 2020-04-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell host & microbe |
| PublicationTitleAlternate | Cell Host Microbe |
| PublicationYear | 2020 |
| SSID | ssj0055071 |
| Score | 2.5498574 |
| Snippet | Plants deploy a variety of secondary metabolites to fend off pathogen attack. Although defense compounds are generally considered toxic to microbes, the exact... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 601 |
| SubjectTerms | Arabidopsis - metabolism Bacterial Proteins - drug effects Cysteine - drug effects Cysteine - metabolism Disease Resistance Gene Expression Regulation, Bacterial Isothiocyanates - metabolism Isothiocyanates - pharmacology Plant Diseases - microbiology Pseudomonas syringae - drug effects Pseudomonas syringae - metabolism Secondary Metabolism Transcription Factors - drug effects Type III Secretion Systems - drug effects Type III Secretion Systems - genetics |
| Title | An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32272078 https://www.proquest.com/docview/2388820824 |
| Volume | 27 |
| WOSCitedRecordID | wos000525735600015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JS8NAFB7UKnhxX-rGCF6DzWSZzEmqtBiwpWAtvYVkFgxIEptU7E_wX_smk6oXQfAyh2SSDDMv731vR-jK5ZLH1CYW8RMCCkoirJhIYIbayM9tyf26nc_kgQ6HwXTKRo3BrWzCKpc8sWbUIufaRn4NogXAIAgs96Z4tXTXKO1dbVporKKWA1BGh3TR6ZcXQZfqso1X2bUAqLMmacbEd-leJKAfko4pcur-DjFrUdPf_u8id9BWAzJx11DFLlqR2R7aMG0nF_voo5vBvThJRV6UaYkftVIs4tkCD2QFRKHTkrHhhS8LPK5jxUvce29iZjOcKwy4Ed-aSs_wJa3N4jAM9at0WiTMMaXQcZXjMHtOk7T6MX2SzuZ1stMBeur3xnf3VtOSweIg7SrLDjhT3JGUA660Pel7XDDpCtBLOtxxlO24ymYi8DjABAFXgGNQpSQBWEK4x8ghWsvyTB4jLGmgKIuVL6jSdchiBdoLIYIJKRIY2-hyuccRkLz2Y8SZzOdl9L3LbXRkDioqTG2OCPgTJQB7Tv7w9Cna1Odfx-EEZ6il4IeX52idv1VpObuoaQnG4WjwCWh-1To |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+Arabidopsis+Secondary+Metabolite+Directly+Targets+Expression+of+the+Bacterial+Type+III+Secretion+System+to+Inhibit+Bacterial+Virulence&rft.jtitle=Cell+host+%26+microbe&rft.au=Wang%2C+Wei&rft.au=Yang%2C+Jing&rft.au=Zhang%2C+Jian&rft.au=Liu%2C+Yong-Xin&rft.date=2020-04-08&rft.issn=1934-6069&rft.eissn=1934-6069&rft.volume=27&rft.issue=4&rft.spage=601&rft_id=info:doi/10.1016%2Fj.chom.2020.03.004&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1934-6069&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1934-6069&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1934-6069&client=summon |