HFpEF etiology – Can focus on sex-specific mechanisms deliver insights for all?

[Display omitted] •HFpEF is highly prevalent in women, with a gender distribution ratio of 2:1.•The aging female demographic confers an increased burden of disease in women.•Women with HFpEF have markedly increased incidence of diastolic dysfunction.•Sex-specific molecular understanding of diastolic...

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Vydáno v:Journal of molecular and cellular cardiology Ročník 173; s. 71 - 72
Hlavní autoři: Delbridge, L.M.D., Bell, J.R., Weeks, K.L., Raaijmakers, A.J.A., Mellor, K.M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.12.2022
Témata:
Diastole
Diastolic function
Female
Heart Failure
Heart failure with preserved ejection fraction
Humans
Male
Sex differences
Stroke Volume
Ventricular Function, Left
Heart failure with preserved ejection fraction
Diastolic function
Sex differences
ISSN:0022-2828, 1095-8584, 1095-8584
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Shrnutí:[Display omitted] •HFpEF is highly prevalent in women, with a gender distribution ratio of 2:1.•The aging female demographic confers an increased burden of disease in women.•Women with HFpEF have markedly increased incidence of diastolic dysfunction.•Sex-specific molecular understanding of diastolic dysfunction in HFpEF is required.•Discerning the mechanisms of HFpEF sex disparity will help identify new treatments.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 23
ISSN:0022-2828
1095-8584
1095-8584
DOI:10.1016/j.yjmcc.2022.09.005