Circulating microRNAs in Medicine

Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Stu...

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Vydáno v:	International journal of molecular sciences Ročník 23; číslo 7; s. 3996
Hlavní autoři:	Pozniak, Tetiana, Shcharbin, Dzmitry, Bryszewska, Maria
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 03.04.2022 MDPI
Témata:	Apoptosis Biomarkers Cancer Cardiovascular Diseases Cell cycle Circulating MicroRNA Cloning DNA methylation Enzymes Gene expression Genomes Humans Insects Medicine MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Mutation Physiology Protein synthesis Proteins Review small interfering RNAs (miRNAs) neurodegenerative diseases cardiovascular diseases oncology circulating microRNAs (c-microRNAs, c-miRNAs)
ISSN:	1422-0067, 1661-6596, 1422-0067
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Abstract	Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient’s response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes.
AbstractList	Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient's response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes. Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient's response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes.Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient's response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes.
Author	Bryszewska, Maria Pozniak, Tetiana Shcharbin, Dzmitry
AuthorAffiliation	1 Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, 220072 Minsk, Belarus 3 Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland; maria.bryszewska@biol.uni.lodz.pl 2 Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 02000 Kyiv, Ukraine
AuthorAffiliation_xml	– name: 2 Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 02000 Kyiv, Ukraine – name: 3 Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland; maria.bryszewska@biol.uni.lodz.pl – name: 1 Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Author_xml	– sequence: 1 givenname: Tetiana surname: Pozniak fullname: Pozniak, Tetiana – sequence: 2 givenname: Dzmitry orcidid: 0000-0002-1414-4465 surname: Shcharbin fullname: Shcharbin, Dzmitry – sequence: 3 givenname: Maria orcidid: 0000-0003-4676-3743 surname: Bryszewska fullname: Bryszewska, Maria
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35409354$$D View this record in MEDLINE/PubMed
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Keywords	small interfering RNAs (miRNAs) neurodegenerative diseases cardiovascular diseases oncology circulating microRNAs (c-microRNAs, c-miRNAs)
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Snippet	Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases...
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SubjectTerms	Apoptosis Biomarkers Cancer Cardiovascular Diseases Cell cycle Circulating MicroRNA Cloning DNA methylation Enzymes Gene expression Genomes Humans Insects Medicine MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Mutation Physiology Protein synthesis Proteins Review
Title	Circulating microRNAs in Medicine
URI	https://www.ncbi.nlm.nih.gov/pubmed/35409354 https://www.proquest.com/docview/2649056803 https://www.proquest.com/docview/2649588390 https://pubmed.ncbi.nlm.nih.gov/PMC8999557
Volume	23
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