A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells

A new disubstituted terpyridine ligand and the corresponding tri‐copper(II) complex have been prepared and characterised. The binding affinity and binding mode of this tri‐copper complex (as well as the previously reported mono‐ and di‐copper analogues) towards duplex DNA were determined by using UV...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 18; no. 47; pp. 15133 - 15141
Main Authors:	Suntharalingam, Kogularamanan, Hunt, Douglas J., Duarte, Alexandra A., White, Andrew J. P., Mann, David J., Vilar, Ramon
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 19.11.2012 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Subjects:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology cancer Cell Line, Tumor Cell Proliferation - drug effects Chemistry Chemistry, Multidisciplinary Copper Copper - chemistry Crystallography, X-Ray Cytotoxicity Deoxyribonucleic acid DNA DNA - chemistry DNA - drug effects DNA Cleavage Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Enzymes HEK293 Cells Humans Leukemia Models, Molecular Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology oxidative cleavage Physical Sciences Science & Technology Structure-Activity Relationship NUCLEASE ACTIVITY DISPLACEMENT ASSAY HISTONE H2AX DOUBLE-STRANDED DNA PLATINUM COMPLEXES PHASE-II TRIAL oxidative cleavage DNA copper DNA cleavage 1,10-PHENANTHROLINE COPPER cancer TRINUCLEAR COPPER COMPLEX G-QUADRUPLEX DNA METAL-COMPLEXES
ISSN:	0947-6539, 1521-3765, 1521-3765
Online Access:	Get full text
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