A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain

FGFs and Wnts are important morphogens during midbrain development, but their importance and potential interactions during neurogenesis are poorly understood. We have employed a combination of genetic and pharmacological manipulations in zebrafish to show that during neurogenesis FGF activity occurs...

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Veröffentlicht in:	Development (Cambridge) Jg. 141; H. 1; S. 63
Hauptverfasser:	Dyer, Carlene, Blanc, Eric, Hanisch, Anja, Roehl, Henry, Otto, Georg W, Yu, Tian, Basson, M A, Knight, Robert
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.01.2014
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Movement Fibroblast Growth Factors - metabolism Gene Expression Regulation, Developmental Mesencephalon - embryology Mesencephalon - growth & development Mesencephalon - metabolism Mice Mice, Knockout Nerve Tissue Proteins - metabolism Neural Stem Cells - metabolism Neurogenesis Wnt Signaling Pathway - physiology Zebrafish Zebrafish Proteins - biosynthesis Zebrafish Proteins - metabolism Zebrafish Chemical genetics Mathematical modelling Hairy Neurogenesis Sprouty
ISSN:	1477-9129, 1477-9129
Online-Zugang:	Weitere Angaben
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