Circulating microRNAs in Medicine

Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Stu...

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Vydáno v:International journal of molecular sciences Ročník 23; číslo 7; s. 3996
Hlavní autoři: Pozniak, Tetiana, Shcharbin, Dzmitry, Bryszewska, Maria
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 03.04.2022
MDPI
Témata:
Apoptosis
Biomarkers
Cancer
Cardiovascular Diseases
Cell cycle
Circulating MicroRNA
Cloning
DNA methylation
Enzymes
Gene expression
Genomes
Humans
Insects
Medicine
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Mutation
Physiology
Protein synthesis
Proteins
Review
small interfering RNAs (miRNAs)
neurodegenerative diseases
cardiovascular diseases
oncology
circulating microRNAs (c-microRNAs, c-miRNAs)
ISSN:1422-0067, 1661-6596, 1422-0067
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Popis
Shrnutí:Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient’s response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23073996