Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms

Central administration of angiotensin IV (Ang IV) analogues attenuates scopolamine-induced amnesia. Ang IV mediates its effects by binding to a high affinity, binding site, AT 4 receptor, that has recently been identified as insulin regulated aminopeptidase (IRAP). The purpose of this study was to e...

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Vydáno v:	Behavioural brain research Ročník 154; číslo 1; s. 239 - 243
Hlavní autoři:	Albiston, Anthony L, Pederson, Eric S, Burns, Peta, Purcell, Brett, Wright, John W, Harding, Joseph W, Mendelsohn, Frederick A, Weisinger, Richard S, Chai, Siew Yeen
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Shannon Elsevier B.V 23.09.2004 Elsevier Science
Témata:	Aminopeptidase Aminopeptidases - metabolism Analysis of Variance Angiotensin Animal Animals AT 4 receptor Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Cognition Cystinyl Aminopeptidase Fundamental and applied biological sciences. Psychology Hemoglobins - metabolism IRAP Learning Learning Disorders - chemically induced Learning Disorders - metabolism Learning Disorders - physiopathology Learning. Memory Male Maze Learning - physiology Neurotransmission and behavior Peptide Fragments - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Reaction Time - physiology Receptors, Angiotensin - metabolism Scopolamine Hydrobromide Spatial Behavior - physiology AT 4 receptor IRAP Cognition Aminopeptidase Angiotensin Hyoscine Rat Rodentia Central nervous system Angiotensin receptor Experimental study Encephalon Learning Vertebrata Mammalia Acquisition process Animal Information processing Avoidance
ISSN:	0166-4328, 1872-7549
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Shrnutí:	Central administration of angiotensin IV (Ang IV) analogues attenuates scopolamine-induced amnesia. Ang IV mediates its effects by binding to a high affinity, binding site, AT 4 receptor, that has recently been identified as insulin regulated aminopeptidase (IRAP). The purpose of this study was to examine the effect of the distinct AT 4 ligand, LVV-hemorphin-7 (LVV-H7), on scopolamine-induced learning deficits, one which involves fear-conditioning and the other spatial learning. Rats were pretreated with an intracerebroventricular (ICV) dose of scopolamine hydrobromide followed by treatment with 1 nmol LVV-H7 or artificial cerebrospinal fluid (aCSF). During the acquisition phase of the water maze task, daily ICV infusions of 1 nmol of LVV-H7 25 min after scopolamine treatment produced marked improvement in both the latency and distance swum in order to locate the submerged platform using visual cues compared to animals treated with scopolamine only. In addition, the same dose of LVV-H7 attenuated the learning deficit observed for scopolamine-treated animals in the passive avoidance task. These studies clearly demonstrate that LVV-H7, like Ang IV, is a pharmacologically active AT 4 ligand that attenuates the deleterious effects of scopolamine on learning performance in two different behavioral paradigms.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0166-4328 1872-7549
DOI:	10.1016/j.bbr.2004.02.012