Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production

Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity whe...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 21; no. 22; p. 8772
Main Authors:	Osae, Eugene A., Bullock, Tiffany, Chintapalati, Madhavi, Brodesser, Susanne, Hanlon, Samuel, Redfern, Rachel, Steven, Philipp, Smith, C. Wayne, Rumbaut, Rolando E., Burns, Alan R.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20.11.2020 MDPI
Subjects:	Adipose Tissue - chemistry Adipose Tissue - metabolism Animals Ceramides - classification Ceramides - isolation & purification Ceramides - metabolism Cholesterol Esters - classification Cholesterol Esters - isolation & purification Cholesterol Esters - metabolism Diet, High-Fat - adverse effects Dyslipidemias - etiology Dyslipidemias - metabolism Dyslipidemias - pathology Epididymis - chemistry Epididymis - metabolism Fasting Fatty acids Humans Hypertrophy - etiology Hypertrophy - metabolism Hypertrophy - pathology Lipids Male Mass spectrometry Meibomian Glands - metabolism Meibomian Glands - pathology Metabolic disorders Mice Mice, Inbred C57BL Mice, Obese Obesity Obesity - etiology Obesity - metabolism Obesity - pathology Plasma Principal Component Analysis Scientific imaging Sphingomyelins - classification Sphingomyelins - isolation & purification Sphingomyelins - metabolism Tears - chemistry Tears - metabolism Triglycerides Triglycerides - classification Triglycerides - isolation & purification Triglycerides - metabolism lipids meibomian gland dysfunction mass spectrometry meibum dry eye dyslipidemia obesity
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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