The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding

The cytoplasmic tail of the influenza A virus M2 proton-selective ion channel has been shown to be important for virus replication. Previous analysis of M2 cytoplasmic tail truncation mutants demonstrated a defect in incorporation of viral RNA (vRNA) into virions, suggesting a role for M2 in the rec...

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Bibliographic Details

Published in:	Journal of virology Vol. 82; no. 20; p. 10059
Main Authors:	Chen, Benjamin J, Leser, George P, Jackson, David, Lamb, Robert A
Format:	Journal Article
Language:	English
Published:	United States 01.10.2008
Subjects:	Amino Acid Sequence Animals Cell Line Cell Membrane - metabolism Humans Influenza A virus - physiology Molecular Sequence Data Protein Structure, Tertiary RNA, Viral - genetics RNA, Viral - metabolism Sequence Alignment Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Virus Assembly Virus Replication
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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