Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk

Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting. There is limited information in humans regarding safety of ondansetron exposure to nursing infants and no adequate study looking at ondansetron pharmacokinetics during lactation. We developed a generic physiologicall...

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Bibliographic Details

Published in:	Clinical pharmacology and therapeutics Vol. 111; no. 5; p. 1111
Main Authors:	Job, Kathleen M, Dallmann, André, Parry, Samuel, Saade, George, Haas, David M, Hughes, Brenna, Berens, Pamela, Chen, Jia-Yu, Fu, Christina, Humphrey, Kelsey, Hornik, Christoph, Balevic, Stephen, Zimmerman, Kanecia, Watt, Kevin
Format:	Journal Article
Language:	English
Published:	United States 01.05.2022
Subjects:	Breast Feeding Female Humans Infant Lactation Milk, Human Ondansetron - adverse effects Postpartum Period
ISSN:	1532-6535, 1532-6535
Online Access:	Get more information
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