Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors

•VIPergic promotion of depressive-like behaviors is dependent on the microbiome.•VIPergic activation increases SFB and hippocampal Th17 cells.•VIPergic activation induces IL-17A-mediated increase of hippocampal microglia. Chronic stress often has deleterious effects leading to the development of psy...

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Veröffentlicht in:	Brain, behavior, and immunity Jg. 123; S. 739 - 751
Hauptverfasser:	Medina-Rodriguez, Eva M., Han, Dongmei, Zeltzer, Shanie E., Moraskie Alvarez-Tabío, Michael P., O’Connor, Gregory, Daunert, Sylvia, Beurel, Eléonore
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Inc 01.01.2025
Schlagworte:	Animals Behavior, Animal - physiology Brain-Gut Axis - physiology Depression Depression - immunology Depression - metabolism Gastrointestinal Microbiome - physiology Hippocampus - metabolism Interleukin-17 - metabolism Male Mice Mice, Inbred C57BL Microglia Microglia - immunology Microglia - metabolism Stress, Psychological - immunology Stress, Psychological - metabolism Th17 cell Th17 Cells - immunology Th17 Cells - metabolism Vasoactive Intestinal Peptide - metabolism VIP Depression Th17 cell VIP Microglia
ISSN:	0889-1591, 1090-2139, 1090-2139
Online-Zugang:	Volltext
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