SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P

SREBP transcription factors are central regulators of lipid metabolism. Their proteolytic activation requires ER to the Golgi translocation and subsequent cleavage by site-1-protease (S1P). Produced as a proprotein, S1P undergoes autocatalytic cleavage from its precursor S1P to mature S1P form. Here...

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Bibliographic Details
Published in:	Molecular and cellular biology Vol. 44; no. 4; pp. 123 - 137
Main Authors:	Hendrix, Sebastian, Tan, Josephine M. E., Ndoj, Klevis, Kingma, Jenina, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Kober, Daniel L., Zelcer, Noam
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 2024
Subjects:	Animals Cell Biology Endoplasmic Reticulum - metabolism Golgi Apparatus - metabolism HEK293 Cells Humans Liver - metabolism Mice Mice, Knockout Proprotein Convertases - genetics Proprotein Convertases - metabolism Proteolysis Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction Sterol Regulatory Element Binding Proteins - genetics Sterol Regulatory Element Binding Proteins - metabolism SPRING S1P SREBP proteolytic enzyme C12ORF49 cholesterol regulation post-transcriptional regulation lipid metabolism Cholesterol metabolism proteolysis
ISSN:	1098-5549, 0270-7306, 1098-5549
Online Access:	Get full text
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