The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis
Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS). To assess the association between alcohol and red wine consumption and MS course. MS patients enrolled in the Comprehensive Longitud...
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| Veröffentlicht in: | Multiple sclerosis and related disorders Jg. 17; S. 47 - 53 |
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Elsevier B.V
01.10.2017
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| Abstract | Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS).
To assess the association between alcohol and red wine consumption and MS course.
MS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study. Alcohol and red wine consumption were measured as servings/week. The primary outcome was the Expanded Disability Status Scale (EDSS) at the time of the questionnaire. Secondary clinical outcomes were the Multiple Sclerosis Severity Score (MSSS) and number of relapses in the year before the questionnaire. Secondary MRI outcomes included brain parenchymal fraction and T2 hyperintense lesion volume (T2LV). Appropriate regression models were used to test the association of alcohol and red wine intake on clinical and MRI outcomes. All analyses were controlled for sex, age, body mass index, disease phenotype (relapsing vs. progressive), the proportion of time on disease modifying therapy during the previous year, smoking exposure, and disease duration. In the models for the MRI outcomes, analyses were also adjusted for acquisition protocol.
923 patients (74% females, mean age 47 ± 11 years, mean disease duration 14 ± 9 years) were included in the analysis. Compared to abstainers, patients drinking more than 4 drinks per week had a higher likelihood of a lower EDSS score (OR, 0.41; p = 0.0001) and lower MSSS (mean difference, − 1.753; p = 0.002) at the time of the questionnaire. Similarly, patients drinking more than 3 glasses of red wine per week had greater odds of a lower EDSS (OR, 0.49; p = 0.0005) and lower MSSS (mean difference, − 0.705; p = 0.0007) compared to nondrinkers. However, a faster increase in T2LV was observed in patients consuming 1–3 glasses of red wine per week compared to nondrinkers.
Higher total alcohol and red wine intake were associated with a lower cross-sectional level of neurologic disability in MS patients but increased T2LV accumulation. Further studies should explore a potential cause-effect neuroprotective relationship, as well as the underlying biological mechanisms.
•Moderate alcohol consumption was associated with lower EDSS score and MSSS.•Drinking > 3 glasses of red wine/week was associated with lower EDSS score and MSSS.•Subjects drinking 1–3 glasses of red wine/week had an increase in MRI lesion volume accumulation. |
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| AbstractList | Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS).
To assess the association between alcohol and red wine consumption and MS course.
MS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study. Alcohol and red wine consumption were measured as servings/week. The primary outcome was the Expanded Disability Status Scale (EDSS) at the time of the questionnaire. Secondary clinical outcomes were the Multiple Sclerosis Severity Score (MSSS) and number of relapses in the year before the questionnaire. Secondary MRI outcomes included brain parenchymal fraction and T2 hyperintense lesion volume (T2LV). Appropriate regression models were used to test the association of alcohol and red wine intake on clinical and MRI outcomes. All analyses were controlled for sex, age, body mass index, disease phenotype (relapsing vs. progressive), the proportion of time on disease modifying therapy during the previous year, smoking exposure, and disease duration. In the models for the MRI outcomes, analyses were also adjusted for acquisition protocol.
923 patients (74% females, mean age 47 ± 11 years, mean disease duration 14 ± 9 years) were included in the analysis. Compared to abstainers, patients drinking more than 4 drinks per week had a higher likelihood of a lower EDSS score (OR, 0.41; p = 0.0001) and lower MSSS (mean difference, - 1.753; p = 0.002) at the time of the questionnaire. Similarly, patients drinking more than 3 glasses of red wine per week had greater odds of a lower EDSS (OR, 0.49; p = 0.0005) and lower MSSS (mean difference, - 0.705; p = 0.0007) compared to nondrinkers. However, a faster increase in T2LV was observed in patients consuming 1-3 glasses of red wine per week compared to nondrinkers.
