Moxifloxacin Pharmacokinetics, Cardiac Safety, and Dosing for the Treatment of Rifampicin-Resistant Tuberculosis in Children

Moxifloxacin is a recommended drug for rifampin-resistant tuberculosis (RR-TB) treatment, but there is limited pediatric pharmacokinetic and safety data, especially in young children. We characterize moxifloxacin population pharmacokinetics and QT interval prolongation and evaluate optimal dosing in...

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Veröffentlicht in:	Clinical infectious diseases Jg. 74; H. 8; S. 1372
Hauptverfasser:	Radtke, Kendra K, Hesseling, Anneke C, Winckler, J L, Draper, Heather R, Solans, Belen P, Thee, Stephanie, Wiesner, Lubbe, van der Laan, Louvina E, Fourie, Barend, Nielsen, James, Schaaf, H Simon, Savic, Radojka M, Garcia-Prats, Anthony J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 28.04.2022
Schlagworte:	Adult Child Child, Preschool Electrocardiography Fluoroquinolones - adverse effects HIV Infections Humans Moxifloxacin - adverse effects Rifampin - adverse effects Rifampin - pharmacokinetics Tuberculosis - drug therapy Tuberculosis, Multidrug-Resistant - drug therapy pharmacokinetics pediatrics tuberculosis moxifloxacin
ISSN:	1537-6591, 1537-6591
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