Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny

To understand how infection by (Mtb) is modulated by host cell phenotype, we characterized those host phagocytes that controlled or supported bacterial growth during early infection, focusing on the ontologically distinct alveolar macrophage (AM) and interstitial macrophage (IM) lineages. Using fluo...

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Vydáno v:	The Journal of experimental medicine Ročník 215; číslo 4; s. 1135
Hlavní autoři:	Huang, Lu, Nazarova, Evgeniya V, Tan, Shumin, Liu, Yancheng, Russell, David G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 02.04.2018
Témata:	Animals Bystander Effect Cell Cycle Cell Proliferation Cellular Reprogramming Fatty Acids - metabolism Genes, Reporter Glycolysis Host-Pathogen Interactions Macrophages, Alveolar - metabolism Macrophages, Alveolar - microbiology Macrophages, Alveolar - pathology Metabolic Networks and Pathways Mice, Inbred C57BL Models, Biological Monocytes - pathology Mycobacterium tuberculosis - growth & development Oxidation-Reduction Phagocytes - metabolism Transcription, Genetic Tuberculosis - microbiology Tuberculosis - pathology
ISSN:	1540-9538, 1540-9538
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