RNA-Seq Provides Insights into VEGF-Induced Signaling in Human Retinal Microvascular Endothelial Cells: Implications in Retinopathy of Prematurity

The pathophysiology of retinopathy of prematurity (ROP) is postulated to first involve delayed intraretinal vascularization, followed by intravitreal neovascularization (IVNV). Although intravitreal agents that reduce the bioactivity of vascular endothelial growth factor (VEGF) are used to treat IVN...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 13; p. 7354
Main Authors:	Ramshekar, Aniket, Bretz, Colin A., Hartnett, M. Elizabeth
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.07.2022 MDPI
Subjects:	Angiogenesis Animals Datasets Disease Models, Animal Endothelial Cells - metabolism Gene expression Humans Hypotheses Infant, Newborn Neovascularization, Pathologic - metabolism Rats Rats, Sprague-Dawley Retinal Neovascularization - metabolism Retinal Vessels - metabolism Retinopathy of Prematurity - genetics Retinopathy of Prematurity - metabolism RNA-Seq Signal Transduction Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism VEGFR2 ROP RNA-seq HRMECs VEGF STAT3 KDR
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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