The multiple sclerosis gut microbiota: A systematic review
•No major differences in the overall gut microbiota composition in MS cases vs. controls.•Abundance of six taxa differed in MS cases vs. controls, similarly observed across 2 ≥ studies.•Studies were generally too modest in size to adequately assess potential effect modifiers. To systematically revie...
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| Published in: | Multiple sclerosis and related disorders Vol. 37; p. 101427 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01.01.2020
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| ISSN: | 2211-0348, 2211-0356, 2211-0356 |
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| Abstract | •No major differences in the overall gut microbiota composition in MS cases vs. controls.•Abundance of six taxa differed in MS cases vs. controls, similarly observed across 2 ≥ studies.•Studies were generally too modest in size to adequately assess potential effect modifiers.
To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS.
We systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008–2018).
Of 415 articles identified ten fulfilled criteria. All studies used a case-control design, six sourced participants from the US, two Germany, one Italy, and one Japan. Nine focused exclusively on adults and one on children, totaling 286 MS and 296 control participants. Over 90% of cases had relapsing-remitting MS; disease duration ranged from 10.6 ± 6.5 months to 15.3 ± 8.6 years (mean±SD). Nine studies examined stool and one evaluated duodenal mucosa. Diverse platforms were used to quantify microbes: Illumina MiSeq, Roche 454, microarray, and fluorescence in situ hybridization. None of eight studies reported a significant alpha-diversity differences between cases and controls. Two of seven studies reported a difference in beta-diversity (P ≤ 0.002). At the taxa-level, ≥2 studies observed: lower relative abundance of Prevotella, Faecalibacterium prausnitzii, Bacteroides coprophilus, Bacteroides fragilis, and higher Methanobrevibacter and Akkermansia muciniphila in MS cases versus controls. Exposure to an immunomodulatory drug (IMD), relative to no exposure, was associated with individual taxonomic differences in three of three studies.
Gut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition. |
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| AbstractList | To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS.BACKGROUNDTo systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS.We systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008-2018).METHODSWe systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008-2018).Of 415 articles identified ten fulfilled criteria. All studies used a case-control design, six sourced participants from the US, two Germany, one Italy, and one Japan. Nine focused exclusively on adults and one on children, totaling 286 MS and 296 control participants. Over 90% of cases had relapsing-remitting MS; disease duration ranged from 10.6 ± 6.5 months to 15.3 ± 8.6 years (mean±SD). Nine studies examined stool and one evaluated duodenal mucosa. Diverse platforms were used to quantify microbes: Illumina MiSeq, Roche 454, microarray, and fluorescence in situ hybridization. None of eight studies reported a significant alpha-diversity differences between cases and controls. Two of seven studies reported a difference in beta-diversity (P ≤ 0.002). At the taxa-level, ≥2 studies observed: lower relative abundance of Prevotella, Faecalibacterium prausnitzii, Bacteroides coprophilus, Bacteroides fragilis, and higher Methanobrevibacter and Akkermansia muciniphila in MS cases versus controls. Exposure to an immunomodulatory drug (IMD), relative to no exposure, was associated with individual taxonomic differences in three of three studies.RESULTSOf 415 articles identified ten fulfilled criteria. All studies used a case-control design, six sourced participants from the US, two Germany, one Italy, and one Japan. Nine focused exclusively on adults and one on children, totaling 286 MS and 296 control participants. Over 90% of cases had relapsing-remitting MS; disease duration ranged from 10.6 ± 6.5 months to 15.3 ± 8.6 years (mean±SD). Nine studies examined stool and one evaluated duodenal mucosa. Diverse platforms were used to quantify microbes: Illumina MiSeq, Roche 454, microarray, and fluorescence in situ hybridization. None of eight studies reported a significant alpha-diversity differences between cases and controls. Two of seven studies reported a difference in beta-diversity (P ≤ 0.002). At the taxa-level, ≥2 studies observed: lower relative abundance of Prevotella, Faecalibacterium prausnitzii, Bacteroides coprophilus, Bacteroides fragilis, and higher Methanobrevibacter and Akkermansia muciniphila in MS cases versus controls. Exposure to an immunomodulatory drug (IMD), relative to no exposure, was associated with individual taxonomic differences in three of three studies.Gut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition.CONCLUSIONGut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition. •No major differences in the overall gut microbiota composition in MS cases vs. controls.