Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients

Abstract Twenty-five B-cell–depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) re...

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Vydáno v:Clinical infectious diseases Ročník 74; číslo 7; s. 1271 - 1274
Hlavní autoři: Gharbharan, Arvind, GeurtsvanKessel, Corine H, Jordans, Carlijn C E, Blaauw, Marc, van der Klift, Marjolein, Hassing, Robert-Jan, Smits-Zwinkels, Marijn, Meertens, Maaike, van den Hout, Ella C, de Man, Anne Marie, Hageman, Ilse, Bogers, Susanne, van der Schoot, C Ellen, Swaneveld, Francis, Anas, Adam A, Rokx, Casper, Rijnders, Bart J A
Médium: Journal Article
Jazyk:angličtina
Vydáno: US Oxford University Press 09.04.2022
Témata:
Antibodies, Neutralizing - therapeutic use
Antibodies, Viral
COVID-19 - therapy
Humans
Immunization, Passive
SARS-CoV-2
COVID
cell depletion
2
B
19
SARS
immunodeficiency
CoV
convalescent plasma
ISSN:1058-4838, 1537-6591, 1537-6591
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Shrnutí:Abstract Twenty-five B-cell–depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population.
Bibliografie:ObjectType-Article-1
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ObjectType-Feature-2
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ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciab647