A Link between Genetic Disorders and Cellular Impairment, Using Human Induced Pluripotent Stem Cells to Reveal the Functional Consequences of Copy Number Variations in the Central Nervous System—A Close Look at Chromosome 15

Recent cutting-edge human genetics technology has allowed us to identify copy number variations (CNVs) and has provided new insights for understanding causative mechanisms of human diseases. A growing number of studies show that CNVs could be associated with physiological mechanisms linked to evolut...

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Veröffentlicht in:	International journal of molecular sciences Jg. 21; H. 5; S. 1860
Hauptverfasser:	Casamassa, Alessia, Ferrari, Daniela, Gelati, Maurizio, Carella, Massimo, Vescovi, Angelo Luigi, Rosati, Jessica
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 09.03.2020 MDPI
Schlagworte:	Animals Brain Cellular Reprogramming - genetics Central Nervous System - physiology Chromosomes Chromosomes, Human, Pair 15 - genetics DNA Copy Number Variations - genetics Genetic Diseases, Inborn - genetics Genetic disorders Genomic Instability - genetics Humans Induced Pluripotent Stem Cells - physiology Mutation Review neurodevelopmental diseases 15q iPSCs Copy Number Variation (CNV) induced pluripotent stem cells (iPSCs) 15q mice neuropsychiatric diseases
ISSN:	1422-0067, 1661-6596, 1422-0067
Online-Zugang:	Volltext
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