Higher total alcohol and red wine intake were associated with a lower cross-sectional level of neurologic disability in MS patients but increased T2LV accumulation. Further studies should explore a potential cause-effect neuroprotective relationship, as well as the underlying biological mechanisms. Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS). To assess the association between alcohol and red wine consumption and MS course. MS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study. Alcohol and red wine consumption were measured as servings/week. The primary outcome was the Expanded Disability Status Scale (EDSS) at the time of the questionnaire. Secondary clinical outcomes were the Multiple Sclerosis Severity Score (MSSS) and number of relapses in the year before the questionnaire. Secondary MRI outcomes included brain parenchymal fraction and T2 hyperintense lesion volume (T2LV). Appropriate regression models were used to test the association of alcohol and red wine intake on clinical and MRI outcomes. All analyses were controlled for sex, age, body mass index, disease phenotype (relapsing vs. progressive), the proportion of time on disease modifying therapy during the previous year, smoking exposure, and disease duration. In the models for the MRI outcomes, analyses were also adjusted for acquisition protocol. 923 patients (74% females, mean age 47 ± 11 years, mean disease duration 14 ± 9 years) were included in the analysis. Compared to abstainers, patients drinking more than 4 drinks per week had a higher likelihood of a lower EDSS score (OR, 0.41; p = 0.0001) and lower MSSS (mean difference, − 1.753; p = 0.002) at the time of the questionnaire. Similarly, patients drinking more than 3 glasses of red wine per week had greater odds of a lower EDSS (OR, 0.49; p = 0.0005) and lower MSSS (mean difference, − 0.705; p = 0.0007) compared to nondrinkers. However, a faster increase in T2LV was observed in patients consuming 1–3 glasses of red wine per week compared to nondrinkers. Higher total alcohol and red wine intake were associated with a lower cross-sectional level of neurologic disability in MS patients but increased T2LV accumulation. Further studies should explore a potential cause-effect neuroprotective relationship, as well as the underlying biological mechanisms. •Moderate alcohol consumption was associated with lower EDSS score and MSSS.•Drinking > 3 glasses of red wine/week was associated with lower EDSS score and MSSS.•Subjects drinking 1–3 glasses of red wine/week had an increase in MRI lesion volume accumulation. Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS).BACKGROUNDAlcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS).To assess the association between alcohol and red wine consumption and MS course.OBJECTIVETo assess the association between alcohol and red wine consumption and MS course.MS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study. Alcohol and red wine consumption were measured as servings/week. The primary outcome was the Expanded Disability Status Scale (EDSS) at the time of the questionnaire. Secondary clinical outcomes were the Multiple Sclerosis Severity Score (MSSS) and number of relapses in the year before the questionnaire. Secondary MRI outcomes included brain parenchymal fraction and T2 hyperintense lesion volume (T2LV). Appropriate regression models were used to test the association of alcohol and red wine intake on clinical and MRI outcomes. All analyses were controlled for sex, age, body mass index, disease phenotype (relapsing vs. progressive), the proportion of time on disease modifying therapy during the previous year, smoking exposure, and disease duration. In the models for the MRI outcomes, analyses were also adjusted for acquisition protocol.METHODSMS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study. Alcohol and red wine consumption were measured as servings/week. The primary outcome was the Expanded Disability Status Scale (EDSS) at the time of the questionnaire. Secondary clinical outcomes