Long-Term Shaping of Corticostriatal Synaptic Activity by Acute Fasting

Food restriction is a robust nongenic, nonsurgical and nonpharmacologic intervention known to improve health and extend lifespan in various species. Food is considered the most essential and frequently consumed natural reward, and current observations have demonstrated homeostatic responses and neur...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 22; no. 4; p. 1916
Main Authors: Campanelli, Federica, Laricchiuta, Daniela, Natale, Giuseppina, Marino, Gioia, Calabrese, Valeria, Picconi, Barbara, Petrosini, Laura, Calabresi, Paolo, Ghiglieri, Veronica
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 15.02.2021
MDPI
Subjects:
Animal cognition
Animals
Corpus Striatum - metabolism
Diet Therapy
Dopamine - metabolism
Fasting
Fasting - physiology
Food
Food Deprivation - physiology
Glutamic Acid - metabolism
Male
Mice
Mice, Inbred C57BL
Neuronal Plasticity - physiology
Neurons - metabolism
Protocol
Receptors, AMPA - metabolism
Synapses
Synapses - metabolism
Synaptic Transmission - physiology
dorsolateral striatum
GluA1
dietary restriction
calcium-permeable AMPA
naphthyl-acetyl spermine
food deprivation
ISSN:1422-0067, 1661-6596, 1422-0067
Online Access:Get full text
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Summary:Food restriction is a robust nongenic, nonsurgical and nonpharmacologic intervention known to improve health and extend lifespan in various species. Food is considered the most essential and frequently consumed natural reward, and current observations have demonstrated homeostatic responses and neuroadaptations to sustained intermittent or chronic deprivation. Results obtained to date indicate that food deprivation affects glutamatergic synapses, favoring the insertion of GluA2-lacking α-Ammino-3-idrossi-5-Metil-4-idrossazol-Propionic Acid receptors (AMPARs) in postsynaptic membranes. Despite an increasing number of studies pointing towards specific changes in response to dietary restrictions in brain regions, such as the nucleus accumbens and hippocampus, none have investigated the long-term effects of such practice in the dorsal striatum. This basal ganglia nucleus is involved in habit formation and in eating behavior, especially that based on dopaminergic control of motivation for food in both humans and animals. Here, we explored whether we could retrieve long-term signs of changes in AMPARs subunit composition in dorsal striatal neurons of mice acutely deprived for 12 hours/day for two consecutive days by analyzing glutamatergic neurotransmission and the principal forms of dopamine and glutamate-dependent synaptic plasticity. Overall, our data show that a moderate food deprivation in experimental animals is a salient event mirrored by a series of neuroadaptations and suggest that dietary restriction may be determinant in shaping striatal synaptic plasticity in the physiological state.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22041916