YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells

Recent studies show that YTH domain family 2 (YTHDF2) preferentially binds to m A-containing mRNA regulates localization and stability of the bound mRNA. However, the role of YTHDF2 in pancreatic cancers remains to be elucidated. Here, we find that YTHDF2 expression is up-regulated in pancreatic can...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 16; no. 23; pp. 2259 - 2271
Main Authors:	Chen, Jixiang, Sun, Yaocheng, Xu, Xiao, Wang, Dawei, He, Junbo, Zhou, Hailang, Lu, Ying, Zeng, Jian, Du, Fengyi, Gong, Aihua, Xu, Min
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.01.2017
Subjects:	Adaptor Proteins, Signal Transducing - metabolism Cell Line, Tumor Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition G1 Phase Cell Cycle Checkpoints Humans Neoplasm Staging Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphoproteins - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA Interference RNA, Small Interfering - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction Smad Proteins - metabolism Transcription Factors Transforming Growth Factor beta - metabolism Up-Regulation YAP pancreatic cancer YTHDF2 migration-proliferation dichotomy EMT
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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