were the Multiple Sclerosis Severity Score (MSSS) and number of relapses in the year before the questionnaire. Secondary MRI outcomes included brain parenchymal fraction and T2 hyperintense lesion volume (T2LV). Appropriate regression models were used to test the association of alcohol and red wine intake on clinical and MRI outcomes. All analyses were controlled for sex, age, body mass index, disease phenotype (relapsing vs. progressive), the proportion of time on disease modifying therapy during the previous year, smoking exposure, and disease duration. In the models for the MRI outcomes, analyses were also adjusted for acquisition protocol.923 patients (74% females, mean age 47 ± 11 years, mean disease duration 14 ± 9 years) were included in the analysis. Compared to abstainers, patients drinking more than 4 drinks per week had a higher likelihood of a lower EDSS score (OR, 0.41; p = 0.0001) and lower MSSS (mean difference, - 1.753; p = 0.002) at the time of the questionnaire. Similarly, patients drinking more than 3 glasses of red wine per week had greater odds of a lower EDSS (OR, 0.49; p = 0.0005) and lower MSSS (mean difference, - 0.705; p = 0.0007) compared to nondrinkers. However, a faster increase in T2LV was observed in patients consuming 1-3 glasses of red wine per week compared to nondrinkers.RESULTS923 patients (74% females, mean age 47 ± 11 years, mean disease duration 14 ± 9 years) were included in the analysis. Compared to abstainers, patients drinking more than 4 drinks per week had a higher likelihood of a lower EDSS score (OR, 0.41; p = 0.0001) and lower MSSS (mean difference, - 1.753; p = 0.002) at the time of the questionnaire. Similarly, patients drinking more than 3 glasses of red wine per week had greater odds of a lower EDSS (OR, 0.49; p = 0.0005) and lower MSSS (mean difference, - 0.705; p = 0.0007) compared to nondrinkers. However, a faster increase in T2LV was observed in patients consuming 1-3 glasses of red wine per week compared to nondrinkers.Higher total alcohol and red wine intake were associated with a lower cross-sectional level of neurologic disability in MS patients but increased T2LV accumulation. Further studies should explore a potential cause-effect neuroprotective relationship, as well as the underlying biological mechanisms.CONCLUSIONSHigher total alcohol and red wine intake were associated with a lower cross-sectional level of neurologic disability in MS patients but increased T2LV accumulation. Further studies should explore a potential cause-effect neuroprotective relationship, as well as the underlying biological mechanisms. |
| Author | Glanz, Bonnie I. Guttmann, Charles R.G. Bakshi, Rohit Egorova, Svetlana Chitnis, Tanuja Weiner, Howard L. Healy, Brian C. Malik, Muhammad Taimur Diaz-Cruz, Camilo Kaplan, Tamara Chua, Alicia S. |
| Author_xml | – sequence: 1 givenname: Camilo surname: Diaz-Cruz fullname: Diaz-Cruz, Camilo organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 2 givenname: Alicia S. surname: Chua fullname: Chua, Alicia S. organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 3 givenname: Muhammad Taimur surname: Malik fullname: Malik, Muhammad Taimur organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 4 givenname: Tamara surname: Kaplan fullname: Kaplan, Tamara organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 5 givenname: Bonnie I. surname: Glanz fullname: Glanz, Bonnie I. organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 6 givenname: Svetlana surname: Egorova fullname: Egorova, Svetlana organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 7 givenname: Charles R.G. surname: Guttmann fullname: Guttmann, Charles R.G. organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 8 givenname: Rohit surname: Bakshi fullname: Bakshi, Rohit organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 9 givenname: Howard L. surname: Weiner fullname: Weiner, Howard L. organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 10 givenname: Brian C. surname: Healy fullname: Healy, Brian C. organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA – sequence: 11 givenname: Tanuja surname: Chitnis fullname: Chitnis, Tanuja email: tchitnis@partners.org organization: Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA |
