FastSKAT: Sequence kernel association tests for very large sets of markers

The sequence kernel association test (SKAT) is widely used to test for associations between a phenotype and a set of genetic variants that are usually rare. Evaluating tail probabilities or quantiles of the null distribution for SKAT requires computing the eigenvalues of a matrix related to the geno...

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Bibliographic Details
Published in:	Genetic epidemiology Vol. 42; no. 6; pp. 516 - 527
Main Authors:	Lumley, Thomas, Brody, Jennifer, Peloso, Gina, Morrison, Alanna, Rice, Kenneth
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.09.2018
Subjects:	Algorithms Chromosomes, Human - metabolism Computer applications convolution Eigenvalues genetic association Genetic Association Studies Genetic diversity Genetic Markers Genotypes Histones - metabolism Humans Lanczos algorithm Phenotypes randomized trace estimator Sequence Analysis, DNA Statistics as Topic stochastic singular value decomposition Time Factors genetic association Lanczos algorithm randomized trace estimator convolution stochastic singular value decomposition
ISSN:	0741-0395, 1098-2272, 1098-2272
Online Access:	Get full text
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