Detection of Antigen-Specific T Cells Using In Situ MHC Tetramer Staining

The development of in situ major histocompatibility complex (MHC) tetramer (IST) staining to detect antigen (Ag)-specific T cells in tissues has radically revolutionized our knowledge of the local cellular immune response to viral and bacterial infections, cancers, and autoimmunity. IST combined wit...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 20; no. 20; p. 5165
Main Authors:	Abdelaal, Hadia M., Cartwright, Emily K., Skinner, Pamela J.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 18.10.2019 MDPI
Subjects:	Antibodies Antigens Epitopes, T-Lymphocyte - immunology Flow cytometry Humans Immune response Immunohistochemistry Lymphocytes Major Histocompatibility Complex Peptides Protein Multimerization Review Sensitivity and Specificity Spleen Staining and Labeling T cell receptors T-Cell Antigen Receptor Specificity T-Lymphocytes - immunology T-Lymphocytes - metabolism Transgenic animals antigen-specific confocal microscopy immune response MHC tetramer T cells In situ tetramer staining fresh tissue
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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