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| Cites_doi | 10.1016/j.nicl.2015.06.009 10.1111/j.1530-0277.2006.00012.x 10.1055/s-0033-1343796 10.1177/1352458512448108 10.1191/1352458504ms1061oa 10.1002/eji.200425778 10.1007/s10067-008-1004-z 10.1001/jamaneurol.2014.1795 10.1530/EJE-12-0356 10.1016/j.autrev.2006.02.012 10.1097/BOR.0b013e32832a2e16 10.1017/S0029665112000171 10.1007/s13311-013-0214-5 10.1001/jama.296.23.2832 10.1136/jnnp-2011-301876 10.1002/jmri.1880020603 10.1001/jamaneurol.2013.5993 10.1177/1352458514527864 10.1016/j.annepidem.2007.01.005 10.1002/jmri.10053 10.1016/j.jneuroim.2011.12.007 10.1001/jamaneurol.2013.5858 10.1016/j.ejphar.2010.03.043 10.1038/nrd2060 10.1017/S0007114507838049 10.1016/B978-0-444-62619-6.00017-3 10.1111/j.1468-1331.2011.03596.x 10.1212/01.CON.0000450970.99322.84 10.1212/WNL.33.11.1444 10.1002/ana.22366 10.1017/S0029665110000121 10.1001/jamaneurol.2015.2742 10.1212/01.WNL.0000156155.19270.F8 |
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| Keywords | Alcohol Multiple sclerosis MSSS MRI EDSS |
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| References | Nova, E., Baccan, G.C., Veses, A., Zapatera, B., Marcos, A., 2012. Potential health benefits of moderate alcohol consumption: current perspectives in research. In: Proceedings of the Nutrition Society, England, pp. 307–315. Massa, O'Reilly, Munger, Ascherio (bib19) 2013; 19 Wei, Warfield, Zou, Wu, Li, Guimond, Mugler, Benson, Wolfson, Weiner, Guttmann (bib33) 2002; 15 Liao, Alfredsson, Karlson (bib16) 2009; 21 Mandrekar, Catalano, White, Szabo (bib18) 2006; 30 Wei, Guttmann, Warfield, Eliasziw, Mitchell (bib32) 2004; 10 NIAAA, National Institute on Alcohol Abuse and Alcoholism. What is a standard drink? Phillips, Fox (bib26) 2013; 33 Langley, Sauve (bib15) 2013; 10 Comalada, Camuesco, Sierra, Ballester, Xaus, Galvez, Zarzuelo (bib6) 2005; 35 Kurtzke (bib14) 1983; 33 Magrone, Jirillo (bib17) 2010; 69 Wang, Pan, Ye, Su, Li (bib31) 2008; 27 Bove, Musallam, Healy, Raghavan, Glanz, Bakshi, Weiner, De Jager, Miller, Chitnis (bib3) 2014 Noble, J.M., Weimer, L.H., 2014. Neurologic complications of alcoholism. Continuum (Minneapolis, Minn.) 20(3 Neurology of Systemic Disease), pp. 624–641. Fillmore, Stockwell, Chikritzhs, Bostrom, Kerr (bib8) 2007 Zahr, N.M., 2014. Structural and microstructral imaging of the brain in alcohol use disorders. In: Handbook of Clinical Neurology, vol. 125, pp. 275–290. (Accessed 8 January 2016). Soilu-Hanninen, Aivo, Lindstrom, Elovaara, Sumelahti, Farkkila, Tienari, Atula, Sarasoja, Herrala, Keskinarkaus, Kruger, Kallio, Rocca, Filippi (bib30) 2012; 83 Ascherio, Munger, White, Kochert, Simon, Polman, Freedman, Hartung, Miller, Montalban, Edan, Barkhof, Pleimes, Radu, Sandbrink, Kappos, Pohl (bib1) 2014; 71 Baur, Sinclair (bib2) 2006; 5 Gauthier, Glanz, Mandel, Weiner (bib11) 2006; 5 NIAAA, National Institute on Alcohol Abuse and Alcoholism. Recommended Alcohol Questions. Pakpoor, Goldacre, Disanto, Giovannoni, Goldacre (bib25) 2014; 71 Romeo, Warnberg, Nova, Diaz, Gomez-Martinez, Marcos (bib28) 2007; 98 Fitzgerald, Munger, Kochert, Arnason, Comi, Cook, Goodin, Filippi, Hartung, Jeffery, O'Connor, Suarez, Sandbrink, Kappos, Pohl, Ascherio (bib9) 2015; 72 D'Hooghe M, Haentjens, Nagels, De Keyser (bib7) 2012; 19 Carle, Pedersen, Knudsen, Perrild, Ovesen, Rasmussen, Jorgensen, Laurberg (bib4) 2012; 167 Hedstrom, Hillert, Olsson, Alfredsson (bib12) 2014; 71 Zhang, Liu, Shi (bib35) 2010; 636 Kikinis, Shenton, Gerig, Martin, Anderson, Metcalf, Guttmann, McCarley, Lorensen, Cline (bib13) 1992; 2 Foster, Zivadinov, Weinstock-Guttman, Tamano-Blanco, Badgett, Carl, Ramanathan (bib10) 2012; 243 Munger, Levin, Hollis, Howard, Ascherio (bib20) 2006; 296 Roxburgh, Seaman, Masterman, Hensiek, Sawcer, Vukusic, Achiti, Confavreux, Coustans, le