Physical Limit to Concentration Sensing Amid Spurious Ligands

To adapt their behavior in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this binding activity may interfere with the sensing of the ligand of...

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Vydané v:Physical review letters Ročník 115; číslo 3; s. 038102
Hlavný autor: Mora, Thierry
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 17.07.2015
Predmet:
Binding
Cascades
Changing environments
Detection
Kinetics
Ligands
Mathematical analysis
Models, Biological
Receptors
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - metabolism
Substrate Specificity
ISSN:0031-9007, 1079-7114, 1079-7114
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Popis
Shrnutí:To adapt their behavior in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this binding activity may interfere with the sensing of the ligand of interest. Here, I derive analytically the physical limit to the accuracy of concentration sensing amid a large number of interfering ligands. A scaling transition is found when the mean bound time of correct ligands is twice that of incorrect ligands. I discuss how the physical bound can be approached by a cascade of receptor states generalizing kinetic proofreading schemes.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0031-9007
1079-7114
1079-7114
DOI:10.1103/PhysRevLett.115.038102