From the past, a long way to future challenges for a greater control of tuberculosis

Tuberculosis (TB) and humans have coexisted for more than 40,000 years; however TB remains a global threat to human kind. The international community has developed new tools for early detection, but TB strains evolved acquiring resistance to first-line therapeutic drugs with increasing treatment cha...

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Published in:Tuberculosis (Edinburgh, Scotland) Vol. 123; p. 101948
Main Authors: Villa, Simone, Riccardi, Niccolò, Canetti, Diana, Alagna, Riccardo, Castellotti, Paola, Ferrarese, Maurizio, Cirillo, Daniela, Barberis, Ilaria, Bragazzi, Nicola Luigi, Gazzaniga, Valentina, Ricucci, Valentina, Codecasa, Luigi Ruffo, Besozzi, Giorgio, Martini, Mariano
Format: Journal Article
Language:English
Published: London Elsevier Ltd 01.07.2020
Elsevier Science Ltd
Subjects:
Drug resistance
Drugs
End TB
Evolution of TB
Future challenges
HIV
Human immunodeficiency virus
Past
Quality of life
Social protection
Tuberculosis
Vaccines
Viruses
End TB
Tuberculosis
Future challenges
Evolution of TB
Past
ISSN:1472-9792, 1873-281X, 1873-281X
Online Access:Get full text
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Summary:Tuberculosis (TB) and humans have coexisted for more than 40,000 years; however TB remains a global threat to human kind. The international community has developed new tools for early detection, but TB strains evolved acquiring resistance to first-line therapeutic drugs with increasing treatment challenges. Furthermore, TB has formed also an alliance with human immunodeficiency virus; in this way the poorest populations are most affected. The current vaccine planning activity includes 14 new vaccines against TB (11 of those in the phaseII/III) developed with different techniques. Now, more than ever, new anti-TB drugs and new anti-TB regimens are urgently required as well as universal health care and social protection in order to tackle down both hard to treat TB and the social determinants of TB. Coordinated actions and sharing of information are needed to aspire everywhere to the best clinical practices and improve quality of life of patients and their families.
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ISSN:1472-9792
1873-281X
1873-281X
DOI:10.1016/j.tube.2020.101948