Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree

Cancers are composed of genetically distinct subpopulations of malignant cells. DNA-sequencing data can be used to determine the somatic point mutations specific to each population and build clone trees describing the evolutionary relationships between them. These clone trees can reveal critical poi...

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Veröffentlicht in:	Blood cancer discovery Jg. 3; H. 3; S. 208
Hauptverfasser:	Wintersinger, Jeff A, Dobson, Stephanie M, Kulman, Ethan, Stein, Lincoln D, Dick, John E, Morris, Quaid
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.05.2022
Schlagworte:	Algorithms DNA Evolution, Molecular Humans Neoplasms - diagnosis Sequence Analysis, DNA
ISSN:	2643-3249, 2643-3249
Online-Zugang:	Weitere Angaben
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