Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression

One of the major limitations to current gene therapy is the low-level and transient vector gene expression due to poorly defined mechanisms, possibly including promoter attenuation or extinction. Because the application of gene therapy vectors in vivo induces cytokine production through specific or...

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Bibliographic Details
Published in:	Human gene therapy Vol. 8; no. 17; p. 2019
Main Authors:	Qin, L, Ding, Y, Pahud, D R, Chang, E, Imperiale, M J, Bromberg, J S
Format:	Journal Article
Language:	English
Published:	United States 20.11.1997
Subjects:	Adenoviruses, Human - genetics Animals Antibodies, Monoclonal - immunology Avian Sarcoma Viruses - genetics Cell Line Cytomegalovirus - genetics DNA, Viral - drug effects Drug Synergism Gene Expression Regulation - drug effects Genes, Reporter Genetic Therapy Genetic Vectors - drug effects Genetic Vectors - immunology Humans Interferon-gamma - immunology Interferon-gamma - pharmacology Lac Operon Mice Mice, Inbred C57BL Moloney murine leukemia virus - genetics Plasmids Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - immunology RNA, Messenger Simian virus 40 - genetics Transformation, Genetic Transgenes - drug effects Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - pharmacology
ISSN:	1043-0342
Online Access:	Get more information
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