Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic population. Both experimental and clinical evidence suggest that diabetic subjects are predisposed to a distinct cardiomyopathy, independent of concomitant macro- and microvascular disorders. 'Diabetic car...

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Bibliographic Details
Published in:	Pharmacology & therapeutics (Oxford) Vol. 142; no. 3; pp. 375 - 415
Main Authors:	Huynh, Karina, Bernardo, Bianca C., McMullen, Julie R., Ritchie, Rebecca H.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 01.06.2014
Subjects:	Antioxidants - physiology Apoptosis Autophagy Biological and medical sciences Calcium - metabolism Cardiology. Vascular system Diabetes. Impaired glucose tolerance Diabetic Cardiomyopathies - drug therapy Diabetic Cardiomyopathies - physiopathology Diastole Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fibrosis Heart Hexosamines - biosynthesis Humans Medical sciences MicroRNAs - physiology Myocarditis. Cardiomyopathies Myocardium - pathology Reactive Oxygen Species - metabolism Signal Transduction - drug effects Endocrinopathy Heart Oxidative stress Reactive oxygen species Targeting Cardiomyopathy Cardiovascular disease Remodeling Myocardial disease Research and development Antioxidants Signal transduction Target Signaling pathway Heart disease Cardiac remodeling Mechanism of action Pl3K(p110α) Diabetes mellitus Antioxidant Treatment Dysfunction Diastolic dysfunction Circulatory system Diabetes PI3K(p110α)
ISSN:	0163-7258, 1879-016X, 1879-016X
Online Access:	Get full text
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