Amyloid and Light Chain Deposition Disorders

Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheob...

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Vydáno v:Clinics in chest medicine Ročník 46; číslo 4; s. 711
Hlavní autoři: Baqir, Misbah, Moua, Teng, Ryu, Jay H
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.12.2025
Témata:
Amyloidosis - diagnosis
Amyloidosis - therapy
Humans
Immunoglobulin Light Chains - metabolism
Immunoglobulin Light-chain Amyloidosis - diagnosis
Lung Diseases - diagnosis
Serum Amyloid A Protein - metabolism
AL amyloidosis
Nodular pulmonary amyloidosis
Light chain deposition disease (LCDD)
Cystic pulmonary amyloidosis
Pulmonary manifestations
Diffuse alveolar-septal amyloidosis
AA amyloidosis
ATTR amyloidosis
ISSN:1557-8216, 1557-8216
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Shrnutí:Amyloidosis and Light Chain Deposition Disease (LCDD) are disorders characterized by the deposition of abnormal proteins in tissues, leading to organ damage. Pulmonary involvement in amyloidosis can manifest as diffuse alveolar-septal amyloidosis, nodular or cystic pulmonary amyloidosis, or tracheobronchial involvement. The types of amyloidosis-immunoglobulin light chain), serum amyloid A, and transthyretin (ATTR)-affect the lungs differently, with ATTR being rare. LCDD, which primarily affects the kidneys, may also cause lung abnormalities, such as cystic or nodular disease. Both conditions are diagnosed through biopsy and imaging, with therapies targeting the underlying plasma cell or inflammatory disorders.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1557-8216
1557-8216
DOI:10.1016/j.ccm.2025.07.010