Page, Edan, McDonnell, Hawkins, Trojano, Liguori, Cocco, Marrosu, Tesser, Leone, Weber, Zipp, Miterski, Epplen, Oturai, Sorensen, Celius, Lara, Montalban, Villoslada, Silva, Marta, Leite, Dubois, Rubio, Butzkueven, Kilpatrick, Mycko, Selmaj, Rio, Sa, Salemi, Savettieri, Hillert, Compston (bib29) 2005; 64 Chua, Egorova, Anderson, Polgar-Turcsanyi, Chitnis, Weiner, Guttmann, Bakshi, Healy (bib5) 2015; 8 Polman, Reingold, Banwell, Clanet, Cohen, Filippi, Fujihara, Havrdova, Hutchinson, Kappos, Lublin, Montalban, O'Connor, Sandberg-Wollheim, Thompson, Waubant, Weinshenker, Wolinsky (bib27) 2011; 69 Hedstrom (10.1016/j.msard.2017.06.011_bib12) 2014; 71 Wei (10.1016/j.msard.2017.06.011_bib33) 2002; 15 Magrone (10.1016/j.msard.2017.06.011_bib17) 2010; 69 Wei (10.1016/j.msard.2017.06.011_bib32) 2004; 10 Ascherio (10.1016/j.msard.2017.06.011_bib1) 2014; 71 Munger (10.1016/j.msard.2017.06.011_bib20) 2006; 296 D'Hooghe M (10.1016/j.msard.2017.06.011_bib7) 2012; 19 Comalada (10.1016/j.msard.2017.06.011_bib6) 2005; 35 10.1016/j.msard.2017.06.011_bib34 Mandrekar (10.1016/j.msard.2017.06.011_bib18) 2006; 30 Liao (10.1016/j.msard.2017.06.011_bib16) 2009; 21 Bove (10.1016/j.msard.2017.06.011_bib3) 2014 Polman (10.1016/j.msard.2017.06.011_bib27) 2011; 69 Baur (10.1016/j.msard.2017.06.011_bib2) 2006; 5 Kikinis (10.1016/j.msard.2017.06.011_bib13) 1992; 2 Langley (10.1016/j.msard.2017.06.011_bib15) 2013; 10 Romeo (10.1016/j.msard.2017.06.011_bib28) 2007; 98 Kurtzke (10.1016/j.msard.2017.06.011_bib14) 1983; 33 Wang (10.1016/j.msard.2017.06.011_bib31) 2008; 27 Massa (10.1016/j.msard.2017.06.011_bib19) 2013; 19 Zhang (10.1016/j.msard.2017.06.011_bib35) 2010; 636 10.1016/j.msard.2017.06.011_bib22 Pakpoor (10.1016/j.msard.2017.06.011_bib25) 2014; 71 10.1016/j.msard.2017.06.011_bib21 10.1016/j.msard.2017.06.011_bib24 10.1016/j.msard.2017.06.011_bib23 Carle (10.1016/j.msard.2017.06.011_bib4) 2012; 167 Phillips (10.1016/j.msard.2017.06.011_bib26) 2013; 33 Soilu-Hanninen (10.1016/j.msard.2017.06.011_bib30) 2012; 83 Foster (10.1016/j.msard.2017.06.011_bib10) 2012; 243 Fillmore (10.1016/j.msard.2017.06.011_bib8) 2007 Chua (10.1016/j.msard.2017.06.011_bib5) 2015; 8 Fitzgerald (10.1016/j.msard.2017.06.011_bib9) 2015; 72 Roxburgh (10.1016/j.msard.2017.06.011_bib29) 2005; 64 Gauthier (10.1016/j.msard.2017.06.011_bib11) 2006; 5 |
| References_xml | – volume: 33 start-page: 56 year: 2013 end-page: 65 ident: bib26 article-title: BG-12 in multiple sclerosis publication-title: Semin. Neurol. – volume: 2 start-page: 619 year: 1992 end-page: 629 ident: bib13 article-title: Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging publication-title: J. Magn. Reson. Imaging: JMRI – volume: 8 start-page: 606 year: 2015 end-page: 610 ident: bib5 article-title: Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models publication-title: NeuroImage Clin. – volume: 167 start-page: 483 year: 2012 end-page: 490 ident: bib4 article-title: Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case-control study publication-title: Eur. J. Endocrinol./Eur. Fed. Endocr. Soc. – volume: 98 start-page: S111 year: 2007 end-page: S115 ident: bib28 article-title: Moderate alcohol consumption and the immune system: a review publication-title: Br. J. Nutr. – reference: (Accessed 8 January 2016). – volume: 71 start-page: 1188 year: 2014 end-page: 1189 ident: bib25 article-title: Alcohol misuse disorders and multiple sclerosis risk publication-title: JAMA Neurol. – year: 2014 ident: bib3 article-title: Low testosterone is associated with disability in men with multiple sclerosis publication-title: Mult. Scler. – volume: 636 start-page: 1 year: 2010 end-page: 7 ident: bib35 article-title: Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation publication-title: Eur. J. Pharmacol. – volume: 35 start-page: 584 year: 2005 end-page: 592 ident: bib6 article-title: In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway publication-title: Eur. J. Immunol. – volume: 19 start-page: 53 year: 2013 end-page: 58 ident: bib19 article-title: