Hypersomnolence is associated with non-remission of major depressive disorder

This study aimed to investigate the prevalence, clinical correlates and the relationship between hypersomnolence and clinical outcomes in a cohort of MDD patients. This is a cross-sectional study of a MDD cohort in an university-affiliated adult psychiatric outpatient clinic. The diagnosis of MDD an...

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Veröffentlicht in:Sleep medicine Jg. 119; S. 35 - 43
Hauptverfasser: Cheung, Maxine Ming Sum, Lam, Siu Ping, Chau, Steven Wai Ho, Chan, Ngan Yin, Li, Tim MH, Wing, Yun Kwok, Chan, Joey W.Y.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.07.2024
Schlagworte:
Adult
Cross-Sectional Studies
Depression
Depressive Disorder, Major - epidemiology
Disorders of Excessive Somnolence - epidemiology
Excessive daytime sleepiness
Female
Humans
Hypersomnolence
Male
Middle Aged
Non-remission
Prevalence
Risk Factors
Suicidal Ideation
Surveys and Questionnaires
Excessive daytime sleepiness
Depression
Hypersomnolence
Non-remission
ISSN:1389-9457, 1878-5506, 1878-5506
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Zusammenfassung:This study aimed to investigate the prevalence, clinical correlates and the relationship between hypersomnolence and clinical outcomes in a cohort of MDD patients. This is a cross-sectional study of a MDD cohort in an university-affiliated adult psychiatric outpatient clinic. The diagnosis of MDD and severity of depression were ascertained by the clinician with structured clinical interviews. Each participant completed the Epworth Sleepiness Scale (ESS), 1-week sleep diary, and a battery of questionnaires that assessed usual sleep pattern, insomnia, anxiety, depression, fatigue and circadian preference. Hypersomnolence was defined as ESS score ≥14 among those reported ≥7 h of nighttime sleep. Univariate analysis and multiple logistic regression were used to analyze the relationships between the variables. Among 252 recruited subjects, 11 % met the criteria of hypersomnolence as defined by a ESS score ≥14 despite ≥7 h of nighttime sleep. Patients with hypersomnolence had greater depression ratings, higher rates of suicidal ideations over the past week, and more likely to meet a diagnosis of atypical depression (p < 0.05) than those without hypersomnolence. Step-wise logistic regression demonstrated that hypersomnolence was an independent risk factor associated with a 3-fold increase in the risk of depression non-remission (adjusted OR 3.13; 95 % CI 1.10–8.95; p = 0.034). Patients with hypersomnolence despite seemingly adequate sleep represent a subgroup of MDD patients who have a more severe illness profile with higher non-remission rate and suicidality. The findings highlight the importance of addressing both sleep and mood symptoms in the management of MDD. •EDS despite adequate sleep is a common problem in MDD (11 %).•Hypersomnolence is associated with a 3-fold increase in risk of non-remission.•Comprehensive assessment of hypersomnolence is needed to improve the depression outcomes.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1389-9457
1878-5506
1878-5506
DOI:10.1016/j.sleep.2024.04.018