Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production

Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity whe...

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Vydané v:	International journal of molecular sciences Ročník 21; číslo 22; s. 8772
Hlavní autori:	Osae, Eugene A., Bullock, Tiffany, Chintapalati, Madhavi, Brodesser, Susanne, Hanlon, Samuel, Redfern, Rachel, Steven, Philipp, Smith, C. Wayne, Rumbaut, Rolando E., Burns, Alan R.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 20.11.2020 MDPI
Predmet:	Adipose Tissue - chemistry Adipose Tissue - metabolism Animals Ceramides - classification Ceramides - isolation & purification Ceramides - metabolism Cholesterol Esters - classification Cholesterol Esters - isolation & purification Cholesterol Esters - metabolism Diet, High-Fat - adverse effects Dyslipidemias - etiology Dyslipidemias - metabolism Dyslipidemias - pathology Epididymis - chemistry Epididymis - metabolism Fasting Fatty acids Humans Hypertrophy - etiology Hypertrophy - metabolism Hypertrophy - pathology Lipids Male Mass spectrometry Meibomian Glands - metabolism Meibomian Glands - pathology Metabolic disorders Mice Mice, Inbred C57BL Mice, Obese Obesity Obesity - etiology Obesity - metabolism Obesity - pathology Plasma Principal Component Analysis Scientific imaging Sphingomyelins - classification Sphingomyelins - isolation & purification Sphingomyelins - metabolism Tears - chemistry Tears - metabolism Triglycerides Triglycerides - classification Triglycerides - isolation & purification Triglycerides - metabolism lipids meibomian gland dysfunction mass spectrometry meibum dry eye dyslipidemia obesity
ISSN:	1422-0067, 1661-6596, 1422-0067
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