Caffeine and alcohol intakes have no association with risk of multiple sclerosis publication-title: Mult. Scler. – volume: 10 start-page: 605 year: 2013 end-page: 620 ident: bib15 article-title: Sirtuin deacetylases as therapeutic targets in the nervous system publication-title: Neurother.: J. Am. Soc. Exp. NeuroTher. – volume: 5 start-page: 532 year: 2006 end-page: 536 ident: bib11 article-title: A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis climb study publication-title: Autoimmun. Rev. – volume: 5 start-page: 493 year: 2006 end-page: 506 ident: bib2 article-title: Therapeutic potential of resveratrol: the in vivo evidence publication-title: Nat. Rev. Drug Discov. – volume: 21 start-page: 279 year: 2009 end-page: 283 ident: bib16 article-title: Environmental influences on risk for rheumatoid arthritis publication-title: Curr. Opin. Rheumatol. – volume: 64 start-page: 1144 year: 2005 end-page: 1151 ident: bib29 article-title: Multiple sclerosis severity score: using disability and disease duration to rate disease severity publication-title: Neurology – reference: Zahr, N.M., 2014. Structural and microstructral imaging of the brain in alcohol use disorders. In: Handbook of Clinical Neurology, vol. 125, pp. 275–290. – volume: 71 start-page: 306 year: 2014 end-page: 314 ident: bib1 article-title: Vitamin D as an early predictor of multiple sclerosis activity and progression publication-title: JAMA Neurol. – start-page: S16 year: 2007 end-page: S23 ident: bib8 article-title: Moderate alcohol use and reduced mortality risk: systematic error in prospective studies and new hypotheses publication-title: Ann. epidemiol. – volume: 15 start-page: 203 year: 2002 end-page: 209 ident: bib33 article-title: Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy publication-title: J. Magn. Reson. Imaging: JMRI – volume: 296 start-page: 2832 year: 2006 end-page: 2838 ident: bib20 article-title: Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis publication-title: JAMA: J. Am. Med. Assoc. – volume: 69 start-page: 292 year: 2011 end-page: 302 ident: bib27 article-title: Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria publication-title: Ann. Neurol. – volume: 27 start-page: 1557 year: 2008 end-page: 1563 ident: bib31 article-title: Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis publication-title: Clin. Rheumatol. – volume: 33 start-page: 1444 year: 1983 end-page: 1452 ident: bib14 article-title: Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) publication-title: Neurology – reference: NIAAA, National Institute on Alcohol Abuse and Alcoholism. Recommended Alcohol Questions. – volume: 69 start-page: 279 year: 2010 end-page: 285 ident: bib17 article-title: Polyphenols from red wine are potent modulators of innate and adaptive immune responsiveness publication-title: Proc. Nutr. Soc. – reference: Noble, J.M., Weimer, L.H., 2014. Neurologic complications of alcoholism. Continuum (Minneapolis, Minn.) 20(3 Neurology of Systemic Disease), pp. 624–641. – volume: 83 start-page: 565 year: 2012 end-page: 571 ident: bib30 article-title: A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon beta-1b in patients with multiple sclerosis publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 10 start-page: 402 year: 2004 end-page: 406 ident: bib32 article-title: Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed? publication-title: Mult. Scler. – volume: 72 start-page: 1458 year: 2015 end-page: 1465 ident: bib9 article-title: Association of Vitamin D levels with multiple sclerosis activity and progression in patients receiving interferon Beta-1b publication-title: JAMA Neurol. – volume: 71 start-page: 300 year: 2014 end-page: 305 ident: bib12 article-title: Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk publication-title: JAMA Neurol. – reference: Nova, E., Baccan, G.C., Veses, A., Zapatera, B., Marcos, A., 2012. Potential health benefits of moderate alcohol consumption: current perspectives in research. In: Proceedings of the Nutrition Society, England, pp. 