PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

PrimPol is a DNA damage tolerant polymerase displaying both translesion synthesis (TLS) and (re)-priming properties. This led us to study the consequences of a PrimPol deficiency in tolerating mutagenic lesions induced by members of the APOBEC/AID family of cytosine deaminases. Interestingly, during...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 44; no. 10; pp. 4734 - 4744
Main Authors:	Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Pritchard, Colin, Blomberg, Olga S., Huijbers, Ivo J., van den Berk, Paul C.M., Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 02.06.2016
Subjects:	Animals B-Lymphocytes - enzymology Breast Neoplasms - enzymology Breast Neoplasms - genetics Cell Line Cell Survival - radiation effects Cells, Cultured CRISPR-Cas Systems Cytidine Deaminase - antagonists & inhibitors Cytidine Deaminase - metabolism DNA - metabolism DNA Primase - physiology DNA Replication DNA-Directed DNA Polymerase - physiology Female Genome Integrity, Repair and Humans Immunoglobulin Class Switching Mice, Inbred C57BL Minor Histocompatibility Antigens - metabolism Multifunctional Enzymes - physiology Mutagenesis Somatic Hypermutation, Immunoglobulin T-Lymphocytes - enzymology Ultraviolet Rays
ISSN:	0305-1048, 1362-4962
Online Access:	Get full text
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