Self-Maintaining CD103 + Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses

Enrichment of CD103 tumor-infiltrating T lymphocytes (TIL) is associated with improved outcomes in patients. However, the characteristics of human CD103 cytotoxic CD8 T cells (CTL) and their role in tumor control remain unclear. We investigated the features and antitumor mechanisms of CD103 CTLs by...

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Veröffentlicht in:	Cancer immunology research Jg. 8; H. 2; S. 203
Hauptverfasser:	Abd Hamid, Megat, Colin-York, Huw, Khalid-Alham, Nasullah, Browne, Molly, Cerundolo, Lucia, Chen, Ji-Li, Yao, Xuan, Rosendo-Machado, Samara, Waugh, Craig, Maldonado-Perez, David, Bowes, Emma, Verrill, Clare, Cerundolo, Vincenzo, Conlon, Christopher P, Fritzsche, Marco, Peng, Yanchun, Dong, Tao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2020
Schlagworte:	Antigens, CD - immunology Antigens, CD - metabolism CD8-Positive T-Lymphocytes - immunology Humans Immunophenotyping - methods Integrin alpha Chains - immunology Integrin alpha Chains - metabolism Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphocytes, Tumor-Infiltrating - immunology Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Prognosis Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T-Lymphocytes, Cytotoxic - immunology Transforming Growth Factor beta1 - immunology Transforming Growth Factor beta1 - metabolism
ISSN:	2326-6074, 2326-6074
Online-Zugang:	Weitere Angaben
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