The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment

Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis and treatment because of their special fundamental properties. In order to make AuNPs more suitable for tumor diagnosis and treatment, their natural properties and the interrelationships between these pro...

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Vydáno v:International journal of molecular sciences Ročník 21; číslo 7; s. 2480
Hlavní autoři: Bai, Xue, Wang, Yueying, Song, Zhiyun, Feng, Yanmin, Chen, Yuanyuan, Zhang, Deyuan, Feng, Lin
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 03.04.2020
MDPI
Témata:
Biomarkers
Cancer therapies
Chemical Phenomena
Drug Delivery Systems
Early Detection of Cancer
Energy
Gold
Gold - administration & dosage
Gold - chemistry
Humans
Ligands
Light
Medical diagnosis
Metabolism
Metal Nanoparticles - chemistry
Nanoparticles
Neoplasms - diagnosis
Neoplasms - therapy
Optical properties
Physical properties
Physicochemical properties
Radiation therapy
Review
Spectrum analysis
Tumors
cancer nanotechnology
tumor diagnosis and treatment
drug delivery
gold nanoparticle
ISSN:1422-0067, 1661-6596, 1422-0067
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Shrnutí:Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis and treatment because of their special fundamental properties. In order to make AuNPs more suitable for tumor diagnosis and treatment, their natural properties and the interrelationships between these properties should be systematically and profoundly understood. The natural properties of AuNPs were discussed from two aspects: physical and chemical. Among the physical properties of AuNPs, localized surface plasmon resonance (LSPR), radioactivity and high X-ray absorption coefficient are widely used in the diagnosis and treatment of tumors. As an advantage over many other nanoparticles in chemicals, AuNPs can form stable chemical bonds with S-and N-containing groups. This allows AuNPs to attach to a wide variety of organic ligands or polymers with a specific function. These surface modifications endow AuNPs with outstanding biocompatibility, targeting and drug delivery capabilities. In this review, we systematically summarized the physicochemical properties of AuNPs and their intrinsic relationships. Then the latest research advancements and the developments of basic research and clinical trials using these properties are summarized. Further, the difficulties to be overcome and possible solutions in the process from basic laboratory research to clinical application are discussed. Finally, the possibility of applying the results to clinical trials was estimated. We hope to provide a reference for peer researchers to better utilize the excellent physicochemical properties of gold nanoparticles in oncotherapy.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21072480