Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production

Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity whe...

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Vydané v:International journal of molecular sciences Ročník 21; číslo 22; s. 8772
Hlavní autori: Osae, Eugene A., Bullock, Tiffany, Chintapalati, Madhavi, Brodesser, Susanne, Hanlon, Samuel, Redfern, Rachel, Steven, Philipp, Smith, C. Wayne, Rumbaut, Rolando E., Burns, Alan R.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 20.11.2020
MDPI
Predmet:
Adipose Tissue - chemistry
Adipose Tissue - metabolism
Animals
Ceramides - classification
Ceramides - isolation & purification
Ceramides - metabolism
Cholesterol Esters - classification
Cholesterol Esters - isolation & purification
Cholesterol Esters - metabolism
Diet, High-Fat - adverse effects
Dyslipidemias - etiology
Dyslipidemias - metabolism
Dyslipidemias - pathology
Epididymis - chemistry
Epididymis - metabolism
Fasting
Fatty acids
Humans
Hypertrophy - etiology
Hypertrophy - metabolism
Hypertrophy - pathology
Lipids
Male
Mass spectrometry
Meibomian Glands - metabolism
Meibomian Glands - pathology
Metabolic disorders
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
Obesity - etiology
Obesity - metabolism
Obesity - pathology
Plasma
Principal Component Analysis
Scientific imaging
Sphingomyelins - classification
Sphingomyelins - isolation & purification
Sphingomyelins - metabolism
Tears - chemistry
Tears - metabolism
Triglycerides
Triglycerides - classification
Triglycerides - isolation & purification
Triglycerides - metabolism
lipids
meibomian gland dysfunction
mass spectrometry
meibum
dry eye
dyslipidemia
obesity
ISSN:1422-0067, 1661-6596, 1422-0067
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Abstract Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia. Methods: Male C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. Tear production was measured and meibography was performed. Body and epididymal adipose tissue (eAT) weights were determined. Nano-ESI-MS/MS and LC-ESI-MS/MS were used to detect CE, TG, Cer and SM species. Data were analyzed by principal component analysis, Pearson’s correlation and unpaired t-tests adjusted for multiple comparisons; significance set at p ≤ 0.05. Results: Compared to ND mice, HFD mice gained more weight and showed heavier eAT and dyslipidemia with higher levels of plasma CE, TG, Cer and SM. HFD mice had hypertrophic meibomian glands, increased levels of lipid species acylated by saturated fatty acids in plasma and meibum and excessive tear production. Conclusions: The majority of meibum lipid species with saturated fatty acids increased with HFD feeding with evidence of meibomian gland hypertrophy and excessive tearing. The dyslipidemia is associated with altered meibum composition, a key feature of MGD.
AbstractList Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia. Methods: Male C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. Tear production was measured and meibography was performed. Body and epididymal adipose tissue (eAT) weights were determined. Nano-ESI-MS/MS and LC-ESI-MS/MS were used to detect CE, TG, Cer and SM species. Data were analyzed by principal component analysis, Pearson’s correlation and unpaired t-tests adjusted for multiple comparisons; significance set at p ≤ 0.05. Results: Compared to ND mice, HFD mice gained more weight and showed heavier eAT and dyslipidemia with higher levels of plasma CE, TG, Cer and SM. HFD mice had hypertrophic meibomian glands, increased levels of lipid species acylated by saturated fatty acids in plasma and meibum and excessive tear production. Conclusions: The majority of meibum lipid species with saturated fatty acids increased with HFD feeding with evidence of meibomian gland hypertrophy and excessive tearing. The dyslipidemia is associated with altered meibum composition, a key feature of MGD.
Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia. Male C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. Tear production was measured and meibography was performed. Body and epididymal adipose tissue (eAT) weights were determined. Nano-ESI-MS/MS and LC-ESI-MS/MS were used to detect CE, TG, Cer and SM species. Data were analyzed by principal component analysis, Pearson's correlation and unpaired -tests adjusted for multiple comparisons; significance set at ≤ 0.05. Compared to ND mice, HFD mice gained more weight and showed heavier eAT and dyslipidemia with higher levels of plasma CE, TG, Cer and SM. HFD mice had hypertrophic meibomian glands, increased levels of lipid species acylated by saturated fatty acids in plasma and meibum and excessive tear production. The majority of meibum lipid species with saturated fatty acids increased with HFD feeding with evidence of meibomian gland hypertrophy and excessive tearing. The dyslipidemia is associated with altered meibum composition, a key feature of MGD.
Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia.BACKGROUNDDyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia.Male C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. Tear production was measured and meibography was performed. Body and epididymal adipose tissue (eAT) weights were determined. Nano-ESI-MS/MS and LC-ESI-MS/MS were used to detect CE, TG, Cer and SM species. Data were analyzed by principal component analysis, Pearson's correlation and unpaired t-tests adjusted for multiple comparisons; significance set at p ≤ 0.05.METHODSMale C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. Tear production was measured and meibography was performed. Body and epididymal adipose tissue (eAT) weights were determined. Nano-ESI-MS/MS and LC-ESI-MS/MS were used to detect CE, TG, Cer and SM species. Data were analyzed by principal component analysis, Pearson's correlation and unpaired t-tests adjusted for multiple comparisons; significance set at p ≤ 0.05.Compared to ND mice, HFD mice gained more weight and showed heavier eAT and dyslipidemia with higher levels of plasma CE, TG, Cer and SM. HFD mice had hypertrophic meibomian glands, increased levels of lipid species acylated by saturated fatty acids in plasma and meibum and excessive tear production.RESULTSCompared to ND mice, HFD mice gained more weight and showed heavier eAT and dyslipidemia with higher levels of plasma CE, TG, Cer and SM. HFD mice had hypertrophic meibomian glands, increased levels of lipid species acylated by saturated fatty acids in plasma and meibum and excessive tear production.The majority of meibum lipid species with saturated fatty acids increased with HFD feeding with evidence of meibomian gland hypertrophy and excessive tearing. The dyslipidemia is associated with altered meibum composition, a key feature of MGD.CONCLUSIONSThe majority of meibum lipid species with saturated fatty acids increased with HFD feeding with evidence of meibomian gland hypertrophy and excessive tearing. The dyslipidemia is associated with altered meibum composition, a key feature of MGD.
Author Brodesser, Susanne
Rumbaut, Rolando E.
Steven, Philipp
Chintapalati, Madhavi
Redfern, Rachel
Hanlon, Samuel
Burns, Alan R.
Bullock, Tiffany
Smith, C. Wayne
Osae, Eugene A.
AuthorAffiliation 1 College of Optometry, University of Houston, Houston, TX 77204, USA; sdhanlon@gmail.com (S.H.); rredfer2@central.uh.edu (R.R.); arburns2@central.uh.edu (A.R.B.)
5 Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
3 CECAD Research Center, Lipidomics/Metabolomics Facility, University of Cologne, 50931 Cologne, Germany; susanne.brodesser@uk-koeln.de
4 Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, 50937 Cologne, Germany; philipp.steven@uk-koeln.de
2 Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA; tbullock@bcm.edu (T.B.); chintala@bcm.edu (M.C.); cwsmith@bcm.edu (C.W.S.); rrumbaut@bcm.edu (R.E.R.)
AuthorAffiliation_xml – name: 3 CECAD Research Center, Lipidomics/Metabolomics Facility, University of Cologne, 50931 Cologne, Germany; susanne.brodesser@uk-koeln.de
– name: 5 Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
– name: 1 College of Optometry, University of Houston, Houston, TX 77204, USA; sdhanlon@gmail.com (S.H.); rredfer2@central.uh.edu (R.R.); arburns2@central.uh.edu (A.R.B.)
– name: 4 Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, 50937 Cologne, Germany; philipp.steven@uk-koeln.de
– name: 2 Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA; tbullock@bcm.edu (T.B.); chintala@bcm.edu (M.C.); cwsmith@bcm.edu (C.W.S.); rrumbaut@bcm.edu (R.E.R.)
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  surname: Burns
  fullname: Burns, Alan R.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33233559$$D View this record in MEDLINE/PubMed
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Keywords lipids
meibomian gland dysfunction
mass spectrometry
meibum
dry eye
dyslipidemia
obesity
Language English
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Snippet Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and...
Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 8772
SubjectTerms Adipose Tissue - chemistry
Adipose Tissue - metabolism
Animals
Ceramides - classification
Ceramides - isolation & purification
Ceramides - metabolism
Cholesterol Esters - classification
Cholesterol Esters - isolation & purification
Cholesterol Esters - metabolism
Diet, High-Fat - adverse effects
Dyslipidemias - etiology
Dyslipidemias - metabolism
Dyslipidemias - pathology
Epididymis - chemistry
Epididymis - metabolism
Fasting
Fatty acids
Humans
Hypertrophy - etiology
Hypertrophy - metabolism
Hypertrophy - pathology
Lipids
Male
Mass spectrometry
Meibomian Glands - metabolism
Meibomian Glands - pathology
Metabolic disorders
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
Obesity - etiology
Obesity - metabolism
Obesity - pathology
Plasma
Principal Component Analysis
Scientific imaging
Sphingomyelins - classification
Sphingomyelins - isolation & purification
Sphingomyelins - metabolism
Tears - chemistry
Tears - metabolism
Triglycerides
Triglycerides - classification
Triglycerides - isolation & purification
Triglycerides - metabolism
Title Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production
URI https://www.ncbi.nlm.nih.gov/pubmed/33233559
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https://pubmed.ncbi.nlm.nih.gov/PMC7699756
Volume 21
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