Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway

To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells w...

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Bibliographic Details
Published in:	Gynecologic oncology Vol. 153; no. 3; pp. 639 - 650
Main Authors:	Guo, Yi, Cui, Wei, Pei, Yuqing, Xu, Danfei
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2019
Subjects:	A83–01 Adult Animals Blood Platelets Cadherins - genetics Cadherins - metabolism Cell Line, Tumor Cell Movement - drug effects Coculture Techniques Epithelial to mesenchymal transition Epithelial-Mesenchymal Transition - genetics Female Fibronectins - genetics Gene Expression Healthy Volunteers Humans Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice Middle Aged Neoplasm Invasiveness Neoplasm Transplantation Ovarian cancer Ovarian Neoplasms - blood Ovarian Neoplasms - pathology Platelet Platelet Count Pyrazoles - pharmacology Receptor, Transforming Growth Factor-beta Type I - antagonists & inhibitors Signal Transduction Smad Proteins - metabolism Snail Family Transcription Factors - genetics TGF-β Thiosemicarbazones - pharmacology Transforming Growth Factor beta - blood Transforming Growth Factor beta - metabolism Up-Regulation Vimentin - genetics Epithelial to mesenchymal transition TGF-β Platelet A83–01 Ovarian cancer
ISSN:	0090-8258, 1095-6859, 1095-6859
Online Access:	Get full text
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