307–315. – volume: 243 start-page: 61 year: 2012 end-page: 68 ident: bib10 article-title: Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis publication-title: J. Neuroimmunol. – reference: NIAAA, National Institute on Alcohol Abuse and Alcoholism. What is a standard drink? – volume: 30 start-page: 135 year: 2006 end-page: 139 ident: bib18 article-title: Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10 publication-title: Alcohol. Clin. Exp. Res. – volume: 19 start-page: 616 year: 2012 end-page: 624 ident: bib7 article-title: Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis publication-title: Eur. J. Neurol. – volume: 8 start-page: 606 year: 2015 ident: 10.1016/j.msard.2017.06.011_bib5 article-title: Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models publication-title: NeuroImage Clin. doi: 10.1016/j.nicl.2015.06.009 – volume: 30 start-page: 135 issue: 1 year: 2006 ident: 10.1016/j.msard.2017.06.011_bib18 article-title: Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10 publication-title: Alcohol. Clin. Exp. Res. doi: 10.1111/j.1530-0277.2006.00012.x – volume: 33 start-page: 56 issue: 1 year: 2013 ident: 10.1016/j.msard.2017.06.011_bib26 article-title: BG-12 in multiple sclerosis publication-title: Semin. Neurol. doi: 10.1055/s-0033-1343796 – volume: 19 start-page: 53 issue: 1 year: 2013 ident: 10.1016/j.msard.2017.06.011_bib19 article-title: Caffeine and alcohol intakes have no association with risk of multiple sclerosis publication-title: Mult. Scler. doi: 10.1177/1352458512448108 – volume: 10 start-page: 402 issue: 4 year: 2004 ident: 10.1016/j.msard.2017.06.011_bib32 article-title: Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed? publication-title: Mult. Scler. doi: 10.1191/1352458504ms1061oa – volume: 35 start-page: 584 issue: 2 year: 2005 ident: 10.1016/j.msard.2017.06.011_bib6 article-title: In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway publication-title: Eur. J. Immunol. doi: 10.1002/eji.200425778 – volume: 27 start-page: 1557 issue: 12 year: 2008 ident: 10.1016/j.msard.2017.06.011_bib31 article-title: Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis publication-title: Clin. Rheumatol. doi: 10.1007/s10067-008-1004-z – volume: 71 start-page: 1188 issue: 9 year: 2014 ident: 10.1016/j.msard.2017.06.011_bib25 article-title: Alcohol misuse disorders and multiple sclerosis risk publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2014.1795 – volume: 167 start-page: 483 issue: 4 year: 2012 ident: 10.1016/j.msard.2017.06.011_bib4 article-title: Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case-control study publication-title: Eur. J. Endocrinol./Eur. Fed. Endocr. Soc. doi: 10.1530/EJE-12-0356 – volume: 5 start-page: 532 issue: 8 year: 2006 ident: 10.1016/j.msard.2017.06.011_bib11 article-title: A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis climb study publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2006.02.012 – volume: 21 start-page: 279 issue: 3 year: 2009 ident: 10.1016/j.msard.2017.06.011_bib16 article-title: Environmental influences on risk for rheumatoid arthritis publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0b013e32832a2e16 – ident: 10.1016/j.msard.2017.06.011_bib24 doi: 10.1017/S0029665112000171 – ident: 10.1016/j.msard.2017.06.011_bib21 – volume: 10 start-page: 605 issue: 4 year: 2013 ident: 10.1016/j.msard.2017.06.011_bib15 article-title: Sirtuin deacetylases as therapeutic targets in the nervous system publication-title: Neurother.: J. Am. Soc. Exp. NeuroTher. doi: 10.1007/s13311-013-0214-5 – volume: 296 start-page: 2832 issue: 23 year: 2006 ident: 10.1016/j.msard.2017.06.011_bib20 article-title: Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis publication-title: JAMA: J. Am. Med. Assoc. doi: 10.1001/jama.296.23.2832 – volume: 83 start-page: 565 issue: 5 year: 2012 ident: 10.1016/j.msard.2017.06.011_bib30 article-title: A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon beta-1b in patients with multiple sclerosis publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2011-301876 – volume: 2 start-page: 619 issue: 6 year: 1992 ident: 10.1016/j.msard.2017.06.011_bib13 article-title: Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging publication-title: J. Magn. Reson. Imaging: JMRI doi: 10.1002/jmri.1880020603 – volume: 71 start-page: 306 issue: 3 year: 2014 ident: 10.1016/j.msard.2017.06.011_bib1 article-title: Vitamin D as an early predictor of multiple sclerosis activity and progression publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.5993 – year: 2014 ident: 10.1016/j.msard.2017.06.011_bib3 article-title: Low testosterone is associated with disability in men with multiple sclerosis publication-title: Mult. Scler. doi: 10.1177/1352458514527864 – start-page: S16 year: 2007 ident: 10.1016/j.msard.2017.06.011_bib8 article-title: Moderate alcohol use and reduced mortality risk: systematic error in prospective studies and new hypotheses publication-title: Ann. epidemiol. doi: 10.1016/j.annepidem.2007.01.005 – volume: 15 start-page: 203 issue: 2 year: 2002 ident: 10.1016/j.msard.2017.06.011_bib33 article-title: Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy publication-title: J. Magn. Reson. Imaging: JMRI doi: 10.1002/jmri.10053 – volume: 243 start-page: 61 issue: 1–2 year: 2012 ident: 10.1016/j.msard.2017.06.011_bib10 article-title: Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2011.12.007 – volume: 71 start-page: 300 issue: 3 year: 2014 ident: 10.1016/j.msard.2017.06.011_bib12 article-title: Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.5858 – volume: 636 start-page: 1 issue: 1–3 year: 2010 ident: 10.1016/j.msard.2017.06.011_bib35 article-title: Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2010.03.043 – volume: 5 start-page: 493 issue: 6 year: 2006 ident: 10.1016/j.msard.2017.06.011_bib2 article-title: Therapeutic potential of resveratrol: the in vivo evidence publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd2060 – volume: 98 start-page: S111 issue: Suppl 1 year: 2007 ident: 10.1016/j.msard.2017.06.011_bib28 article-title: Moderate alcohol consumption and the immune system: a review publication-title: Br. J. Nutr. doi: 10.1017/S0007114507838049 – ident: 10.1016/j.msard.2017.06.011_bib34 doi: 10.1016/B978-0-444-62619-6.00017-3 – ident: 10.1016/j.msard.2017.06.011_bib22 – volume: 19 start-page: 616 issue: 4 year: 2012 ident: 10.1016/j.msard.2017.06.011_bib7 article-title: Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis publication-title: Eur. J. Neurol. doi: 10.1111/j.1468-1331.2011.03596.x – ident: 10.1016/j.msard.2017.06.011_bib23 doi: 10.1212/01.CON.0000450970.99322.84 – volume: 33 start-page: 1444 issue: 11 year: 1983 ident: 10.1016/j.msard.2017.06.011_bib14 article-title: Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) publication-title: Neurology doi: 10.1212/WNL.33.11.1444 – volume: 69 start-page: 292 issue: 2 year: 2011 ident: 10.1016/j.msard.2017.06.011_bib27 article-title: Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria publication-title: Ann. Neurol. doi: 10.1002/ana.22366 – volume: 69 start-page: 279 issue: 3 year: 2010 ident: 10.1016/j.msard.2017.06.011_bib17 article-title: Polyphenols from red wine are potent modulators of innate and adaptive immune responsiveness publication-title: Proc. Nutr. Soc. doi: 10.1017/S0029665110000121 – volume: 72 start-page: 1458 issue: 12 year: 2015 ident: 10.1016/j.msard.2017.06.011_bib9 article-title: Association of Vitamin D levels with multiple sclerosis activity and progression in patients receiving interferon Beta-1b publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2015.2742 – volume: 64 start-page: 1144 issue: 7 year: 2005 ident: 10.1016/j.msard.2017.06.011_bib29 article-title: Multiple sclerosis severity score: using disability and disease duration to rate disease severity publication-title: Neurology doi: 10.1212/01.WNL.0000156155.19270.F8 |
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| Title | The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis |
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