Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk

Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting. There is limited information in humans regarding safety of ondansetron exposure to nursing infants and no adequate study looking at ondansetron pharmacokinetics during lactation. We developed a generic physiologicall...

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Veröffentlicht in:	Clinical pharmacology and therapeutics Jg. 111; H. 5; S. 1111
Hauptverfasser:	Job, Kathleen M, Dallmann, André, Parry, Samuel, Saade, George, Haas, David M, Hughes, Brenna, Berens, Pamela, Chen, Jia-Yu, Fu, Christina, Humphrey, Kelsey, Hornik, Christoph, Balevic, Stephen, Zimmerman, Kanecia, Watt, Kevin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2022
Schlagworte:	Breast Feeding Female Humans Infant Lactation Milk, Human Ondansetron - adverse effects Postpartum Period
ISSN:	1532-6535, 1532-6535
Online-Zugang:	Weitere Angaben
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