Human Chorionic Gonadotropin and Breast Cancer

Breast cancer is well known as a malignancy being strongly influenced by female steroids. Pregnancy is a protective factor against breast cancer. Human chorionic gonadotropin (HCG) is a candidate hormone which could mediate this antitumoral effect of pregnancy. For this review article, all original...

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Veröffentlicht in:International journal of molecular sciences Jg. 18; H. 7; S. 1587
Hauptverfasser: Schüler-Toprak, Susanne, Treeck, Oliver, Ortmann, Olaf
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 21.07.2017
MDPI
Schlagworte:
Apoptosis
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Chorionic Gonadotropin - genetics
Chorionic Gonadotropin - metabolism
Chorionic Gonadotropin, beta Subunit, Human - genetics
Chorionic Gonadotropin, beta Subunit, Human - metabolism
Female
Genomic Imprinting
Health risk assessment
Hormone replacement therapy
Humans
Medical prognosis
Placenta - metabolism
Pregnancy
Review
Socioeconomic factors
human chorionic gonadotropin
breast cancer
pregnancy
ISSN:1422-0067, 1661-6596, 1422-0067
Online-Zugang:Volltext
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Zusammenfassung:Breast cancer is well known as a malignancy being strongly influenced by female steroids. Pregnancy is a protective factor against breast cancer. Human chorionic gonadotropin (HCG) is a candidate hormone which could mediate this antitumoral effect of pregnancy. For this review article, all original research articles on the role of HCG in breast cancer were considered, which are listed in PubMed database and were written in English. The role of HCG in breast cancer seems to be a paradox. Placental heterodimeric HCG acts as a protective agent by imprinting a permanent genomic signature of the mammary gland determining a refractory condition to malignant transformation which is characterized by cellular differentiation, apoptosis and growth inhibition. On the other hand, ectopic expression of β-HCG in various cancer entities is associated with poor prognosis due to its tumor-promoting function. Placental HCG and ectopically expressed β-HCG exert opposite effects on breast tumorigenesis. Therefore, mimicking pregnancy by treatment with HCG is suggested as a strategy for breast cancer prevention, whereas targeting β-HCG expressing tumor cells seems to be an option for breast cancer therapy.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18071587