Amyloid and Light Chain Deposition Disorders

Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheob...

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Published in:Clinics in chest medicine Vol. 46; no. 4; p. 711
Main Authors: Baqir, Misbah, Moua, Teng, Ryu, Jay H
Format: Journal Article
Language:English
Published: United States 01.12.2025
Subjects:
Amyloidosis - diagnosis
Amyloidosis - therapy
Humans
Immunoglobulin Light Chains - metabolism
Immunoglobulin Light-chain Amyloidosis - diagnosis
Lung Diseases - diagnosis
Serum Amyloid A Protein - metabolism
AL amyloidosis
Nodular pulmonary amyloidosis
Light chain deposition disease (LCDD)
Cystic pulmonary amyloidosis
Pulmonary manifestations
Diffuse alveolar-septal amyloidosis
AA amyloidosis
ATTR amyloidosis
ISSN:1557-8216, 1557-8216
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Abstract Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheobronchial involvement. The types of amyloidosis-immunoglobulin light chain), serum amyloid A, and transthyretin (ATTR)-affect the lungs differently, with ATTR being rare. LCDD, which primarily affects the kidneys, may also cause lung abnormalities, such as cystic or nodular disease. Both conditions are diagnosed through biopsy and imaging, with therapies targeting the underlying plasma cell or inflammatory disorders.
AbstractList Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheobronchial involvement. The types of amyloidosis-immunoglobulin light chain), serum amyloid A, and transthyretin (ATTR)-affect the lungs differently, with ATTR being rare. LCDD, which primarily affects the kidneys, may also cause lung abnormalities, such as cystic or nodular disease. Both conditions are diagnosed through biopsy and imaging, with therapies targeting the underlying plasma cell or inflammatory disorders.Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheobronchial involvement. The types of amyloidosis-immunoglobulin light chain), serum amyloid A, and transthyretin (ATTR)-affect the lungs differently, with ATTR being rare. LCDD, which primarily affects the kidneys, may also cause lung abnormalities, such as cystic or nodular disease. Both conditions are diagnosed through biopsy and imaging, with therapies targeting the underlying plasma cell or inflammatory disorders.
Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheobronchial involvement. The types of amyloidosis-immunoglobulin light chain), serum amyloid A, and transthyretin (ATTR)-affect the lungs differently, with ATTR being rare. LCDD, which primarily affects the kidneys, may also cause lung abnormalities, such as cystic or nodular disease. Both conditions are diagnosed through biopsy and imaging, with therapies targeting the underlying plasma cell or inflammatory disorders.
Author Baqir, Misbah
Moua, Teng
Ryu, Jay H
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  organization: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, Minnesota 55905, USA. Electronic address: baqir.misbah@mayo.edu
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  givenname: Jay H
  surname: Ryu
  fullname: Ryu, Jay H
  organization: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, Minnesota 55905, USA
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Keywords AL amyloidosis
Nodular pulmonary amyloidosis
Light chain deposition disease (LCDD)
Cystic pulmonary amyloidosis
Pulmonary manifestations
Diffuse alveolar-septal amyloidosis
AA amyloidosis
ATTR amyloidosis
Language English
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SubjectTerms Amyloidosis - diagnosis
Amyloidosis - therapy
Humans
Immunoglobulin Light Chains - metabolism
Immunoglobulin Light-chain Amyloidosis - diagnosis
Lung Diseases - diagnosis
Serum Amyloid A Protein - metabolism
Title Amyloid and Light Chain Deposition Disorders
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