Activin upregulation by NF-κB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer

Soluble growth factors and cytokines within the tumor microenvironment aid in the induction of the epithelial-to-mesenchymal transition (EMT). Although EMT promotes the development of cancer-initiating cells (CIC), cellular mechanisms by which cancer cells maintain mesenchymal phenotypes remain poor...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Cancer research (Chicago, Ill.) Ročník 75; číslo 2; s. 426
Hlavní autori:	Wamsley, J Jacob, Kumar, Manish, Allison, David F, Clift, Sheena H, Holzknecht, Caitlyn M, Szymura, Szymon J, Hoang, Stephen A, Xu, Xiaojiang, Moskaluk, Christopher A, Jones, David R, Bekiranov, Stefan, Mayo, Marty W
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.01.2015
Predmet:	Activins - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Epithelial-Mesenchymal Transition Humans Inhibin-beta Subunits - metabolism Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mesoderm - metabolism Mesoderm - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology NF-kappa B - metabolism RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Spheroids, Cellular Up-Regulation
ISSN:	1538-7445, 1538-7445
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!