Therapeutic Effect of Iron Citrate in Blocking Calcium Deposition in High Pi-Calcified VSMC: Role of Autophagy and Apoptosis

In chronic kidney disease (CKD), the first cause of mortality is cardiovascular disease induced mainly by vascular calcification (VC). Recently, iron-based phosphate binders have been proposed in advanced CKD to treat hyperphosphatemia. We studied the effect of iron citrate (iron) on the progression...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 20; no. 23; p. 5925
Main Authors:	Ciceri, Paola, Falleni, Monica, Tosi, Delfina, Martinelli, Carla, Cannizzo, Stefania, Marchetti, Giulia, D’Arminio Monforte, Antonella, Bulfamante, Gaetano, Block, Geoffrey A, Messa, Piergiorgio, Cozzolino, Mario
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25.11.2019 MDPI
Subjects:	Animals Apoptosis Apoptosis - drug effects Autophagy Calcification Calcium - toxicity Cells, Cultured Ferric Compounds - pharmacology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Phosphates - toxicity Proteins Rats Vascular Calcification - chemically induced Vascular Calcification - drug therapy Vascular Calcification - pathology phosphate apoptosis iron autophagy VSMC vascular calcification
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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