Single-molecule states link transcription factor binding to gene expression

The binding of multiple transcription factors (TFs) to genomic enhancers drives gene expression in mammalian cells 1 . However, the molecular details that link enhancer sequence to TF binding, promoter state and transcription levels remain unclear. Here we applied single-molecule footprinting 2 , 3...

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Vydáno v:	Nature (London) Ročník 636; číslo 8043; s. 745 - 754
Hlavní autoři:	Doughty, Benjamin R., Hinks, Michaela M., Schaepe, Julia M., Marinov, Georgi K., Thurm, Abby R., Rios-Martinez, Carolina, Parks, Benjamin E., Tan, Yingxuan, Marklund, Emil, Dubocanin, Danilo, Bintu, Lacramioara, Greenleaf, William J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 19.12.2024 Nature Publishing Group
Témata:	13 13/106 38 45/15 45/23 45/91 631/208/200 631/337/100 631/337/572 631/553/552 Binding Sites Chromatin DNA - genetics DNA - metabolism DNA Footprinting DNA Methylation Enhancer Elements, Genetic Enhancers Gene expression Gene Expression Regulation Humanities and Social Sciences Humans Interferon Type I - metabolism K562 Cells Kinetics Mammalian cells Models, Molecular multidisciplinary Nucleosomes Nucleosomes - genetics Nucleosomes - metabolism Nucleotide sequence Promoter Regions, Genetic Protein Binding Proteins Regulatory proteins Regulatory sequences Response Elements RNA polymerase Science Science (multidisciplinary) Single Molecule Imaging Statistical mechanics Thermodynamics Transcription factors Transcription Factors - metabolism
ISSN:	0028-0836, 1476-4687, 1476-4687
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