•Abundance of six taxa differed in MS cases vs. controls, similarly observed across 2 ≥ studies.•Studies were generally too modest in size to adequately assess potential effect modifiers. To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS. We systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008–2018). Of 415 articles identified ten fulfilled criteria. All studies used a case-control design, six sourced participants from the US, two Germany, one Italy, and one Japan. Nine focused exclusively on adults and one on children, totaling 286 MS and 296 control participants. Over 90% of cases had relapsing-remitting MS; disease duration ranged from 10.6 ± 6.5 months to 15.3 ± 8.6 years (mean±SD). Nine studies examined stool and one evaluated duodenal mucosa. Diverse platforms were used to quantify microbes: Illumina MiSeq, Roche 454, microarray, and fluorescence in situ hybridization. None of eight studies reported a significant alpha-diversity differences between cases and controls. Two of seven studies reported a difference in beta-diversity (P ≤ 0.002). At the taxa-level, ≥2 studies observed: lower relative abundance of Prevotella, Faecalibacterium prausnitzii, Bacteroides coprophilus, Bacteroides fragilis, and higher Methanobrevibacter and Akkermansia muciniphila in MS cases versus controls. Exposure to an immunomodulatory drug (IMD), relative to no exposure, was associated with individual taxonomic differences in three of three studies. Gut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition. To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS. We systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008-2018). Of 415 articles identified ten fulfilled criteria. All studies used a case-control design, six sourced participants from the US, two Germany, one Italy, and one Japan. Nine focused exclusively on adults and one on children, totaling 286 MS and 296 control participants. Over 90% of cases had relapsing-remitting MS; disease duration ranged from 10.6 ± 6.5 months to 15.3 ± 8.6 years (mean±SD). Nine studies examined stool and one evaluated duodenal mucosa. Diverse platforms were used to quantify microbes: Illumina MiSeq, Roche 454, microarray, and fluorescence in situ hybridization. None of eight studies reported a significant alpha-diversity differences between cases and controls. Two of seven studies reported a difference in beta-diversity (P ≤ 0.002). At the taxa-level, ≥2 studies observed: lower relative abundance of Prevotella, Faecalibacterium prausnitzii, Bacteroides coprophilus, Bacteroides fragilis, and higher Methanobrevibacter and Akkermansia muciniphila in MS cases versus controls. Exposure to an immunomodulatory drug (IMD), relative to no exposure, was associated with individual taxonomic differences in three of three studies. Gut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition. |
| ArticleNumber | 101427 |
| Author | Waubant, Emmanuelle Mirza, Ali Zhu, Feng Graham, Morag Bernstein, Charles N. Forbes, Jessica D. Van Domselaar, Gary Tremlett, Helen |
| Author_xml | – sequence: 1 givenname: Ali orcidid: 0000-0002-9705-4624 surname: Mirza fullname: Mirza, Ali organization: Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada – sequence: 2 givenname: Jessica D. surname: Forbes fullname: Forbes, Jessica D. organization: Department of Internal Medicine, University of Manitoba, University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada – sequence: 3 givenname: Feng surname: Zhu fullname: Zhu, Feng organization: Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada – sequence: 4 givenname: Charles N. surname: Bernstein fullname: Bernstein, Charles N. organization: Department of Internal Medicine, University of Manitoba, University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada – sequence: 5 givenname: Gary surname: Van Domselaar fullname: Van Domselaar, Gary organization: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada – sequence: 6 givenname: Morag surname: Graham fullname: Graham, Morag organization: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada – sequence: 7 givenname: Emmanuelle orcidid: 0000-0001-5188-0157 surname: Waubant fullname: Waubant, Emmanuelle organization: University of California San Francisco, San Francisco, CA, United States – sequence: 8 givenname: Helen orcidid: 0000-0001-5804-2535 surname: Tremlett fullname: Tremlett, Helen email: helen.tremlett@ubc.ca organization: Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32172998$$D View this record in MEDLINE/PubMed |
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| Snippet | •No major differences in the overall gut microbiota composition in MS cases vs. controls.•Abundance of six taxa differed in MS cases vs. controls, similarly... To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS. We... To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS.BACKGROUNDTo... |
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| SubjectTerms | Bacteria Gut Microbiome Microbiota Multiple sclerosis Systematic review |
| Title | The multiple sclerosis gut microbiota: A systematic review |
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