Hierarchical and symmetric infant image registration by robust longitudinal‐example‐guided correspondence detection
Purpose: To investigate anatomical differences across individual subjects, or longitudinal changes in early brain development, it is important to perform accurate image registration. However, due to fast brain development and dynamic tissue appearance changes, it is very difficult to align infant br...
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| Published in: | Medical physics (Lancaster) Vol. 42; no. 7; pp. 4174 - 4189 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
American Association of Physicists in Medicine
01.07.2015
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| Subjects: | |
| ISSN: | 0094-2405, 2473-4209, 2473-4209 |
| Online Access: | Get full text |
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| Summary: | Purpose:
To investigate anatomical differences across individual subjects, or longitudinal changes in early brain development, it is important to perform accurate image registration. However, due to fast brain development and dynamic tissue appearance changes, it is very difficult to align infant brain images acquired from birth to 1‐yr‐old.
Methods:
To solve this challenging problem, a novel image registration method is proposed to align two infant brain images, regardless of age at acquisition. The main idea is to utilize the growth trajectories, or spatial‐temporal correspondences, learned from a set of longitudinal training images, for guiding the registration of two different time‐point images with different image appearances. Specifically, in the training stage, an intrinsic growth trajectory is first estimated for each training subject using the longitudinal images. To register two new infant images with potentially a large age gap, the corresponding images patches between each new image and its respective training images with similar age are identified. Finally, the registration between the two new images can be assisted by the learned growth trajectories from one time point to another time point that have been established in the training stage. To further improve registration accuracy, the proposed method is combined with a hierarchical and symmetric registration framework that can iteratively add new key points in both images to steer the estimation of the deformation between the two infant brain images under registration.
Results:
To evaluate image registration accuracy, the proposed method is used to align 24 infant subjects at five different time points (2‐week‐old, 3‐month‐old, 6‐month‐old, 9‐month‐old, and 12‐month‐old). Compared to the state‐of‐the‐art methods, the proposed method demonstrated superior registration performance.
Conclusions:
The proposed method addresses the difficulties in the infant brain registration and produces better results compared to existing state‐of‐the‐art registration methods. |
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| Bibliography: | bmunsell@cofc.edu yaowu1588@gmail.com qianjinfeng08@gmail.com dgshen@med.unc.edu weili_lin@med.unc.edu , wang.qian@sjtu.edu.cn grwu@med.unc.edu and li_wang@med.unc.edu wufanchen@gmail.com Authors to whom correspondence should be addressed. Electronic addresses Electronic addresses ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 Electronic addresses: yaowu1588@gmail.com, grwu@med.unc.edu, li_wang@med.unc.edu, bmunsell@cofc.edu, wang.qian@sjtu.edu.cn, weili_lin@med.unc.edu, and wufanchen@gmail.com Authors to whom correspondence should be addressed. Electronic addresses: qianjinfeng08@gmail.com and dgshen@med.unc.edu |
| ISSN: | 0094-2405 2473-4209 2473-4209 |
| DOI: | 10.1118/1.4922393 |